“…The remaining factors can recognize and compete for D-box motifs on promoters and enhancers, thus activating transcription in a redundant manner ( Fonjallaz et al, 1996 ; Gachon et al, 2004 , 2006 ). Therefore, this cascade coordinates the interaction between the positive and negative regulation of RORE and Reverb, and shapes the oscillating expression of Bmal1 ( Zhang and Heaney, 2020 ). An increasing body of evidence has demonstrated that circadian rhythms play pivotal roles in diverse physiological and pathological processes, including the cardiovascular system, energy metabolism, immunity, hormone secretion, and reproduction ( Panda, 2016 ; Pilorz et al, 2018 ; Krueger et al, 2020 ).…”