Types of Chronic Wounds: Indications for Enzymatic Débridement

Sinclair, R. D.; Ryan, Terence J.

doi:10.1007/978-3-642-78891-8_2

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…Normal wound healing involves a number of overlapping processes: coagulation, inflammation, clot digestion, wound contraction, fibroplasia, matrix formation, angiogenesis, remodeling, and epithelialization. In the early stages of wound healing, autolytic debridement occurs through the action of neutrophil‐derived enzymes, including elastase, collagenase, myeloperoxidase, acid hydrolase, and lysosome (24). A number of protease inhibitors are also released, so as to restrict protease action to the wound bed and minimize potential damage to viable skin at the wound edge (24).…”

Section: Methods Of Debridementmentioning

confidence: 99%

Debridement and wound bed preparation

Falabella

2006

Dermatol Ther

109

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Debridement can play a vital role in wound bed preparation and the removal of barriers that impair wound healing. In accordance with the TIME principles, debridement can help remove nonviable tissue, control inflammation or infection, decrease excess moisture, and stimulate a nonadvancing wound edge. There are many types of debridement, each with a set of advantages and disadvantages that must be clearly understood by the healthcare team. Failure to use the correct debridement method for a given type of wound may lead to further delays in healing, increase patient suffering, and unnecessarily increase the cost of care. This review article discusses the various methods of debridement, describes currently available debriding agents, evaluates the clinical data regarding their efficacy and safety, and describes strategies for the management of problematic nonhealing wounds.

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Section: Methods Of Debridementmentioning

confidence: 99%

Debridement and wound bed preparation

Falabella

2006

Dermatol Ther

109

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“…Für therapeutische Interventionen im Rahmen einer Förderung der Wundheilung werden proteolytische Enzyme eingesetzt, die Peptidbindungen hydrolysieren können [50]. Diese proteolytischen Enzyme werden in Exopeptidasen,die die terminalen Amino-oder Carboxy-Proteine hydrolysieren, und in Endopeptidasen, die Peptidbindungen innerhalb der Proteinmoleküle degradieren, unterteilt.…”

Section: Konditionierung Chronischer Wunden Mittels Proteolytischer Eunclassified

“…Diese proteolytischen Enzyme werden in Exopeptidasen,die die terminalen Amino-oder Carboxy-Proteine hydrolysieren, und in Endopeptidasen, die Peptidbindungen innerhalb der Proteinmoleküle degradieren, unterteilt. Bei den Endopeptidasen können weiterhin Serin-, Histidin-,Aspartan-und MetalloPeptidasen unterschieden werden [50]. Schließlich werden proteolytische Enzyme als direkt wirksame und indirekt wirksame Enzyme klassifiziert.…”

Section: Konditionierung Chronischer Wunden Mittels Proteolytischer Eunclassified

Konditionierung chronischer Wunden mittels proteolytischer Enzyme

Dissemond

Goos

2003

Der Hautarzt

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In the past few years, several different proteolytic enzymes have been shown to be effective in conditioning the chronic wound beds. The use of proteolytic enzymes in wound-bed preparation enables a selective painless debridement. Moreover multiple positive effects on formation of granulation tissue and re-epithelialization have been observed. Therefore, a faster overall healing of chronic wounds may result. Moreover, numerous positive effects on a rapid induction of granulation are discussed. The supporting data do not fulfill the criteria of evidence-based medicine. For most chronic wounds today, enzymatic debridement represents a first choice method especially for outpatients and perhaps in combination with surgical debridement.

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“…Algunos autores han atribuido al pH ligeramente ácido un efecto antibacteriano (26), al constatar la desaparición de bacterias consideradas como habituales en este tipo de lesiones. Además, la presencia y control del exudado en la herida determina la disminución del dolor, ya que la humidificación de las terminaciones nerviosas conlleva un alivio del dolor (8,10,(26)(27)(28)(29).…”

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“…La última capa de la estructura de los apósitos de Sureskin ® II, al ser semioclusiva, impide que los microorganismos puedan llegar al lecho de la herida, ejerce un efecto de prevención frente a la infección de la herida (27) y su eficiente tecnología dolor ni irritación de la piel perilesional.…”

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