Background: New findings on the potential of wild mangoes from the island of Sumatra as a source of antioxidant helps their conservation effort as it introduces their useful compounds to the public. This study aims to analyze the antioxidant profile and quantification of gallic acid and quercetin content from leaves and bark of Sumatran wild mangoes. Exploration and analysis of phytochemical constituents from 11 Sumatran wild mangoes was performed. Methods: Antioxidant activity of wild mangoes was analysed with 1,1- diphenyl-2-picryl hydroxyl (DPPH), and determination of quercetin and gallic acid content was performed by high performance liquid chromatography (HPLC) method. Total flavonoid and phenolic analysis was also performed. Curve fitting analysis used a linear regression approach. Results: The highest level of antioxidant activity, phenolic compound and flavonoid compound was found in the leaves and bark of Mangifera sp1. (MBS), the bark of M. foetida 3 (var. batu) and leaves of M. torquenda, and the bark and leaves of M. sumatrana, respectively. The content of gallic acid in leaves ranged from 5.23-35.48 mg/g dry weight. Quercetin content of wild mangoes leaves ranged from 0.76 to 1.16 mg/g dry weight with the lowest value in M. foetida 2 (var. manis) and the highest in M. laurina. Conclusion: The results obtained are expected to be useful in supporting the development of drugs that have antidegenerative effects.
Background: New findings on the potential of wild mangoes from the island of Sumatra as a source of antioxidant helps their conservation effort as it introduces their useful compounds to the public. This study aims to analyze the antioxidant profile and quantification of gallic acid and quercetin content from leaves and bark of Sumatran wild mangoes. Exploration and analysis of phytochemical constituents from 11 Sumatran wild mangoes was performed. Methods: Antioxidant activity of wild mangoes was analysed with 1,1- diphenyl-2-picryl hydroxyl (DPPH), and determination of quercetin and gallic acid content was performed by high performance liquid chromatography (HPLC) method. Total flavonoid and phenolic analysis was also performed. Curve fitting analysis used a linear regression approach. Results: The highest level of antioxidant activity, phenolic compound and flavonoid compound was found in the leaves and bark of Mangifera sp1. (MBS), the bark of M. foetida3 (var. batu) and leaves of M. torquenda, and the bark and leaves of M. sumatrana, respectively. The content of gallic acid in leaves ranged from 5.2270-35.4763 mg/g dry weight. Quercetin content of wild mangoes leaves ranged from 0.76 to 1.47 mg/g dry weight with the lowest value in M. foetida2 (var. manis) and the highest in M. laurina. Conclusion: The results obtained are expected to be useful in supporting the development of antidegenerative drugs from natural ingredients that have potential as immunomodulatory agents.
The development of medicine requires preclinical testing of experimental animals. One of the potential plants to be developed as a new medicinal source is Sumatran wild mangoes (Mangifera spp.) which are known to have immunomodulatory activity and higher antioxidant value than cultivated Mangifera. This study was aimed to test the sub-chronic toxicity of the extract of 6 wild mango species on white rats' kidney function. This study used 21 treatments and 3 replications, consisted of 3 control treatments (control 0, with distilled water, positive control (stimuno) and negative control (CMC-Na 1%), and 6 types of Mangifera spp. (Mangifera sp.2 (Hutan), M. sumatrana, M. foetida (var. Batu, Limus, and Manis), and M. laurina) with 3 different dosages. Observations were made macroscopically (morphology) and histology through the glomerulus image to see the percentage of damage. The percentage of glomerulus damage was analyzed by ANOVA and Duncan's test. Based on the results showed that the kidney morphology looked like a pea with brownish-red color and the capsule looked flat (healthy) after being treated. Histologically, the administration of wild mango extract did not cause damage to the rats' kidneys, which was indicated by the glomerulus which was still covered by the bowman capsule and the boundary between the pars visceral epithelium and pars parietal epithelium was clearly visible.
The new discovery about the potential of Mangifera foetida L. as an antiviral will help conservation efforts in nature while maintaining and increasing its biodiversity value. This study aims to characterize the in vitro potential of three varieties of M. foetida L. against the dengue virus. Dengue virus is infected in Vero cells, viral replication was measured using the Viral ToxGlo Assay method. The selectivity ability of Mangifera foetida L. stem bark extract to inhibit the dengue virus was seen from the Selectivity Index (SI) value. The standard curve between the concentration of the compound (μg/mL) and % cell viability was analyzed by linear regression using Microsoft Excel 2010 software. The results showed that the selectivity index (SI) value of M. foetida L stem bark extract of Limus, Manis and Batu varieties were 7.58, 6.82 and 16.43, respectively. It was concluded that the extract of Macang stem bark of the Limus, Manis and Batu varieties had the potential to be used as an antiviral for dengue.
Macang (Mangifera foetida L.) has potential as an effect herbal medicinal plant with antioxidant content, namely mangiferin. The aim of this study is to prove empirically study that macang has an immunomodulatory effect through preclinical testing. This study use white mice (Rattus norvegicus) as experimental animals and Staphylococcus aureus as test bacteria. Rats were give leaf extracts of 3 varieties of orally for 7 days using 3 prescribe doses in ppm. On the 8 th day, each rats was induce by an intraperitoneal section with 0,5 ml of the bacterial suspension tested. Observation of peritoneal fluid through smear preparations includes 2 parameters, phagocytosis activity and capacity. The result showed that the immunomodulatory effects on batu varieties were effective at dose 2 (10 ppm = 0,01 mg/g), limus varieties and manis varieties were effective at dose 1 (1 ppm = 0,001 mg/g). According to this research, it was concluded that leaf extracts of three varieties macang could be used as immunomodulators. AbstrakMacang (Mangifera foetida L.) mempunyai potensi sebagai tumbuhan obat herbal dengan kandungan antioksidan yaitu mangiferin. Tujuan penelitian ini adalah membuktikan efek imunomodulator pada tiga varietas macang (batu, limus dan manis) melalui uji praklinik. Penelitian ini menggunakan tikus putih (Rattus norvegicus) sebagai hewan uji dan Staphylococcus aureus sebagai bakteri uji. Tikus diberi ekstrak daun tiga varietas macang secara oral selama tujuh hari menggunakan tiga serial dosis dalam satuan ppm. Pada hari ke-8, setiap tikus putih diinduksi bagian intraperitoneal dengan 0,5 ml suspensi bakteri uji. Pengamatan cairan peritoneal melalui preparat apusan meliputi 2 parameter yaitu aktivitas dan kapasitas fagositosis. Hasil penelitian menunjukkan bahwa efek imunomodulator pada varietas batu
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