Morphology of the vasa vasorum in coronary arteries of the porcine heart: A new insight

Patzelt, Matej; Kachlík, David; Stingl, J; Šach, J; Stibor, Radek; Benada, Oldřich; Kofroňová, Olga; Musil, Vladimír

doi:10.1016/j.aanat.2019.02.006

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…Thirteen porcine hearts were fixed “ in toto ” in 10% formalin for 10 days, after which tissue blocks (of average size 2 × 3 × 2 cm) were prepared from the middle parts of the upper, middle, and lower segments of the anterior interventricular region, covered by epicardium and containing the epicardial tissues, including the stems of AIB and AIV as well as the adjacent myocardium of the interventricular septum and the anterior walls of both the left and right ventricle. The ventral surface borders of the segments were determined by the course of the terminal parts of the three largest left ventricular veins (Figure 1) (for more details see Patzelt et al, 2019).…”

Section: Methodsmentioning

confidence: 99%

“…For our previous study on the vasa vasorum (Patzelt et al, 2019), in seven intact hearts solution of India ink diluted at a ratio of 1:1 with normal saline at 26 C was injected by hand pressure into the aortic ostium of the left coronary artery. After the entire circulatory bed had been filled with the dye, the hearts were fixed for 10 days in 10% formalin, after which they underwent histological examination, following the same procedure as the previous group.…”

Section: India Ink Preparations (Group 2)mentioning

confidence: 99%

“…This topic has been of interest to us in two previously conducted studies, one was oriented on the morphology of the vasa vasorum interna of the descending ramus of the left coronary artery (AIB) (Patzelt et al, 2019), and the other was devoted to the valves of the small coronary veins (Musil, Sach, Patzelt, Kachlik, & Stingl, 2019). In both studies, the histological specimens from the anterior interventricular region of the porcine hearts were analyzed using classical histological techniques as well as India ink injections.…”

Section: Introductionmentioning

confidence: 99%

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Vascular supply of the anterior interventricular epicardial nerves and ventricular Purkinje fibers in the porcine hearts

Stingl

Zach

Šach

et al. 2020

Journal of Morphology

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The aim of this study was to perform a pilot histological and quantitative analysis of the blood vessels accompanying the epicardial nerves (vasa nervorum) in the porcine hearts. Twenty healthy porcine hearts were used in this study. The blood vessels were analyzed by light microscopy using four different staining techniques in transverse sections taken from the upper, middle, and lower segments of the anterior part of the interventricular region and the adjacent parts of the right and left ventricles containing epicardial nerves and the endocardial peripheral parts of the Purkinje fibers. In total, 317 epicardial nerves were detected. The vasa nervorum were present in 75.7% of these nerves. The vasa nervorum resembled arterioles and postcapillary and collecting venules. One hundred and forty nine epicardial nerves were perivascular, located in the adventitia of the anterior interventricular artery and vein. The remaining 168 nerves ran freely through the epicardial interstitium. The presence of the vasa nervorum was not related to topographical location or nerve diameter. Additionally, from a total of 33 analyzed ventricular complexes of Purkinje fibers small blood vessels located in their proximity were identified in only two cases. It can be concluded that the majority of the anterior epicardial nerves of porcine heart possess well-developed vasa nervorum. In contrast, similar blood vessels are rarely present in the vicinity of the Purkinje fibers. The data obtained contribute to a better understanding of the nutrition of the cardiac nerves.

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Section: Methodsmentioning

confidence: 99%

Section: India Ink Preparations (Group 2)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vascular supply of the anterior interventricular epicardial nerves and ventricular Purkinje fibers in the porcine hearts

Stingl

Zach

Šach

et al. 2020

Journal of Morphology

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“…Potassium hydroxide is a very strong alkaline, with strong hygroscopic characteristics, and is perfectly soluble in water, which enables a relatively easy preparation of a working solution of the expected concentration. The usefulness of KOH solutions in corrosion has been proven in many scientific studies [11,22,25,28,37,43].…”

Section: Corrosion With Alkaline Solutionsmentioning

confidence: 99%

Maceration stage in corrosion cast specimen procedure in anatomy: a minireview

et al. 2022

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“…During recent years, we have studied the existence of the vasa vasorum in the anterior interventricular branch of the left coronary artery (AIB) in porcine hearts (Patzelt et al, ), and in explanted failed aortocoronary bypasses (Stingl et al, ). We used vascular injections and several classic histological techniques to investigate these vessels.…”

Section: Introductionmentioning

confidence: 99%

Valves of the small coronary veins in porcine hearts

Musil

Šach

Patzelt

et al. 2019

Journal of Morphology

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The aim of the study was to investigate the existence of valves in small peripheral coronary veins of porcine hearts. The study was performed on 20 porcine hearts using standard histological methods. The veins in the subepicardial and intramyocardial regions of the anterior and posterior parts of the interventricular septum and in the wall of the right atrium were studied.Valves were present in intramyocardial veins (diameter of 75-180 μm), in the veins located just beneath the external surface of the myocardium (diameter 120-170 μm) and in the terminal segments of the ventricular veins (diameter 250 μm) opening into the stems of the anterior interventricular vein and middle cardiac vein. Valves were also recorded in most veins of the subepicardial space. The described rich presence of valves in the small coronary veins may contribute to a better comprehension of their hemodynamic properties. These findings may also help to improve the understanding of the efficacy of retrograde application of medications, a novel technique in cardiology and cardiac surgery. K E Y W O R D S porcine heart, small coronary veins, valves, histological analysis

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Morphology of the vasa vasorum in coronary arteries of the porcine heart: A new insight

Cited by 12 publications

References 19 publications

Vascular supply of the anterior interventricular epicardial nerves and ventricular Purkinje fibers in the porcine hearts

Vascular supply of the anterior interventricular epicardial nerves and ventricular Purkinje fibers in the porcine hearts

Maceration stage in corrosion cast specimen procedure in anatomy: a minireview

Valves of the small coronary veins in porcine hearts

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