Morphological and Histological Study of White Rats (Rattus norvegicus) Kidney Following the Consumption of Sumatran Wild Mango Extract (Mangifera spp.)

Abstract

The development of medicine requires preclinical testing of experimental animals. One of the potential plants to be developed as a new medicinal source is Sumatran wild mangoes (Mangifera spp.) which are known to have immunomodulatory activity and higher antioxidant value than cultivated Mangifera. This study was aimed to test the sub-chronic toxicity of the extract of 6 wild mango species on white rats' kidney function. This study used 21 treatments and 3 replications, consisted of 3 control treatments (control 0, with distilled water, positive control (stimuno) and negative control (CMC-Na 1%), and 6 types of Mangifera spp. (Mangifera sp.2 (Hutan), M. sumatrana, M. foetida (var. Batu, Limus, and Manis), and M. laurina) with 3 different dosages. Observations were made macroscopically (morphology) and histology through the glomerulus image to see the percentage of damage. The percentage of glomerulus damage was analyzed by ANOVA and Duncan's test. Based on the results showed that the kidney morphology looked like a pea with brownish-red color and the capsule looked flat (healthy) after being treated. Histologically, the administration of wild mango extract did not cause damage to the rats' kidneys, which was indicated by the glomerulus which was still covered by the bowman capsule and the boundary between the pars visceral epithelium and pars parietal epithelium was clearly visible.

Antibacterial Activity of Extracts of Wild Mango (Mangifera spp.), Ruellia tuberosa L and Leucobryum sp. Causes of Gangrene in Patients with Diabetes Mellitus

“…Pengujian pada jenis M. foetida var. Batu memiliki aktivitas antivirus tertinggi (Fitmawati et al, 2019;Fitmawati et al, 2020a;Fitmawati et al, 2020b). Penelitian ini menggunakan dua jenis mangga liar, yaitu: M. sumatrana, dan M. foetida.…”

The potency of wild mango Mangifera magnifica as a new source of antidiabetic agents with concurrent antioxidant activity

“…Investigation of antioxidant profiles (gallic acid and quercetin) reported that M. magnifica had a high antioxidant activity with an inhibitory concentration of 50% (IC50) 2.40 ppm (Fitmawati et al 2020a). Further research after obtaining metabolite data is preclinical testing using test animals, including testing of M. magnifica leaves with the highest phagocytosis value as an immunostimulant agent (Fitmawati et al 2020b). Toxicity tests on rat kidneys and liver showed damage of less than 25% (Fitmawati et al 2018).…”