Morphology and natural history of familial adenomatous polyposis-associated dysplastic fundic gland polyps

Abstract

This cohort of patients with FAP-associated dysplastic fundic gland polyps rarely developed high-grade dysplasia and gastric adenocarcinoma was absent.

Sporadic Fundic Gland Polyps With Low-Grade Dysplasia: A Large Case Series Evaluating Pathologic and Immunohistochemical Findings and Clinical Behavior

“…None of the cases progressed to high-grade dysplasia or adenocarcinoma. Similar results were shown in a recent study by Arnason et al, 16 with none of their 15 cases of sporadic FGPD progressing to a higher grade lesion. This supports the currently held view that sporadic FGPDs are indolent lesions with no malignant potential.…”

“…16,23,25,26 The ❚Image 2❚ H&E, Ki-67, p53, and b-catenin, immunohistochemical comparison between sporadic fundic gland polyp with low-grade dysplasia (FGPD), familial adenomatous polyposis (FAP)-associated FGPD, and sporadic fundic gland polyp (FGP) without dysplasia (×100). (40) ++ (15) - (0) FAP, familial adenomatous polyposis; FGP, fundic gland polyp; FGPD, fundic gland polyp with low-grade dysplasia; IHC, immunohistochemistry; ++, >10% surface staining.…”

“…5,[12][13][14][15][16] Although sporadic and syndromic FGPs are histologically and histochemically indistinguishable, [17][18][19] they differ with respect to their genetic and molecular backgrounds. Sporadic FGPs show a very high frequency of activating mutations in the β-catenin gene, 20,21 whereas syndromic FGPs occur through an inherited germline mutation in the APC gene (adenomatous polyposis coli) coupled with additional somatic mutations, leading to complete inactivation of both copies of the APC tumor suppressor gene.…”

The first European family with gastric adenocarcinoma and proximal polyposis of the stomach: case report and review of the literature

“…It needs to be documented that there is no evidence of familiar adenomatous polyposis (FAP), as fundic gland polyposis is present in more than 80% of FAP patients (7), and 50% of those harbor foveolar adenoma with low-grade dysplasia apical to the cyst. Nevertheless, malignant transformation of fundic gland polyps in patients with FAP is rare (8) and corresponds to rare presence of large deletions around promoter 1B of APC gene in some of FAP-affected individuals (3).…”

Pathology of Gastric Cancer

“…However, in contrast to the development colon adenocarcinoma from adenomatous polyps in FAP patients, the development of gastric carcinoma in fundic gland polyps is rare [48][49][50][51]. Interestingly, there is a higher risk of neoplastic transformation in the stomach of Asian FAP patients as compared to Western FAP patients [52,53].…”