Morphological differences in Parkinson’s disease with and without rest tremor

Benninger, David; Thees, Sebastian; Kollias, Spyros; Bassetti, Claudio L.; Waldvogel, Daniel

doi:10.1007/s00415-009-0092-2

Cited by 105 publications

(79 citation statements)

References 66 publications

(86 reference statements)

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“…Also, AR presents a closer relationship between physical capacity components and disease impairments than TD. Based on the recent literature that TD presents lesions in brain areas other than the striato-thalamic-cortical pathway (Benninger et al, 2009;Helmich et al, 2012;Lewis et al, 2011) and that this group presents a higher performance in the tests described here, mainly with the disease advance, two hypothesis were developed to explain our results: i) the striato-thalamic-cortical pathway has a closer relation with the physical capacity components performance; ii) the ageing process develops faster in AR patients.…”

Section: Discussionmentioning

confidence: 80%

“…This result could be explained by the recent theories that TD forms lesions in structures other than the striato-thalamocortical pathway (Benninger et al, 2009;Helmich et al, 2012;Lewis et al, 2011). These studies had clearly showed that tremor is not dependent on dopamine uptake in the striatum (Helmich, Janssen, Oyen, Bloem, & Toni, 2011), rather it is more closely related to pallidal dopamine and to the serotonergic system (Helmich et al, 2011).…”

Section: Discussionmentioning

confidence: 88%

“…PD is characterized by its heterogeneity, and two main motor subtypes are distinguished (Benninger, Thees, Kollias, Bassetti, & Waldvogel, 2009;Eggers, Kahraman, Fink, Schmidt, & Timmermann, 2011; S. J. Lewis et al, 2005): akinetic-rigidity (AR) and tremor-dominant (TD) subtypes.…”

Section: Introductionmentioning

confidence: 99%

“…In some cases AR patients show no tremor during their entire lifetime (Helmich et al, 2012). It is accepted that both subgroups are distinguished by different morphological factors (Benninger et al, 2009): AR patients present disturbances in the striatum-thalamo-cortical pathway, while TD patients have deficits in the cerebellum-thalamo-cortical pathway (Benninger et al, 2009;Eggers et al, 2011;Lewis et al, 2011). Both these groups also present differences in non-motor symptoms: AR patients have more depression, anxiety, higher cognitive impairment, lower attention and present a faster rate of disease progression (Alves, Larsen, Emre, Wentzel-Larsen, & Aarsland, 2006;Burn et al, 2012;Jankovic & Kapadia, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Parkinson's disease severity and motor subtype influence physical capacity components

Pereira

Pelicioni

Gobbi

2013

Motriz: rev. educ. fis.

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The severity of Parkinson's disease (PD) and PD's motor subtypes influence the components of physical capacity. The aim of this study was to investigate the impact of both PD severity and motor subtype in the performance of these components. Thirty-six PD patients were assigned into four groups: Tremor (TD) initial and TD mild, akinetic-rigid (AR) initial, and AR mild. Patients' strength, balance, coordination, mobility and aerobic capacity were evaluated and groups were compared using a two-way ANOVA (severity and subtype as factors). AR presents a poorer performance than TD in almost all tests. Also this performance was worsened with the advance of the disease in AR, contrary to TD. We conclude that AR and TD subgroups are different about their performance on physical capacity components, moreover, this performance worsens with the advance of the disease of the AR group, but not for TD.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Parkinson's disease severity and motor subtype influence physical capacity components

Pereira

Pelicioni

Gobbi

2013

Motriz: rev. educ. fis.

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“…DBS of the thalamic ventral intermediate nucleus (VIM) (Benabid et al, 1991;Caparros-Lefebvre et al, 1993;Koller et al, 1997;Lenz et al, 1994;Limousin, Speelman, Gielen, Janssens, & study, 1999) has proven efficacious in treatment of refractory tremor and suggests a cerebellar or a cerebello-thalamic generator (Mure et al, 2011;Stein & Aziz, 1999) which may interact with the striato-thalamo-cortical circuit (Deuschl et al, 2000). Neurophysiology (Timmermann et al, 2003), functional (Antonini, Moeller, Dhawan, & Eidelberg, 1998;Deiber et al, 1993;Fukuda et al, 2004) and structural imaging (Benninger, Thees, Kollias, Bassetti, & Waldvogel, 2009;Kassubek, Juengling, Hellwig, Spreer, & Lucking, 2002) provide further evidence for an involvement of the cerebellum in the pathogenesis of rest tremor, but the nature of the functional disturbance remains yet to be determined. So far, no study has reported efficacy of rTMS or tDCS on tremor.…”

Section: Current Concepts Of Non-invasive Brain Stimulation In Parkinmentioning

confidence: 99%

Non-invasive brain stimulation for Parkinson’s disease: Current concepts and outlook 2015

Hallett

2015

NRE

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Abstract. BACKGROUND AND PURPOSE:In advanced Parkinson's disease (PD), the emergence of symptoms refractory to conventional therapy poses a therapeutic challenge. The success of deep brain stimulation (DBS) and advances in the understanding of the pathophysiology of PD have raised interest in non-invasive brain stimulation as an alternative therapeutic tool. The rationale for its use draws from the concept that reversing abnormalities in brain activity and physiology thought to cause the clinical deficits may restore normal functioning. Currently the best evidence in support of this concept comes from DBS, which improves motor deficits, and modulates brain activity and motor cortex physiology, though whether a causal interaction exists remains largely undetermined. CONCLUSION: Most trials of non-invasive brain stimulation in PD have applied repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex and cortical areas of the motor circuit. Published studies suggest a possible therapeutic potential of rTMS and transcranial direct current stimulation (tDCS), but clinical effects so far have been small and negligible regarding functional independence and quality of life. Approaches to potentiate the efficacy of rTMS, including increasing stimulation intensity and novel stimulation parameters, derive their rationale from studies of brain physiology. These novel parameters simulate normal firing patterns or act on the hypothesized role of oscillatory activity in the motor cortex and basal ganglia in motor control. There may also be diagnostic potential of TMS in characterizing individual traits for personalized medicine.

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