Objectives: Fundic gland polyps (FGPs) occur in two clinicalFundic gland polyps (FGPs) are the most common type of gastric polyp. 1,2 They typically occur in the body and fundus of the stomach and are composed of cystically dilated oxyntic glands lined by attenuated chief, parietal, and mucous neck cells. The polyp surface is lined by gastric foveolar epithelium. FGPs occur in two different clinical settings, sporadic and syndromic (familial adenomatous polyposis, or FAP).Sporadic FGPs have been reported in 0.8% to 1.9% of patients who undergo upper endoscopy. 3,4 They are slightly more common in women than in men, and their occurrence has been associated with prolonged use of proton pump inhibitors (PPIs). 3,4 In sporadic FGPs, low-grade epithelial dysplasia has been described, but its prevalence is extremely rare (approximately 1%). 5 Syndromic FGPs arise in patients with FAP, have been reported in 12.5% to 84% of patients with FAP, occur in a younger age group, and equally affect men and women. 4,[6][7][8][9][10][11][12][13] Epithelial dysplasia is more common Upon completion of this activity you will be able to:• describe the features of sporadic fundic gland polyps with low-grade dysplasia in terms of the incidence of these polyps, patient characteristics, and pathologic and immunohistochemical findings.• compare and differentiate between fundic gland polyps with low-grade dysplasia in the sporadic and syndromic setting.The ASCP is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The ASCP designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit ™ per article. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This activity qualifies as an American Board of Pathology Maintenance of Certification Part II Self-Assessment Module.The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.Exam is located at www.ascp.org/ajcpcme.