Mortality and Life‐table in Down's Syndrome

Øster, Jakob; Nielsen, Ann

doi:10.1111/j.1651-2227.1975.tb03842.x

Cited by 136 publications

(61 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies reported that persons with DS had a mortality of 5-11 times that of the general population, 9,11,20,21 and our estimates support this. Many previous studies lacked information on mortality early in life, as our study does for those born before 1968.…”

Section: Discussionsupporting

confidence: 81%

“…Persons with mosaic DS would be expected to have a lower mortality than those with other DS karyotypes, because these people tend to have milder phenotypic manifestations, 6 and our data support this and are consistent with the findings in a previous study. 14 Most previous studies, 9,13,20,[23][24][25][26] although not all, 27 observed no statistically significant differences in mortality between males and females with DS. We found a 6% higher mortality in males but with confidence intervals that included no difference.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Survival among people with Down syndrome: a nationwide population-based study in Denmark

Zhu

Hasle

Correa

et al. 2013

Genetics in Medicine

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 96%

Survival among people with Down syndrome: a nationwide population-based study in Denmark

Zhu

Hasle

Correa

et al. 2013

Genetics in Medicine

View full text Add to dashboard Cite

“…This defect in MP chemotaxis in patients with DS may contribute not only to their increased susceptibility to infections, particularly of the respiratory tract (22,28), but may explain other immunologic abnormalities as well. The MP plays a n important role in both the afferent and the efferent pathways of the immune response (5).…”

Section: Discussionmentioning

confidence: 99%

“…Increased susceptibility to infection in patients with DS (22,28) may reflect several abnormalities in host defense mechanisms involving humoral and cellular immune responses (2,17) and the inflammatory-phagocytic process (13,15,27). No defect can be singled out as the most important one, hence the definition of the immunodeficiency of DS as a complex sum of several immunologic faults of variable intensity that can change with age (4).…”

mentioning

confidence: 99%

Defective Monocyte Chemotaxis in Children with Down's Syndrome

Nungaray

López-Osuna

et al. 1983

Pediatr Res

View full text Add to dashboard Cite

SummaryUnder-agarose random migration, chemokinesis and chemotaxis of monocytes from 36 patients with Down's syndrome were compared to those of monocytes from 42 healthy, age-matched control children. Random migration of monocytes from patients with Down's syndrome was comparable to that of controls. In contrast, chemotaxis of monocytes from patients with Down's syndrome was significantly decreased (P < 0.001) when com~ared to that of controis, even though chemokinesis was significantly increased (P < 0.001). Age, sex, and physical development of patients with Down's syndrome or of control children included in this study had no apparent effect upon monocyte mobility. Abbreviations CS, control serum DS, Down's syndrome MP, mononuclear phagocytes ZAS, zymosan-activated serum Increased susceptibility to infection in patients with DS (22,28) may reflect several abnormalities in host defense mechanisms involving humoral and cellular immune responses (2, 17) and the inflammatory-phagocytic process (13,15,27). No defect can be singled out as the most important one, hence the definition of the immunodeficiency of DS as a complex sum of several immunologic faults of variable intensity that can change with age (4). Cellmediated immunity in DS is predominantly impaired at its effector site (34): depressed in vitro lymphocyte responses, anergy or weak delayed type hypersensitivity skin reactions and decrease in circulating T cells have been reported in patients with DS (16,17), although lymphocytosis with high counts of T and B cells may be found in older, institutionalized patients (34).MP and lymphocytes constitute the bulk of the inflammatory cells in delayed hypersensitivity reactions, MP playing a crucial role in phagocytosis as well (5). Accumulation of mononuclear cells at such inflammatory sites depends largely on their response to chemotactic signals. Poor mobilization of these cells may contribute to the weakness of delayed hypersensitivity and other inflammatory reactions in DS (6). We measured random migration, chemokinesis (enhancement of random migration) and chemotaxis (directional migration) of MP from patients with DS and compared them to those of healthy age-matched children. We employed the agarose-plate method (21), which is less expensive, simpler, and more reproducible than the Boyden chamber method, even though the relative sensitivity of the two assays is still somewhat controversial (14,19). Only MP of a mononuclear leukocytes population seem to contribute to the migration pattern using the agarose device (21). MATERIALS AND METHODSPatients and controls. Thirty-six home-cared patients with DS (Trisomy 21: 14 females, 22 males, 6 months to 7 years of age) were studied. None of the patients had leukemia, suffered of overt infection or took any medication within 2 wk of the study. Fortytwo healthy children (15 females, 27 males, 6 months to 7 years of age) undergoing elective orthopaedic surgery, and matched as closely as possible with the patients for similar age and sex were used as controls. Differe...

show abstract

“…Na SD há evidências de casos de hipoplasia pulmonar, hipertensão pulmonar primária ou secundária, hipoplasia do maciço facial (FISCHER-BRANDIES, 1988) e comprometimentos imunitários caracterizando a maior vulnerabilidade a infecções politópicas (SIEGEL, 1948;LEVIN et al, 1975;OSTER et al, 1975;EPSTEIN et al, 1980;NURMI et al, 1982;LEVIN, 1987;AVANZINI et al, 1988;LOCKITCH et al, 1989;COOLEY & GRAHANA, 1991).…”

Section: 5-aspectos Específicos Na Conduta Da Síndrome De Downunclassified

Curvas padrão pôndero-estatural de portadores de Síndrome de Down procedentes da região urbana da cidade de São Paulo

Mustacchi¹

View full text Add to dashboard Cite

Mortality and Life‐table in Down's Syndrome

Cited by 136 publications

References 6 publications

Survival among people with Down syndrome: a nationwide population-based study in Denmark

Survival among people with Down syndrome: a nationwide population-based study in Denmark

Defective Monocyte Chemotaxis in Children with Down's Syndrome

Curvas padrão pôndero-estatural de portadores de Síndrome de Down procedentes da região urbana da cidade de São Paulo

Contact Info

Product

Resources

About