The circadian rhythm gene Bmal1 ameliorates acute deoxynivalenol-induced liver damage

Yang, Liu-Nan; Xu, Simiao; Tang, Mingmeng; Zhou, Xiaolei; Liao, Yixiang; Nüssler, Andreas K.; Liu, Liegang; Yang, Wei

doi:10.1007/s00204-022-03431-x

Cited by 2 publications

(2 citation statements)

References 64 publications

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“…The DEGs involved in the Arachidonic acid metabolism and Circadian rhythm signaling pathway played regulatory roles in mycotoxin toxic effects [ 15 , 16 ]. A gene expression heat map showed that the expression of the genes involved in Arachidonic acid metabolism were significantly upregulated in the OTA group but downregulated in the OTA+CUR group, while the expression of the genes involved in the Circadian rhythm signaling pathway demonstrated a contrary trend ( Figure 2 F).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the downregulated expression of the genes related to the Circadian rhythm may be one of the routes that OTA induces hepatotoxicity. It is evidenced that the overexpression of the core component of the Circadian rhythm Bmal1 obviously attenuates mycotoxin-induced liver inflammation and liver injury [ 16 ]. Interestingly, the downregulated DEGs ( Dbp , Bhlhe41 , Per3 , and Per2 ) in the OTA group were significantly upregulated in the OTA+CUR group.…”

Section: Discussionmentioning

confidence: 99%

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Metabolomics and Transcriptomics Analyses of Curcumin Alleviation of Ochratoxin A-Induced Hepatotoxicity

Hui,

Zheng,

Dong

et al. 2023

IJMS

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Ochratoxin A (OTA) is one of the mycotoxins that poses a serious threat to human and animal health. Curcumin (CUR) is a major bioactive component of turmeric that provides multiple health benefits. CUR can reduce the toxicities induced by mycotoxins, but the underlying molecular mechanisms remain largely unknown. To explore the effects of CUR on OTA toxicity and identify the key regulators and metabolites involved in the biological processes, we performed metabolomic and transcriptomic analyses of livers from OTA-exposed mice. We found that CUR can alleviate the toxic effects of OTA on body growth and liver functions. In addition, CUR supplementation significantly affects the expressions of 1584 genes and 97 metabolites. Integrated analyses of transcriptomic and metabolomic data showed that the pathways including Arachidonic acid metabolism, Purine metabolism, and Cholesterol metabolism were significantly enriched. Pantothenic acid (PA) was identified as a key metabolite, the exogenous supplementation of which was observed to significantly alleviate the OTA-induced accumulation of reactive oxygen species and cell apoptosis. Further mechanistical analyses revealed that PA can downregulate the expression level of proapoptotic protein BAX, enhance the expression level of apoptosis inhibitory protein BCL2, and decrease the level of phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2). This study demonstrated that CUR can alleviate the adverse effects of OTA by influencing the transcriptomic and metabolomic profiles of livers, which may contribute to the application of CUR in food and feed products for the prevention of OTA toxicity.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metabolomics and Transcriptomics Analyses of Curcumin Alleviation of Ochratoxin A-Induced Hepatotoxicity

Hui,

Zheng,

Dong

et al. 2023

IJMS

View full text Add to dashboard Cite

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Natural Compounds for Preventing Age-Related Diseases and Cancers

Ki,

Youn,

Kim

et al. 2024

IJMS

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Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external and internal signs of aging manifest in various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative disorders, and cancer. Additionally, cancer, like aging, is a complex disease that arises from the accumulation of various genetic and epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for aging and cancer development. Natural compounds and herbal medicines have gained significant attention for their potential in preventing age-related diseases and inhibiting cancer progression. These compounds demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic effects as well as circadian clock regulation. This review explores age-related diseases, cancers, and the potential of specific natural compounds in targeting the key features of these conditions.

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The circadian rhythm gene Bmal1 ameliorates acute deoxynivalenol-induced liver damage

Cited by 2 publications

References 64 publications

Metabolomics and Transcriptomics Analyses of Curcumin Alleviation of Ochratoxin A-Induced Hepatotoxicity

Metabolomics and Transcriptomics Analyses of Curcumin Alleviation of Ochratoxin A-Induced Hepatotoxicity

Natural Compounds for Preventing Age-Related Diseases and Cancers

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