Morphologie, Lokalisation und Verhalten der basalgek�rnten Zellen in der Schleimhaut von Magen und Duodenum des Menschen

Fresen, Otto; Holzki, Josef

doi:10.1007/bf00339436

Cited by 8 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known today that these cells are of various types [2, 7, I 1, 32] and that they secrete numerous peptides (see [10]), although it is not possible to indicate the function of each cell type and the origin of all the peptides, in addition to this endocrine activity, there can also be in certain cases an apical exotrine activity [4,6,13,16] and a paracrine activity suspected by Masson and Berger [23] and confirmed since [12,31 ]. The paracrine activity apparently occurs on the lateral sides or, after migration of secretory granules, at the tip of a thick digitiform process [I, 5, 17, 18] originating at the basal pole [3, 9,19,35].…”

Section: Introductionmentioning

confidence: 99%

Three‐dimensional analysis demonstrates the presence of exocrine cytoplasmic vela between endocrine cells and basal lamina in the stomach of mammals

Pradal¹,

Piloquet²,

Vo³

et al. 1991

Biology of the Cell

View full text Add to dashboard Cite

Three-dimensional analysis demonstrated the presence of cytoplasmic vela extending from exocrine cells into the space between endocrine cells and basal lamina in the gastrointestinal epithelium of the rabbit; these structures were also observed in various other mammals. The following techniques were used to determine the morphologic characteristics of these vela and to study their significance: preparation of semiserial thin sections, three-dimensional reconstruction in plexiglass and lanthanum staining of pericellular spaces. It was found that these fine vela, devoid of major differentiated cell-constituents, sometimes form a pseudocircular crown at the base of endocrine cells. If the zone of basal apposition of the plasma membrane is referred to as ZBA and the zones of lateral apposition as ZLA, the presence of this velum makes it possible to distinguish a zone of immediate apposition without interposition (ZIA) and a mediate zone of apposition with interposition (ZMA) within the ZBA. Exocrine cell processes can also penetrate within endocrine cells in invaginations, and the depth of these invaginations can be demonstrated by lanthanum staining. Adjacent to the membrane zones defined above, other cytoplasmic microdomains-M(ZLA) and M(ZBA), as well as M(ZIA) and M(ZMA) of different morphofunctional significance may also be envisaged.

show abstract