Morphology, Clinicopathologic Correlations, and Mechanisms in Heart Valve Health and Disease

Schoen, Frederick J.

doi:10.1007/s13239-016-0277-7

Cited by 23 publications

(34 citation statements)

References 88 publications

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“…5 Advances in the surgical approach of valve diseases include progress in tissue engineering and the use of new surgical materials, improvement of mechanical and biological valves, and decreased use of thrombolytic and immunosuppressive drugs. 6 In industrialized countries, the prevalence of chronic diseases, including degenerative valve disease has increased due to the aging of the population. By 2050, the number of people who require valve replacement may triple.…”

Section: Study Selectionmentioning

confidence: 99%

Using a 3D printer in cardiac valve surgery: a systematic review

Boll

Rodrigues²,

Rodrigues

et al. 2019

Rev. Assoc. Med. Bras.

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SUMMARY BACKGROUND: The use of the 3D printer in complex cardiac surgery planning. OBJECTIVES: To analyze the use and benefits of 3D printing in heart valve surgery through a systematic review of the literature. METHODS: This systematic review was reported following the Preferred Reporting Items for Systematic Review and registered in the Prospero (International Prospective Register of Systematic Reviews) database under the number CRD42017059034. We used the following databases: PubMed, EMBASE, Scopus, Web of Science and Lilacs. We included articles about the keywords “Heart Valves”, “Heart Valve Prosthesis Implantation”, “Heart Valve Prosthesis”, “Printing, Three-Dimensional”, and related entry terms. Two reviewers independently conducted data extraction and a third reviewer solved disagreements. All tables used for data extraction are available at a separate website. We used the Cochrane Collaboration tool to assess the risk of bias of the studies included. RESULTS: We identified 301 articles and 13 case reports and case series that met the inclusion criteria. Our studies included 34 patients aged from 3 months to 94 years. CONCLUSIONS: Up to the present time, there are no studies including a considerable number of patients. A 3D-printed model produced based on the patient enables the surgeon to plan the surgical procedure and choose the best material, size, format, and thickness to be used. This planning leads to reduced surgery time, exposure, and consequently, lower risk of infection.

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Section: Study Selectionmentioning

confidence: 99%

Using a 3D printer in cardiac valve surgery: a systematic review

Boll

Rodrigues²,

Rodrigues

et al. 2019

Rev. Assoc. Med. Bras.

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“…A plethora of approaches and techniques have been established on TEHV and that has been recently and extensively reviewed elsewhere ( 134 – 136 ). Unique valve mechanobiology features and implications in the development and design of TEHV has been nicely reviewed by Schoen ( 137 ). Furthermore, utilization of different cell sources may confer of additional properties to the valve substitute which may, or may not, be desirable in the VHD environment.…”

Section: Future Solutions From Regenerative Medicine and Tissue Enginmentioning

confidence: 99%

Cell Sources for Tissue Engineering Strategies to Treat Calcific Valve Disease

Jover

Fagnano

Angelini

et al. 2018

Front. Cardiovasc. Med.

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Cardiovascular calcification is an independent risk factor and an established predictor of adverse cardiovascular events. Despite concomitant factors leading to atherosclerosis and heart valve disease (VHD), the latter has been identified as an independent pathological entity. Calcific aortic valve stenosis is the most common form of VDH resulting of either congenital malformations or senile “degeneration.” About 2% of the population over 65 years is affected by aortic valve stenosis which represents a major cause of morbidity and mortality in the elderly. A multifactorial, complex and active heterotopic bone-like formation process, including extracellular matrix remodeling, osteogenesis and angiogenesis, drives heart valve “degeneration” and calcification, finally causing left ventricle outflow obstruction. Surgical heart valve replacement is the current therapeutic option for those patients diagnosed with severe VHD representing more than 20% of all cardiac surgeries nowadays. Tissue Engineering of Heart Valves (TEHV) is emerging as a valuable alternative for definitive treatment of VHD and promises to overcome either the chronic oral anticoagulation or the time-dependent deterioration and reintervention of current mechanical or biological prosthesis, respectively. Among the plethora of approaches and stablished techniques for TEHV, utilization of different cell sources may confer of additional properties, desirable and not, which need to be considered before moving from the bench to the bedside. This review aims to provide a critical appraisal of current knowledge about calcific VHD and to discuss the pros and cons of the main cell sources tested in studies addressing in vitro TEHV.

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“…Аналіз останніх досліджень і публікацій вказує на те, що кожному з конституційних типів властиві специфічні особливості функціонування нервової, гуморальної, серцево-судинної та імунної систем (Miculic, 2008;Kazakova et al, 2009;Koenig, et al, 2014;Schoen, 2016). Тому вивчення патогенетичних механізмів виникнення дисфункцій ВНС у підлітків різних соматотипів має прогностичне значення перебігу адаптаційних реакцій організму, що дозволить виявляти донозологічні стани та здійснювати ранню профілактику соматичних захворювань, що зумовлює актуальність дослідження (Denefil, 2013;Messina et al, 2013).…”

Section: вступunclassified

Pathogenic specifics of development of vegetative dysfunction in adolescents in relation to their morphological status

Skyba

2017

Regul. Mech. Biosyst.

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Exploring the mechanisms of vegetative regulation in children and adolescents of different somatotypes has a prognostic value in regard to the character of adaptive reactions of the organism, as it facilitates the identification of the risk factors of pathological processes and states of vegetative systems, which may cause chronic illness in adulthood. The author defines the pathogenic specifics of development of vegetative dysfunction in adolescents in relation to their morphological status. Cardiointervalography and anthropometric, mathematical and statistical methods of research were used. Based on the results of cardiointervalography, the structure of initial vegetative tonus was established, which was characterized by prevalence of eutonia (38.4 ± 4.9%). The specific weight with background eutonia of adolescent boys and girls tended to be higher among the representatives of the thoracic and muscular somatotypes, compared to adolescents of the alimentive and osseous somatotypes (Р < 0.001–0.05). The established specifics indicate that thoracic and muscular somatotypes ensure optimal adaptation of organisms to the environment. Sympathicotonia was measured among the majority of boys of extreme constitutional variants (alimentive and osseous somatotypes) (36.3% and 30.0% respectively), which demonstrates the activation of adaptive mechanisms in the abovementioned category of examined adolescents, while among girls this phenomenon was evident among the representatives of the osseous and thoracic somatotypes (38.5% and 30.8% respectively). We found that the majority of examined adolescents (53.4%) had a normal vegetative reactivity. Gender differences in the structure of vegetative reactivity of adolescents could well be explained by the higher number of girls of asympaticotonic type (19.2%) compared to boys (7.3%, Р < 0.05). Furthermore, we found that hypersympathicotonic and asympathicotonic types of vegetative reactivity were characteristic of the majority of representatives of the alimentive and osseous somatotypes irrespective of the gender, which indicates activation of functioning of the cardiovascular system, decreased adaptive capacity of the organism among the examined group. The research shows that the group at risk of developing functional deviations in vegetative systems is formed by the representatives of the alimentive and osseous somatotypes.

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Morphology, Clinicopathologic Correlations, and Mechanisms in Heart Valve Health and Disease

Cited by 23 publications

References 88 publications

Using a 3D printer in cardiac valve surgery: a systematic review

Using a 3D printer in cardiac valve surgery: a systematic review

Cell Sources for Tissue Engineering Strategies to Treat Calcific Valve Disease

Pathogenic specifics of development of vegetative dysfunction in adolescents in relation to their morphological status

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