Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Lambert, Véronique; Boukhari, Rachida; Nacher, Mathieu; Goullé, Jean-Pierre; Roudier, Estelle; Elguindi, Wael; Laquerrière, Annie; Carles, Gabriel

doi:10.4269/ajtmh.2010.10-0370

Cited by 23 publications

(8 citation statements)

References 29 publications

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“…The mean Al serum level in pregnant women at delivery in our study was 10.1 μg/L with an overall median of 6.79 μg/L, which is above the ATSDR guidance. These results are comparable to the 13.92 ± 14.09 μg/L concentrations of Al in plasma, which were measured in a cohort of pregnant women practicing the ancestral cultural custom of ingestion of earth (geophagy) in French Guiana [ 31 ]. A comparable study measured Al in maternal blood in Japanese women and the Al levels reported were 7.83 μg/L [ 32 ].…”

Section: Discussionsupporting

confidence: 79%

Prenatal Exposure to Aluminum and Status of Selected Essential Trace Elements in Rural South African Women at Delivery

Röllin

Nogueira

Olutola

et al. 2018

IJERPH

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This study sought to evaluate the in utero exposure to aluminum and status of selected trace elements in South African women at delivery since aluminum is known to be toxic in all developmental stages even at low concentrations. Serum aluminum was negatively correlated with aluminum in urine, both uncorrected and corrected for creatinine, which suggests the retention of aluminum in body stores. Serum copper and zinc levels were found to be high in this study population. Serum copper levels were negatively correlated with aluminum in serum (β = −0.095; p = 0.05). There was a marginal negative correlation between aluminum levels in serum and manganese levels in whole blood (β = −0.087; p = 0.08). Copper levels in maternal serum were negatively correlated with birth weight and the length of neonates. There were a number of positive correlations between maternal characteristics and birth outcomes. Mothers who consumed root vegetables frequently appeared to be protected from aluminum retention and increased body burden since their serum aluminum levels were found to be significantly lower. The findings of the current study can be used as a baseline for further research on aluminum exposure and its associated interactions and outcomes in vulnerable populations.

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Section: Discussionsupporting

confidence: 79%

Prenatal Exposure to Aluminum and Status of Selected Essential Trace Elements in Rural South African Women at Delivery

Röllin

Nogueira

Olutola

et al. 2018

IJERPH

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“…The present paper showed that in French Guiana the incidence of death from congenital malformations of the cardiovascular and neurological system was significantly higher than in mainland France. There are several potential explanations for this high incidence of deaths from congenital malformations: infections during pregnancy [14, 20, 21], exposure to toxic metals [13, 22, 23], fetal alcohol syndrome, diabetes, nutritional deficiencies, social precariousness, preterm birth [8], and endogamy [9, 11]. The policy implications of this observation are that spontaneous abortions, stillbirths, and congenital malformations, should be the focus of specific individual data collection to better describe their nature.…”

Section: Discussionmentioning

confidence: 99%

High mortality due to congenital malformations in children aged < 1 year in French Guiana

et al. 2018

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BackgroundIn French Guiana, pregnant women may be exposed to infectious, environmental, and social risks leading to congenital malformation. The objective of the study was to study mortality rates from congenital malformations among infants < 1 year and to compare them with those in mainland France.MethodsWe used the CEPI DC (INSERM) database, which compiles annual data from death certificates in all French territories using the International Classification of Diseases. Annual deaths for French Guiana and mainland France between 2005 and 2015 were compiled. The age category studied was children less than 1 year and deaths from congenital malformations, deformations and chromosomal abnormalities were compiled. Crude risk ratios and 95% confidence intervals were calculated to quantify the excess risk of disease in French Guiana.ResultsIn French Guiana between 2005 and 2015 there were 666 deaths of children aged < 1 year, among which, 132 (19.8%) were due to congenital malformations and chromosomal anomalies. Overall the risk ratio of death from congenital malformations and chromosomal anomalies between French Guiana and mainland France was 2.7 (1.5–4.7), P < 0.001 for neurological congenital malformations it was 4.8 (1.2–19.7), P = 0.01 and for congenital malformations of the circulatory system it was 3.3 (1.5–6.9), P = 0.001.ConclusionsThe incidence of death from congenital malformations or chromosomal anomalies in French Guiana was significantly higher than in mainland France. Explanations for this may be infections, genetic causes, nutritional causes, and toxic causes that are prevalent. There is a need to identify factors that predispose children born in French Guiana to having a higher risk of congenital malformations and chromosomal anomalies.

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“…Moreover, copper has reportedly been linked to genomic instability, which is related to breast cancer in rats [21], whereas cadmium is related to breast cancer in women worldwide [22]. Furthermore, aluminum chloride is being investigated for its potential relationship with neurological, hepatic, bone, and hematological conditions as well as with breast cancer [23][24][25][26][27]. Therefore, we assessed the genotoxic effects of aluminum concentration in Sprague Dawley rats and determined whether a link could be established with N-nitroso-N-methylurea (NMU)-induced breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Effects of Aluminum Chloride and Their Relationship with N-Nitroso-N-Methylurea (NMU)-Induced Breast Cancer in Sprague Dawley Rats

García-Alegría

Gómez-Álvarez

Anduro-Corona

et al. 2020

Toxics

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Recently, soluble forms of aluminum for human use or consumption have been determined to be potentially toxic due to their association with hepatic, neurological, hematological, neoplastic, and bone conditions. This study aims to assess the genotoxic effect of aluminum chloride on genomic instability associated with the onset of N-nitroso-N-methylurea (NMU)-induced breast cancer in Sprague Dawley rats. The dietary behavior of the rats was assessed, and the concentration of aluminum in the mammary glands was determined using atomic absorption spectroscopy. Genomic instability was determined in the histological sections of mammary glands stained with hematoxylin and eosin. Moreover, micronucleus in peripheral blood and comet assays were performed. The results of dietary behavior evaluation indicated no significant differences between the experimental treatments. However, aluminum concentration in breast tissues was high in the +2000Al/−NMU treatment. This experimental treatment caused moderate intraductal cell proliferation, lymph node hyperplasia, and serous gland adenoma. Furthermore, micronucleus and comet test results revealed that +2000Al/−NMU led to a genotoxic effect after a 10-day exposure and the damage was more evident after a 15-day exposure. Therefore, in conclusion, genomic instability is present and the experimental conditions assessed are not associated with breast cancer.

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Plasma and Urinary Aluminum Concentrations in Severely Anemic Geophagous Pregnant Women in the Bas Maroni Region of French Guiana: A Case-Control Study

Cited by 23 publications

References 29 publications

Prenatal Exposure to Aluminum and Status of Selected Essential Trace Elements in Rural South African Women at Delivery

Prenatal Exposure to Aluminum and Status of Selected Essential Trace Elements in Rural South African Women at Delivery

High mortality due to congenital malformations in children aged < 1 year in French Guiana

Genotoxic Effects of Aluminum Chloride and Their Relationship with N-Nitroso-N-Methylurea (NMU)-Induced Breast Cancer in Sprague Dawley Rats

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