New insight into ischemic stroke: Circadian rhythm in post-stroke angiogenesis

Abstract

The circadian rhythm is an endogenous clock system that coordinates and optimizes various physiological and pathophysiological processes, which accord with the master and the peripheral clock. Increasing evidence indicates that endogenous circadian rhythm disruption is involved in the lesion volume and recovery of ischemic stroke. As a critical recovery mechanism in post-stroke, angiogenesis reestablishes the regional blood supply and enhances cognitive and behavioral abilities, which is mainly composed of the following processes: endothelial cell proliferation, migration, and pericyte recruitment. The available evidence revealed that the circadian governs many aspects of angiogenesis. This study reviews the mechanism by which circadian rhythms regulate the process of angiogenesis and its contribution to functional recovery in post-stroke at the aspects of the molecular level. A comprehensive understanding of the circadian clock regulating angiogenesis in post-stroke is expected to develop new strategies for the treatment of cerebral infarction.

Night shift work was associated with functional outcomes in acute ischemic stroke patients treated with endovascular thrombectomy

“…Promoting angiogenesis has been confirmed to be a critical recovery mechanism in ischemic stroke [ 29 ]. Recent studies have suggested that endothelial cells phenotypic processes could be regulated by brain and muscle Arnt-like 1 (Bmal1), the core circadian component [ 30 ], which promotes the proliferation, migration, and tube formation abilities of endothelial cells [ [31] , [32] , [33] ]. However, the expression of Bmal1 genes was lower in shift workers [ 34 ].…”

Efficacy and safety of blood-activating herbs combined with edaravone in the treatment of acute ischemic stroke: A protocol for systematic review and meta-analysis

“…A series of symptoms such as neurological dysfunction is induced. [14] Studies have shown that multiple pathways of injury in the ischemic cascade are simultaneous and interact with each other; therefore, combined therapy targeting several pathways of ischemic injury may have advantages over single pathway strategies. [15] Free radicals are the main cause of ischemic cerebrovascular injury, and the massive production of free radicals after brain tissue injury promotes secondary brain tissue damage.…”

“…A series of symptoms such as neurological dysfunction is induced. [14] Studies have shown that multiple pathways of injury in the ischemic cascade are simultaneous and interact with each other; therefore, combined therapy targeting several pathways of ischemic injury may have advantages over single pathway strategies. [15]…”

Circadian Factors in Stroke: A Clinician’s Perspective

“…Angiogenesis is an important factor for post-stroke recovery, and it is tightly related to the activation and functioning of glial cells [ 136 ]. Clock genes (in particular, Cry1/2 ) are involved in the regulation of different stages of the angiogenesis process [ 137 , 138 ].…”