Mortality due to TB-COVID-19 coinfection in India

Kumar, Malay; Surendran, Deepu; Manu, M.; Rakesh, P S; Balakrishnan, Shibu

doi:10.5588/ijtld.20.0947

Cited by 21 publications

(23 citation statements)

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“…At the start of the study, we were concerned that COVID-19 restrictions would prevent patients from collecting anti-TB medications, compromise drug adherence and reduce the ability of TB programme staff from obtaining information about final treatment outcomes. TB patients with associated COVID-19 coinfection have an increased risk of mortality [32,33]. We were worried that undetected COVID-19 in our TB patients might increase TB deaths during treatment.…”

Section: Discussionmentioning

confidence: 97%

Assessing the Real-Time Impact of COVID-19 on TB and HIV Services: The Experience and Response from Selected Health Facilities in Nairobi, Kenya

Mbithi¹,

Thekkur

Chakaya

et al. 2021

TropicalMed

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There was concern that the COVID-19 pandemic would adversely affect TB and HIV programme services in Kenya. We set up real-time monthly surveillance of TB and HIV activities in 18 health facilities in Nairobi so that interventions could be implemented to counteract anticipated declining trends. Aggregate data were collected and reported monthly to programme heads during the COVID-19 period (March 2020–February 2021) using EpiCollect5 and compared with monthly data collected during the pre-COVID period (March 2019–February 2020). During the COVID-19 period, there was an overall decrease in people with presumptive pulmonary TB (31.2%), diagnosed and registered with TB (28.0%) and in those tested for HIV (50.5%). Interventions to improve TB case detection and HIV testing were implemented from August 2020 and were associated with improvements in all parameters during the second six months of the COVID-19 period. During the COVID-19 period, there were small increases in TB treatment success (65.0% to 67.0%) and referral of HIV-positive persons to antiretroviral therapy (91.2% to 92.9%): this was more apparent in the second six months after interventions were implemented. Programmatic interventions were associated with improved case detection and treatment outcomes during the COVID-19 period, suggesting that monthly real-time surveillance is useful during unprecedented events.

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Section: Discussionmentioning

confidence: 97%

Assessing the Real-Time Impact of COVID-19 on TB and HIV Services: The Experience and Response from Selected Health Facilities in Nairobi, Kenya

Mbithi¹,

Thekkur

Chakaya

et al. 2021

TropicalMed

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“…61 – 64 However, while there is little evidence as yet that previous SARS-CoV-2 infection or COVID-19 disease affect either progression to TB disease or TB treatment outcomes, 65 the possibility of post-COVID-19 lung damage and subsequent vulnerability to TB is a major concern. 12 , 58 , 66 A number of studies are underway to investigate this issue. 67 – 69…”

Section: Vulnerability To Tbmentioning

confidence: 99%

The impact of COVID-19 on TB: a review of the data

McQuaid¹,

Vassall

Cohen

et al. 2021

int j tuberc lung dis

190

130

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Early in the COVID-19 pandemic, models predicted hundreds of thousands of additional TB deaths as a result of health service disruption. To date, empirical evidence on the effects of COVID-19 on TB outcomes has been limited. Here we summarise the evidence available at a country level, identifying broad mechanisms by which COVID-19 may modify TB burden and mitigation efforts. From the data, it is clear that there have been substantial disruptions to TB health services and an increase in vulnerability to TB. Evidence for changes in Mycobacterium tuberculosis transmission is limited, and it remains unclear how the resources required and available for the TB response have changed. To advocate for additional funding to mitigate the impact of COVID-19 on the global TB burden, and to efficiently allocate resources for the TB response, requires a significant improvement in the TB data available.

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“…Preliminary study from India showed a 0.37-4 per cent prevalence of TB among COVID-19 patients, while 1.14 per cent of the TB patients screened for COVID-19 were diagnosed with the disease, until October 2020 (out of the 266,365 TB patients screened, 3025 were COVID-19 positive), following the policy of dual screening of TB and COVID-19 by the Central TB Division of India (personal communication). A recent report from Kerala revealed that of the 177 cases of dual co-infection of active TB and COVID-19, 27 (15.2%) patients died though many of them had associated comorbidities other than TB 8 . COVID-19 pandemic has overtaken and impacted many other health delivery systems, even the well-performing public health programmes including the TB control programme 9 10 .…”

mentioning

confidence: 99%

COVID-19 & the National Tuberculosis Elimination Programme of India

Behera

2021

Indian J Med Res

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Mortality due to TB-COVID-19 coinfection in India

Cited by 21 publications

References 0 publications

Assessing the Real-Time Impact of COVID-19 on TB and HIV Services: The Experience and Response from Selected Health Facilities in Nairobi, Kenya

Assessing the Real-Time Impact of COVID-19 on TB and HIV Services: The Experience and Response from Selected Health Facilities in Nairobi, Kenya

The impact of COVID-19 on TB: a review of the data

COVID-19 & the National Tuberculosis Elimination Programme of India

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