Morphological and autoradiographic investigation of the alterations of intestinal mucosa after a single injection of 1,2-dimethylhydrazine

Löhrs, U.; Wiebecke, B; Eder, M.

doi:10.1007/bf02052919

Cited by 17 publications

(2 citation statements)

References 10 publications

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“…In this work, only 2 animals of 20 developed extra-intestinal malignancies: one carcinoma of the external ear duct and one hepatic fibrosarcoma; in these 2 cases, intestinal adeno carcinomas were also found. Carcinoma and hemangio-endothelioma of the liver, carcinoma of the kidney, and adenocarcinoma of the ear duct have occasionally been reported after administration of DM I I in the rat, but al ways with a low incidence [3,7,10,16].…”

Section: Discussionmentioning

confidence: 99%

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An Experimental Model for Cancer of the Colon and Rectum

Martin

Michiels

et al. 1973

Digestion

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1,2-Dimethylhydrazine(DMH) was administered s.c. to a group of 20 inbred BD-IX rats at the dose of 15 mg/kg body weight, weekly for 7 months. Intestinal adenocarcinoma have been found in all of the treated animals, often associated with hyperplastic or dysplastic lesions. The intestinal cancers gave metastases in 14 animals. The low incidence of extra-intestinal malignancies, the relatively short induction time, the similarity to human colorectal adenocarcinoma, make the DMH-induced intestinal cancer a highly effective experimental model.

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Section: Discussionmentioning

confidence: 99%

“…[15] and Lours el al. [7] in mice. A personal attempt to induce colonic cancer in inbred mice (strain C3H) with DMH gave positive results but was dis rupted by an early high death rate explained by revelation of mouse pox virus by DMH.…”

Section: Discussionmentioning

confidence: 99%

An Experimental Model for Cancer of the Colon and Rectum

Martin

Michiels

et al. 1973

Digestion

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Colon carcinogens: Their metabolism and mode of action

Weisburger

1971

Cancer

209

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Colon cancer in man almost certainly is induced by environmental factors, probably consumed with food. Except for one breed of hamsters, colon cancer is infrequent in laboratory or domestic animals. Reliable induction of colon cancer can be achieved with 2 broad classes of chemicals: 1. derivatives of 3‐methyl‐4‐aminobiphenyl, and 2. derivatives of 1, 2‐dimethylhydrazine, including the plant product cycasin. Sometimes an unknown ingredient of bracken fern causes cecal or colonic cancers. The metabolism of 4‐aminobiphenyl derivatives involves, among other steps, N‐hydroxylation, conjugation of the metabolite with glucuronic acid, secretion of the conjugate in bile, liberation of the free N‐hydroxy compound, the postulated active intermediate, by action of bacterial flora in large intestine where reaction with significant tissue, cell, and molecular elements occurs. After oral intake of cycasin the aglycone methylazoxymethanol is likewise freed for reaction in colon by bacterial enzymes. 1,2‐Dimethylhydrazine yields azoxymethane which is hydroxylated in liver, conjugated with glucuronic acid and secreted in bile, again to be split in gut with liberation of the active methylazoxy‐methanol. On the basis of these models, colon cancer formation in man may involve: 1. ingestion of complex carcinogens with diet, with liberation of the active agent by bacterial enzymes; 2. ingestion of procarcinogens, absorption, metabolism by liver, secretion in bile, and freeing of active agent in gut; 3. production of active agent by bacterial flora in gut by conversion of select food precursors, and 4. production of a mycotoxin by an intestinal microorganism.

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Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma

Filipe¹,

Branfoot²

1974

Cancer

233

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Our previous studies have shown that histologically normal mucosa adjacent to carcinomas of the large intestine is often abnormal histochemically. This „transitional”︁ mucosa, as we termed it, is characterized by an increase of sialomucins, accompanied usually by a decrease or absence of the sulphomucins which are predominant in the normal mucosa of the large intestine. The extent and intensity of these mucin changes were not clear, and so we have mapped them by cutting strips of mucosa from the whole length of 25 surgical specimens. This work confirms that the pattern of mucus secretion is altered around carcinomas, but also shows similar changes in patches of mucosa at a distance from frank tumors. The increase in sialomucins is directly related to the extent of invasion by a carcinoma according to Dukes' classification, but not to its degree of differentiation or to its histologic pattern. It is suggested that the mucin changes may reflect a transformation to a fetal type of epithelium and indicate an early stage in carcinogenesis. The practical value of these findings in diagnosis and prognosis is discussed.

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Morphological and autoradiographic investigation of the alterations of intestinal mucosa after a single injection of 1,2-dimethylhydrazine

Cited by 17 publications

References 10 publications

An Experimental Model for Cancer of the Colon and Rectum

An Experimental Model for Cancer of the Colon and Rectum

Colon carcinogens: Their metabolism and mode of action

Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma

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