Human pigmentation: A side effect adapted from a primitive organism′s survival, acting through cell attachment with an affinity for the keratinocyte and for elastin: Part I
Abstract:Pigmentation featured millions of years ago and perhaps began with an amoeba frightening off a predator with some agent such as dopamine to prevent its attachment for phagocytosis by an enemy. This paper suggests that the environmental forces of grip and stick deserve greater emphasis and that mechanical forces involved in grip and stick or release from attachment, all point to control of proteases underlying pigmentation. There is an affinity for elastin as a pathway for melanin to exit its peripheral locatio… Show more
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