Immunometabolism: Is it under the eye of the clock?

Early, James O.; Curtis, Anne M.

doi:10.1016/j.smim.2016.10.006

Cited by 46 publications

(38 citation statements)

References 157 publications

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“…Life on Earth follows a 24-h rhythm that is largely entrained by daily oscillations in light, due to the earth’s axial rotation ( 1 ). Cellular molecular clocks dictate variations in physiology and behavior that peak and trough within this 24-h timescale, termed circadian rhythms.…”

mentioning

confidence: 99%

“…BMAL1 is the core orchestrator of the molecular clock, and the only single clock gene deletion that leads to complete ablation of all rhythms. BMAL1 forms a heterodimeric partnership with CLOCK and binds to E-box sites located across the genome, inducing rhythmic expression in clock-controlled genes ( 1 ). Circadian rhythms are orchestrated by the master clock, which resides in the suprachiasmatic nucleus (SCN) of the hypothalamus.…”

mentioning

confidence: 99%

“…Circadian rhythms are orchestrated by the master clock, which resides in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN clock keeps peripheral clocks in synchrony with the external environment ( 1 ). This system provides circadian rhythms across a range of biological processes, including hormone secretion ( 2 ), metabolism ( 1 ), and immune function ( 1 ).…”

mentioning

confidence: 99%

“…There is now a growing body of evidence that cells of the innate immune system, such as macrophages, possess molecular clocks ( 1 ). These endogenous clocks impose temporal gating across a range of functions, including phagocytosis ( 3 ), cytokine production ( 4 ), and antibacterial ( 5 ) and antiviral activity ( 6 ).…”

mentioning

confidence: 99%

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Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

Early

Menon

Wyse

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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SignificanceThe molecular clock provides an anticipatory mechanism, allowing organisms to prepare and respond to daily changes in the external environment. The response of the innate immune system to pathogenic threats is dependent on time of day; however, the molecular mechanisms underlying this have yet to be fully uncovered. We observe that the core molecular clock component, BMAL1, is crucial in promoting an antioxidant response in myeloid cells. Deletion of Bmal1 in macrophages disrupts NRF2 activity, facilitating accumulation of reactive oxygen species and the proinflammatory cytokine, IL-1β. Thus the molecular clock directly controls NRF2 transcriptional activity and antioxidant capacity to regulate IL-1β in myeloid cells.

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confidence: 99%

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confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

Early

Menon

Wyse

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

239

190

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“…In contrast to REV-ERBs, RORs often function as transcriptional activators and their expression correlates with histone acetylation and chromatin accessibility [97]. RORs have a tissue specific distribution, with RORβ restricted to the brain and RORγ mainly in skeletal muscle [98]. RORα is broadly distributed in many peripheral tissues, including liver, smooth muscle, testes, and lymphocytes [99].…”

Section: Retinoic Acid Receptor-related Orphan Receptors (Rorα Rorβ mentioning

confidence: 99%

Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription

Zhang

Heaney

2020

Cells

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The hypothalamic–pituitary–adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal and stress related factors that synergistically interact to activate and temper pro-opiomelanocortin (POMC) transcription, to either increase or decrease adrenocorticotropic hormone (ACTH) production and secretion as needed. Nuclear receptors are a family of highly conserved transcription factors that can also be induced by various physiologic signals, and they mediate their responses via multiple targets to regulate metabolism and homeostasis. In this review, we summarize the modulatory roles of nuclear receptors on pituitary corticotroph cell POMC transcription, describe the unique and complex role these factors play in hypothalamic–pituitary–adrenal axis (HPA) regulation and discuss potential therapeutic targets in disease states.

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The circadian rhythm gene Bmal1 ameliorates acute deoxynivalenol-induced liver damage

Yang

Tang

et al. 2023

Arch Toxicol

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Immunometabolism: Is it under the eye of the clock?

Cited by 46 publications

References 157 publications

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription

The circadian rhythm gene Bmal1 ameliorates acute deoxynivalenol-induced liver damage

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