Morphosis, occult forces and ectoplasm-the role of glues and proteolysis in skin disease

Ryan, Terence J.

doi:10.1111/j.1365-2230.1985.tb00618.x

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…[46] This additional factor, the release of PAI-1 needs to be examined when plotting changing morphological relationships, cell shape changes, attachment grip and stick, or release from attachment. These underlie the interpretation of “activity.”[3147]…”

Section: Symmetrymentioning

confidence: 99%

Human pigmentation: A side effect adapted from a primitive organism′s survival, acting through cell attachment with an affinity for the keratinocyte and for elastin: Part I

Arianayagam

Ryan

2014

Indian Dermatol Online J

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Pigmentation featured millions of years ago and perhaps began with an amoeba frightening off a predator with some agent such as dopamine to prevent its attachment for phagocytosis by an enemy. This paper suggests that the environmental forces of grip and stick deserve greater emphasis and that mechanical forces involved in grip and stick or release from attachment, all point to control of proteases underlying pigmentation. There is an affinity for elastin as a pathway for melanin to exit its peripheral location in the epidermis into lymphatics and play a humeral role in defense mechanisms. The hair follicle follows the epidermal-dermal pattern of behavior with an affinity for elastin, a controlling function of melanin and through the bulge, an influence of mechanical forces and control by protease inhibitors.

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Section: Symmetrymentioning

confidence: 99%

Human pigmentation: A side effect adapted from a primitive organism′s survival, acting through cell attachment with an affinity for the keratinocyte and for elastin: Part I

Arianayagam

Ryan

2014

Indian Dermatol Online J

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Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers

Stacey

Burnand

Mahmoud-Alexandroni

et al. 1993

Journal of British Surgery

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Urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA) were assayed in biopsies from the base, edge and adjacent skin of ischaemic and venous ulcers using a functional bioimmunoassay and a standard immunoassay. Two series of 14 biopsies were examined: from seven venous and seven ischaemic ulcers in the first series, eight venous and six ischaemic in the second. It was found that tPA was detected in only four samples of ulcer edge using the bioimmunoassay and in no sample by the standard immunoassay. By contrast, uPA was detected in all but one ulcer edge biopsy and at a significantly lower median concentration in the adjacent skin (16.9 units/g) than the ulcer edge (26.1 units/g) or base (32.3 units/g) (both P < 0.01). Levels of uPA were greater in the edge and base of venous compared with ischaemic ulcers. The predominant plasminogen activator in chronic leg ulcers is uPA; this activator may play an important role in wound healing.

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Types of Chronic Wounds: Indications for Enzymatic Débridement

Sinclair

Ryan

1994

Proteolytic Enzymes and Wound Healing

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Morphosis, occult forces and ectoplasm-the role of glues and proteolysis in skin disease

Cited by 5 publications

References 26 publications

Human pigmentation: A side effect adapted from a primitive organism′s survival, acting through cell attachment with an affinity for the keratinocyte and for elastin: Part I

Human pigmentation: A side effect adapted from a primitive organism′s survival, acting through cell attachment with an affinity for the keratinocyte and for elastin: Part I

Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers

Types of Chronic Wounds: Indications for Enzymatic Débridement

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