Morphologic and Histologic Comparison Between the Patella and Hamstring Tendons Grafts: A Descriptive and Anatomic Study

Hadjicostas, Panayiotis T.; Soucacos, Panayotis N.; Paessler, Hans H.; Koleganova, Nadezda; Berger, Irina

doi:10.1016/j.arthro.2007.02.002

Cited by 34 publications

(37 citation statements)

References 37 publications

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“…However, the published data arises from the comparison of tendinopathic tissue with either control tissue from different anatomical tendons [17] or with tissues from identical anatomical tendons but from different subjects [18]. Since considerable microscopic structure differences have been demonstrated in anatomically different tendons [19], this limits the conclusions that may be drawn from these studies. Taking the aforementioned limitations into account, current data concerning local biochemical differences within tendinopathic tendons, seem to indicate that an altered expression of collagen [20], proteoglycans [21] and matrix metalloproteinases [16,22] exists in tendinopathic tendons.…”

Section: Introductionmentioning

confidence: 99%

Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

Pingel

Fredberg

Qvortrup

et al. 2012

BMC Musculoskelet Disord

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Background The incidence of Achilles tendinopathy is high and underlying etiology as well as biochemical and morphological pathology associated with the disease is largely unknown. The aim of the present study was to describe biochemical and morphological differences in chronic Achilles tendinopathy. The expressions of growth factors, inflammatory mediators and tendon morphology were determined in both chronically diseased and healthy tendon parts. Methods Thirty Achilles tendinopathy patients were randomized to an expression-study ( n = 16) or a structural-study ( n = 14). Biopsies from two areas in the Achilles tendon were taken and structural parameters: fibril density, fibril size, volume fraction of cells and the nucleus/cytoplasm ratio of cells were determined. Further gene expressions of various genes were analyzed. Results Significantly smaller collagen fibrils and a higher volume fraction of cells were observed in the tendinopathic region of the tendon. Markers for collagen and its synthesis collagen 1, collagen 3, fibronectin, tenascin-c, transforming growth factor-β fibromodulin, and markers of collagen breakdown matrix metalloproteinase-2, matrix metalloproteinase-9 and metallopeptidase inhibitor-2 were significantly increased in the tendinopathic region. No altered expressions of markers for fibrillogenesis, inflammation or wound healing were observed. Conclusion The present study indicates that an increased expression of factors stimulating the turnover of connective tissue is present in the diseased part of tendinopathic tendons, associated with an increased number of cells in the injured area as well as an increased number of smaller and thinner fibrils in the diseased tendon region. As no fibrillogenesis, inflammation or wound healing could be detected, the present data supports the notion that tendinopathy is an ongoing degenerative process. Trial registration Current Controlled Trials ISRCTN20896880

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Section: Introductionmentioning

confidence: 99%

Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

Pingel

Fredberg

Qvortrup

et al. 2012

BMC Musculoskelet Disord

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“…Hadjicostas et al,23 compared the histological features of the patellar tendon and semitendinosus and gracilis tendons in cadavers. Differences were found in the relationship between fibrils/interstitium (20 to 30% higher in the flexor) and density of fibroblasts (35 to 50%).…”

Section: Discussionmentioning

confidence: 99%

“…Like the work of Hadjicostas et al,23 we included bodies of both sexes. Limiting the age of the cadavers in this study served to remove the degenerative effects that can be seen after age 40 as a result of tissue aging, and also to reduce the risk of injuries and disruptions to which aging individuals are naturally predisposed.…”

Section: Discussionmentioning

confidence: 99%

Histological Study of Fresh Versus Frozen Semitendinous Muscle Tendon Allografts

Bitar

Santos

Croci

et al. 2010

Clinics

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OBJECTIVE:The purpose of this study was to histologically analyze allografts from cadaveric semitendinous muscle after cryopreservation at −80°C in comparison to a control group kept at only −4°C to test the hypothesis that the histological characteristics of the tissue are maintained when the tendons are kept at lower temperatures.METHODS:In a tissue bank, 10 semitendinous tendons from 10 cadavers were frozen at −80ºC as a storage method for tissue preservation. They were kept frozen for 40 days, and then a histological study was carried out. Another 10 tendon samples were analyzed while still “fresh”.RESULTS:There was no histological difference between the fresh and frozen samples in relation to seven variables.CONCLUSIONS:Semitendinous muscle tendon allografts can be submitted to cryopreservation at −80ºC without suffering histological modifications.

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“…It has been suggested [ 12 ] that the ST tendon has a better potential of remodelling than the patellar tendon due to its signifi cantly higher density of collagen fi brils and fi broblasts and that the surgical method "stripping" when harvesting the tendons plays an important role in the regenerative process [ 24 ] since synovial cells possess the ability to differentiate when subjected to mechanical stress. Eriksson et al [ 8 ] proposed that the initially formed haematoma, also described by Papandrea et al [ 27 ], that occupies the harvest defect acts as a scaffold for fi brocyte migration and the subsequent tendon regeneration.…”

Section: How Does the Tendonmentioning

confidence: 99%

Semitendinosus and Gracilis Tendon Regeneration Following Harvest

Åhlén

Lidén

Kartus

2014

Anterior Cruciate Ligament Reconstruction

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Studies have shown that the semitendinosus (ST) and gracilis (G) tendons are able to regenerate after harvest, and probably they are the only known tendons in the human body that can regenerate after harvest of the whole tendon from the musculotendinous junction all the way to the insertion. This chapter will focus on the existing knowledge about the ST and G tendon regeneration frequency, quality of the regenerated tendon, level of insertion, cross-sectional area and weakness in fl exion and internal rotation of the knee after harvest. What the Diagnostic Methods Have Shown: The Regeneration Rate and MorphologyIn 1992 Cross et al. [ 6 ] were the fi rst to report that the ST and G tendons could regenerate after examining patients with magnetic resonance imaging (MRI). These fi ndings have subsequently been verifi ed using MRI [ 2 , 5 , 7 , 9 , 13 , 18 , 28 , 30 , 33 ]

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Morphologic and Histologic Comparison Between the Patella and Hamstring Tendons Grafts: A Descriptive and Anatomic Study

Cited by 34 publications

References 37 publications

Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

Local biochemical and morphological differences in human Achilles tendinopathy: a case control study

Histological Study of Fresh Versus Frozen Semitendinous Muscle Tendon Allografts

Semitendinosus and Gracilis Tendon Regeneration Following Harvest

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