2016
DOI: 10.18632/aging.100999 View full text |Buy / Rent full text
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Abstract: Dermal white adipose tissue (dWAT) is increasingly appreciated as a special fat depot. The adipocytes in this depot exert a variety of unique effects on their surrounding cells and can undergo massive phenotypic changes. Significant modulation of dWAT content can be observed both in intrinsically and extrinsically aged skin. Specifically, skin that has been chronically photo-damaged displays a reduction of the dWAT volume, caused by the replacement of adipocytes by fibrotic structures. This is likely to be cau… Show more

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“…Recent work highlighted the importance of adipocytes in maintaining skin homeostasis, contributing to the regulation of hair cycle, wound healing, and immune function Rivera-Gonzalez et al, 2014). We assessed the age-related oscillations of dWAT in 2-, 6-, 11-, and 13month-old mice (Foster et al, 2018;Kruglikov and Scherer, 2016;Wang et al, 2013a). Consistent with previous reports in B6D2 females (Wang et al, 2013b), CO dWAT thickness increased at 6-and 11-months relative to 2-month and was significantly reduced at 13-month relative to 11-month ( Figure 4a).…”
Section: Middle-aged Mr Epidermal Knockout Skin Features Compartment-mentioning
“…In addition, soluble cytokines are produced in the upper epidermis upon UV exposure and diffuse into the sWAT, causing loss of PPARγ expression, as well as reduced free fatty acid and triglyceride content. In mice, chronic exposure to UVA causes transition of dermal adipocytes to myofibroblasts, leading to replacement of dWAT with fibrotic tissue and thereby promoting morphological and functional alterations in the skin [53]. Taken together, these processes induce loss of sWAT and concurrent accumulation of vWAT in the skin with age, promoting the typical appearance of aged skin.…”
Section: Impact Of Age-induced Macromolecular Damage On (Pre-)adipocymentioning
“…Following treatment with bleomycin, excessive skin scarring is accompanied by the loss of adipocytes and conversion of adipose progenitors into myofibroblasts 96 . In analogy with these observations, researchers have proposed that dWAT might contribute to skin fibrosis via the so-called adipocyte-to-myofibroblast transition mechanism during skin aging, including UV-induced aging 97 and male pattern baldness 98 .…”
Section: Defence Functions Of Dermal Fatmentioning
“…A reduction of dWAT has been described in chronically UV‐irradiated skin. As a result, adipocyte‐myofibroblast transition becomes favored which leads to the deposition of extracellular fibrotic material and skin wrinkling (Kruglikov & Scherer, ; Marangoni et al, ). The adipose tissue‐related aging is associated with local inflammation under the participation of macrophages and cytokines (Wollina, Goldman, & Tchernev, ; Wollina, Wetzker, Abdel‐Naser, & Kruglikov, ).…”
Section: Facial Adipose Tissuementioning
“…A reduction of dWAT has been described in chronically UV-irradiated skin. As a result, adipocyte-myofibroblast transition becomes favored which leads to the deposition of extracellular fibrotic material and skin wrinkling (Kruglikov & Scherer, 2016b;Marangoni et al, 2015). The…”
Section: Facial Adipose Tissuementioning