An Experimental Model for Cancer of the Colon and Rectum

Martin, Monique; Martin, François; Michiels, R; Bastien, H; Justrabo, E; Bordes, M.; B, Viry

doi:10.1159/000197298

Cited by 76 publications

(18 citation statements)

References 5 publications

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“…squamous-cell carcinomas of the ear canal). The incidence of earcanal tumours was less than 10% in other reports commenting on this phenomenon (Nigro et al, 1973;Martin et al, 1973) and only animals treated with DMH plus C. parrurn have yet presented with such a lesion. This could be interpreted as evidence for C. parvum-induced depression of immunosurveillance.…”

mentioning

confidence: 79%

Corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats

Cruse¹,

Lewin²,

Clark³

1978

Br J Cancer

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mentioning

confidence: 79%

Corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats

Cruse¹,

Lewin²,

Clark³

1978

Br J Cancer

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“…Two serially graftable tumour lines, DHB and DHD were obtained independently from adenocarcinomas induced by 1,2 dimethylhydrazine in syngeneic BDIX rats (Martin et al, 1973 Recurrent tumours were excised from animals of both groups, 1, 2 or 3 times, according to the size of the tumour, to control the local tumour burden. The number of excisions was identical in both groups (2 rats once, 3 rats twice, and 3 rats thrice).…”

Section: Methodsmentioning

confidence: 99%

Ineffectiveness of levamisole as adjuvant to surgery with two lines of transplanted rat colonic carcinoma

Martin¹,

Justrabo²,

Martin³

et al. 1981

Br J Cancer

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“…Transplantable colonic tumours Tumour DHD is a transplantable well differentiated carcinoma originating in a colonic tumour induced by 1,2 dimethylhydrazine in a BDIX rat (Martin et al, 1973). It was maintained by s.c. implantation in syngeneic rats.…”

Section: Animalsmentioning

confidence: 99%

“…To determine the lipidic composition of the biscuits, lipids were extracted according to Folch et al, (1957) and the fatty acids were analyzed by gas-liquid chromatography as their methyl ester derivatives. The mean fatty acid content was 4.3% of the biscuit weight, unsaturated fatty acids and linoleic acid being respectively 60% and 21% of the total fatty acids.Transplantable colonic tumours Tumour DHD is a transplantable well differentiated carcinoma originating in a colonic tumour induced by 1,2 dimethylhydrazine in a BDIX rat (Martin et al, 1973). It was maintained by s.c. implantation in syngeneic rats.…”

mentioning

confidence: 99%

Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat

Caignard¹,

Martin²,

Reisser³

et al. 1984

Br J Cancer

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Summary The effects of cimetidine and indomethacin on the growth of dimethylhydrazine induced or transplanted intestinal tumours in the rat have been studied. Cimetidine is a histamine type 2 receptor antagonist and indomethacin is an inhibitor of prostaglandin synthesis. Two models of rat intestinal tumours were used: a colon carcinoma line transplantable in syngeneic animals and intestinal tumours induced by dimethylhydrazine treatment of Sprague-Dawley rats. Cimetidine and indomethacin were given in drinking water, alone or in combination. Cimetidine had no effect on the growth of transplanted colon cancer but significantly increased the incidence of chemically-induced tumours, with a tendency toward more invasive and metastatic tumours than in the control animals. Indomethacin did not significantly modify the incidence or other characteristics of the tumours in any of the models. This result is at variance with a protective effect of indomethacin on chemically-induced rat colon cancer previously reported by others.In spite of numerous attempts, treatment of advanced or residual colorectal cancer by cytotoxic agents can be considered a failure. Since surgery is efficient only in the early forms of disease, other methods of treatment need to be found. Two groups have recently reported that indomethacin, a potent inhibitor of prostaglandin synthesis, was able to inhibit the growth of intestinal tumours indiced by a,variety of carcinogenec agents in the rat (Pollard & Luckert, 1980;Kudo et al., 1980). It has also been reported that cimetidine, a histamine type-2 receptor antagonist widely used in the treatment of peptic ulcer, could inhibit the growth of experimental tumours in rodents. This could perhaps occur through its blocking effect on histamine H-2 receptors at the surface of suppressor T lymphocytes (Gifford et al., 1981;Osband et al., 1981).Because indomethacin and cimetidine could have a cooperative effect on tumour growth, the efficiency of both drugs was tested individually or in combination, on experimental intestinal cancer. Two models were used in this work: a colon carcinoma line transplantable in syngeneic BDIX strain rats and intestinal tunours induced by dimethylhydrazine in Sprague-Dawley rats. Materials and methods AnimalsTwo strains of syngeneic rats were used in this Correspondence: A. Caignard Received 28 March 1984; accepted 16 July 1984. work: BDIX rats, bred in our laboratory by brother-sister mating, and Sprague-Dawley rats (IFFA-Credo, L'Arbresle, France). They were kept in an air-conditioned, humidity-controlled room, with a Light-dark cycle of 12h. They were allowed drinking water ad libidum and fed Extralabo biscuits (Sainte-Colombe, France). To determine the lipidic composition of the biscuits, lipids were extracted according to Folch et al., (1957) and the fatty acids were analyzed by gas-liquid chromatography as their methyl ester derivatives. The mean fatty acid content was 4.3% of the biscuit weight, unsaturated fatty acids and linoleic acid being respectively 60% and 21%...

show abstract

An Experimental Model for Cancer of the Colon and Rectum

Cited by 76 publications

References 5 publications

Corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats

Corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats

Ineffectiveness of levamisole as adjuvant to surgery with two lines of transplanted rat colonic carcinoma

Effects of cimetidine and indomethacin on the growth of dimethylhydrazine-induced or transplanted intestinal cancers in the rat

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