Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial

Long, Joanna; Drayson, Mark T.; Taylor, Angela E.; Toellner, Kai‐Michael; Lord, Janet M.; Phillips, Anna C.

doi:10.1016/j.vaccine.2016.04.032

Cited by 224 publications

(205 citation statements)

References 25 publications

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“…has recently been shown to be a determinant in the systemic immunization response in people aged >65 y (24 Cell Culture and Bioluminescence Assays. Primary fibroblasts were generated as described previously (27).…”

Section: Discussionmentioning

confidence: 99%

Cell autonomous regulation of herpes and influenza virus infection by the circadian clock

Edgar

Stangherlin

Nagy

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

192

219

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Viruses are intracellular pathogens that hijack host cell machinery and resources to replicate. Rather than being constant, host physiology is rhythmic, undergoing circadian (∼24 h) oscillations in many virus-relevant pathways, but whether daily rhythms impact on viral replication is unknown. We find that the time of day of host infection regulates virus progression in live mice and individual cells. Furthermore, we demonstrate that herpes and influenza A virus infections are enhanced when host circadian rhythms are abolished by disrupting the key clock gene transcription factor Bmal1. Intracellular trafficking, biosynthetic processes, protein synthesis, and chromatin assembly all contribute to circadian regulation of virus infection. Moreover, herpesviruses differentially target components of the molecular circadian clockwork. Our work demonstrates that viruses exploit the clockwork for their own gain and that the clock represents a novel target for modulating viral replication that extends beyond any single family of these ubiquitous pathogens.circadian | clock | virus | herpes | influenza

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Section: Discussionmentioning

confidence: 99%

Cell autonomous regulation of herpes and influenza virus infection by the circadian clock

Edgar

Stangherlin

Nagy

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

192

219

View full text Add to dashboard Cite

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“…Timing chemotherapy infusions with circadian rhythms in patients with metastatic colorectal cancer increased the effectiveness of chemotherapy and significantly reduced toxic side-effects compared to conventional constant-rate infusion [33] Vaccination 276 patients (over 65 years of age) vaccinated in the morning had greater antibody titers 1 month later than patients vaccinated in the afternoon.…”

Section: Molecular Clockmentioning

confidence: 99%

“…In 2017, the Nobel Prize in Physiology or Medicine was awarded jointly to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young ''for their discoveries of molecular mechanisms controlling the circadian rhythm'' [1][2][3]. The circadian clock is crucial in regulating daily physiological processes and it is now realized that the time at which our immune system is triggered (by infection [4], vaccination [5], surgery [6]), appears to be critical to the way we respond to these insults. Several inflammatory diseases, such as asthma, display a marked time of day pattern in symptoms.…”

Section: Introductionmentioning

confidence: 99%

The Role of the Body Clock in Asthma and COPD: Implication for Treatment

Krakowiak

Durrington

2018

Pulm Ther

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Asthma exhibits a marked time of day variation in symptoms, airway physiology, and airway inflammation. This is also seen in chronic obstructive pulmonary disease (COPD), but to a lesser extent. Our understanding of how physiological daily rhythms are regulated by the circadian clock is increasing, and there is growing evidence that the molecular clock is important in the pathogenesis of these two airway diseases. If time of day is important, then it follows that treatment of asthma and COPD should also be tailored to the most efficacious time of the day, a concept known as 'chronotherapy'. There have been a number of studies to determine the optimal time of day at which to take medications for asthma and COPD. Some of these agents are already used 'chronotherapeutically' in practice (often at night-time). However, several studies investigating systemic and inhaled corticosteroids have consistently shown that the best time of day to take these medications for treating asthma is in the afternoon or early evening and not in the morning, when these medications are often prescribed. Future, large, randomized, placebo-controlled studies of systemic and inhaled corticosteroids in asthma and COPD are needed to inform clinical practice.

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“…Mice immunized with CpG, a TLR9 ligand, at ZT19 display an increased lymphocyte proliferative response and heightened IFN␥ [82]. Human data indicates that the efficiency of certain serotypes of the influenza vaccine in elderly subjects might be modulated by time-of-day administration [83]. Antibody titres against the vaccine were greatest in subjects vaccinated in the morning versus the afternoon.…”

Section: Bmal1-a Master Regulatormentioning

confidence: 99%