Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema

Abstract

Morinda citrifolia Linn. (Rubiaceae) leaves have been used in tropical folk medicine to treat topical inflammation and burns. A carbomer gel base, containing the ethanol extract and juice pressed from the leaves, was evaluated for potential allergenic properties in a repeat-insult patch test in 49 volunteers. To investigate the topical photo-protective properties, the combined ethanol extract and leaf juice were evaluated in a UVB-induced erythema model in 25 volunteers. The crude ethanol extract of M. citrifolia leaves was also evaluated in vitro for potential anti-inflammatory activity in a histamine H-1 receptor antagonism assay. There was no evidence of allergenic potential in the repeat-insult patch test. When the combination of ethanol extract and leaf juice was applied, the UVB dose required to induce erythema was almost 3.5 times greater than with untreated skin (P < 0.001). In the histamine H-1 receptor-binding assay, the crude ethanol extract of M. citrifolia leaves inhibited receptor binding by 57%. These results suggest that M. citrifolia leaves are safe for topical use and may be useful in mitigating UVB-induced injury to the skin.

Health Benefits of Morinda citrifolia (Noni): A Review

“…Study suggests that leaves are safe for topical use and may be useful in mitigating UVB-induced injury to the skin. 90 Effect on skin care regimen Six week clinical trial of Noni based skin care regimen on 49 women, (age 38 to 55 years). Where in the subjects applied three formulations of Noni i.e.…”

Peran Ekstrak Etanol Topikal Daun Mengkudu (Morinda citrifolia L.) pada Penyembuhan Luka Ditinjau dari Imunoekspresi CD34 dan Kolagen pada Tikus Galur Wistar

“…2,5 Bahan aktif yang terdapat pada daunnya yaitu saponin, triterpen, tanin, alkaloid, glikosida iridoid, dan flavonoid. 2,6,7 Efek utama senyawa kimia dalam daun mengkudu yang berhubungan dengan proses penyembuhan luka antara lain saponin sebagai antibakteri, tanin sebagai hemostatik serta astringensia, alkaloid berguna sebagai analgetik, dan senyawa glikosida iridoid sebagai antiinflamasi, sedangkan flavonoid sebagai antioksidan dan antiinflamasi. 2,[6][7][8][9] Penggunaan ekstrak etanol daun mengkudu per oral membantu mempercepat penyembuhan pada model perlukaan tikus.…”

“…2,6,7 Efek utama senyawa kimia dalam daun mengkudu yang berhubungan dengan proses penyembuhan luka antara lain saponin sebagai antibakteri, tanin sebagai hemostatik serta astringensia, alkaloid berguna sebagai analgetik, dan senyawa glikosida iridoid sebagai antiinflamasi, sedangkan flavonoid sebagai antioksidan dan antiinflamasi. 2,[6][7][8][9] Penggunaan ekstrak etanol daun mengkudu per oral membantu mempercepat penyembuhan pada model perlukaan tikus. 2,5 Daun mengkudu kering yang ditumbuk dan diaplikasikan secara topikal juga diketahui dapat mempercepat proses epitelisasi pada luka insisi tikus, serta ekstrak airnya mengurangi eritema yang diakibatkan paparan sinar ultraviolet B (UVB).…”

The Effect of Ethanol Extract Of Sarang Semut Plant (Hypnophytum Formicarum) to Granulation Tissue for Wound Healing After Teeth Extraction Experimental Research on Marmot (Cavia cobaya)

“…11,12 Flavonoids as antibacterial, antiinflammatory and antioxidant, antibacterial saponins, tannins as a hemostatic and astringent and alkaloids as an analgesic. 13,14 The aim of this study was to determine the effect of ethanol extract of the root of sarang semut as formulation of granulation tissue on wound healing after tooth extraction. The extract of sarang semut's root was obtained by peeling the root, sliced thinly (3-5 mm), dried in oven (temp500C) to obtain the dry root and easily broken for, then blended up into a coarse powder escaped sieve no.…”