Morphological and Biochemical Changes During Aging and Photoaging of the Skin of C57BL/6J Mice

Sayama, Ayako; Soushin, Tomomi; Okada, Taro; Doi, Kunio; Nakayama, Hiroyuki

doi:10.1293/tox.23.133

Cited by 23 publications

(14 citation statements)

References 25 publications

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“…Present theories of skin aging almost completely exclude the involvement of AT in this process. At the same time, significant modification of dWAT was observed both in intrinsically 51,76 and extrinsically 77,78 aged murine skin. Reduction in the dWAT in a chronically UV-irradiated skin was shown to correlate with replacement of this volume by fibrotic structures indicating the involvement of recently revealed effect of adipocyte-myofibroblast transition, 39 which mainly involves the dermal adipocytes.…”

Section: Facial Aging On Mesoscopic Scalementioning

confidence: 79%

The Facial Adipose Tissue: A Revision

Kruglikov¹,

Trujillo

Kristen

et al. 2016

Facial plast Surg

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Recent advantages in the anatomical understanding of the face have turned the focus toward the subcutaneous and deep facial fat compartments. During facial aging, these fat-filled compartments undergo substantial changes along with other structures in the face. Soft tissue filler and fat grafting are valid methods to fight the signs of facial aging, but little is known about their precise effect on the facial fat. This narrative review summarizes the current knowledge about the facial fat compartments in terms of anatomical location, histologic appearance, immune-histochemical characteristics, cellular interactions, and therapeutic options. Three different types of facial adipose tissue can be identified, which are located either superficially (dermal white adipose tissue) or deep (subcutaneous white adipose tissue): fibrous (perioral locations), structural (major parts of the midface), and deposit (buccal fat pad and deep temporal fat pad). These various fat types differ in the size of the adipocytes and the collagenous composition of their extracellular matrix and thus in their mechanical properties. Minimal invasive (e.g., soft tissue fillers or fat grafting) and surgical interventions aiming to restore the youthful face have to account for the different fat properties in various facial areas. However, little is known about the macro- and microscopic characteristics of the facial fat tissue in different compartments and future studies are needed to reveal new insights to better understand the process of aging and how to fight its signs best.

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Section: Facial Aging On Mesoscopic Scalementioning

confidence: 79%

The Facial Adipose Tissue: A Revision

Kruglikov¹,

Trujillo

Kristen

et al. 2016

Facial plast Surg

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“…Recently, it was shown that myofibroblasts producing fibrosis appear from adiponectin-positive intradermal progenitors. 69 , 70 Although AMT was first described after subcutaneous injections of bleomycin, 69 substitution of the sWAT by fibrosis was observed also after application of different physical factors including UV radiation 5 , 71 , 72 and thus can be effectively involved in the volume loss connected with aging processes. This trans-differentiation appears to be of general importance and should be involved in such processes as wound healing and reversible disappearance of mammary adipocytes during lactation.…”

Section: Introductionmentioning

confidence: 99%

Role of adipose tissue in facial aging

Wollina

Wetzker

Abdel-Naser

et al. 2017

CIA

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Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging.

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“…In [44], dWAT in C57BL/6J mice was shown to be significantly reduced after UVA irradiation (three times weekly, 8 weeks, 24 J/cm 2 per session). Similar results were obtained in [76] where the 6-week-old C57BL/6J female mice were exposed to a low-dose UVB radiation (four times weekly, 30 weeks, gradually increasing doses).…”

Section: Introductionmentioning

confidence: 99%

Skin aging: are adipocytes the next target?

Kruglikov¹,

Scherer

2016

Aging

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Dermal white adipose tissue (dWAT) is increasingly appreciated as a special fat depot. The adipocytes in this depot exert a variety of unique effects on their surrounding cells and can undergo massive phenotypic changes. Significant modulation of dWAT content can be observed both in intrinsically and extrinsically aged skin. Specifically, skin that has been chronically photo-damaged displays a reduction of the dWAT volume, caused by the replacement of adipocytes by fibrotic structures. This is likely to be caused by the recently uncovered process described as “adipocyte-myofibroblast transition” (AMT). In addition, contributions of dermal adipocytes to the skin aging processes are also indirectly supported by spatial correlations between the prevalence of hypertrophic scarring and the appearance of signs of skin aging in different ethnic groups. These observations could elevate dermal adipocytes to prime targets in strategies aimed at counteracting skin aging.

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Morphological and Biochemical Changes During Aging and Photoaging of the Skin of C57BL/6J Mice

Cited by 23 publications

References 25 publications

The Facial Adipose Tissue: A Revision

The Facial Adipose Tissue: A Revision

Role of adipose tissue in facial aging

Skin aging: are adipocytes the next target?

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