Morphologic and functional alterations of erythroid cells induced by long-term ingestion of aluminium

Vittori, Daniela; Nesse, Alcira; Pérez, Gladys; Garbossa, Graciela

doi:10.1016/s0162-0134(99)00122-1

Cited by 56 publications

(38 citation statements)

References 18 publications

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“…26 By contrast, chronic hematological effects are observed at plasma aluminum concentrations of about 100 μg/L along with the onset of reversible hypochromic anemia in dialysis patients caused by the direct effects of aluminum on erythrocyte progenitors and possibly, an additional chelation effect; this effect would account for the difficulties encountered when trying to correct the anemia of geophagous individuals by iron supplementation. [29][30][31] The lack of correlation between hemoglobin and aluminum concentrations suggests that aluminum played only a minor role in the anemia of our patients, at least for concentrations of 10-100 μg/L. Neurocognitive problems and subtle electroencephalographic changes have been observed in aluminum workers with urinary aluminum concentrations of the order of 41 μg/L, a level reached in one-third of our patients.…”

Section: Discussionmentioning

confidence: 92%

Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Lambert¹,

Boukhari²,

Nacher³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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The clays consumed by geophagous individuals contain large quantities of aluminum, a known neurological and hematological toxin. This is the first study to evaluate the risk of aluminum poisoning in geophagous individuals. Blind determinations of plasma and urinary aluminum concentrations were carried out in 98 anemic geophagous pregnant women and 85 non-anemic non-geophagous pregnant women. Aluminum concentrations were significantly higher (P < 0.0001) in the geophagous anemic women than in the controls, with odds ratios of 6.83 (95% confidence interval [CI] = 2.72–19.31) for plasma concentrations (13.92 ± 14.09 μg/L versus 4.95 ± 7.11 μg/L) and 5.44 (95% CI = 2.17–14.8) for urinary concentrations (92.83 ± 251.21 μg/L versus 12.11 ± 23 μg/L). The ingested clay is the most likely source of this overexposure to aluminum. If confirmed, the clinical consequences of this absorption for pregnant women and their offspring should be explored.

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Section: Discussionmentioning

confidence: 92%

Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Lambert¹,

Boukhari²,

Nacher³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…Inhibition of erythroid progenitor cells by Al has been demonstrated by both in vitro and in vivo assays. Severe morphological changes of erythrocytes were induced by Al, and traces of the metal were detected inside cells with abnormal shape [274] or attached to the erythrocyte membrane [275]. Al toxicity continues to be a problem for chronic hemodialysis patients.…”

Section: Induction Of Interfacial Water Stressmentioning

confidence: 99%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

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This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the "problems" of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater "stiffness" in the extracellular matrix and either the "soft" cancerous state or the "soft" neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal. OPEN ACCESSEntropy 2013, 15 3823

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“…Samples were prepared as previously reported [Vittori et al, 1999]. Briefly, cells (2 Â 10 5 cells/ml) were seeded on a glass support (50 mm 2 area), and after exposure to different treatments, were fixed for 20 min with 3% (v/v) glutardialdehyde in 0.1 M-pH 7.4 phosphate buffer.…”

Section: Assessment Of Cellular Morphology By Scanning Electron Micromentioning

confidence: 99%

Differential antiapoptotic effect of erythropoietin on undifferentiated and retinoic acid‐differentiated SH‐SY5Y cells

Wenker

Chamorro

Vota

et al. 2010

J of Cellular Biochemistry

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Erythropoietin (Epo) is known to have a significant role in tissues outside the hematopoietic system. In this work, we investigated the function of Epo in cells of neuronal origin subjected to differentiation. Treatment of SH-SY5Y cells with all-trans-retinoic acid (atRA) generated differentiated neuron-like cells, observed by increased expression of neuronal markers and morphological changes. Exposure of undifferentiated cells to proapoptotic stimuli such as staurosporine, TNF-alpha, or hypoxia, significantly increased programmed cell death, which was prevented by previous treatment with Epo. In contrast, atRA-differentiated cultures showed cell resistance to apoptosis. No additional effect of Epo was detected in previously differentiated cells. The inhibition of the PI3K/Akt pathway by Ly294002 abrogated the protective effects induced by either Epo or atRA. The effect of atRA was mediated by an increased expression of Bcl-2 whereas the Epo treatment upregulated not only Bcl-2 but also Bcl-xL. This upregulation by Epo was not detected in atRA-differentiated cells, thus confirming the lack of the protective effect of Epo. As expected, assays with AG490, an inhibitor of Jak2, blocked the Epo action only in undifferentiated cells. This reduced neuroprotective function of Epo on SH-SY5Y differentiated cells could be explained at least in part by downregulation of the Epo receptor expression, which was observed in atRA-differentiated cells. This study shows differential cellular protection induced by Epo at two stages of SH-SY5Y differentiation. The results allow us to suggest that this differential cell behavior can be ascribed to the interaction between atRA and the signaling pathways mediated by Epo.

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Morphologic and functional alterations of erythroid cells induced by long-term ingestion of aluminium

Cited by 56 publications

References 18 publications

Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Differential antiapoptotic effect of erythropoietin on undifferentiated and retinoic acid‐differentiated SH‐SY5Y cells

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