Abstract:We report a case of severe Morbihan syndrome (chronic erythematous edema of the upper portion of the face) in a 60-year-old man. The syndrome was characterized clinically by erythematous edema involving the forehead, glabella, and both eyelids, because of which the patient was not able to open completely his eyes. Furthermore, erythema and telangiectasiae were visible on the nose and cheeks. Laboratory and instrumental examinations were within normal ranges or negative. Histopathological examination showed der… Show more
“…Marked infiltration of mast cells was observed in our case and in some previously reported cases (7,13), but not in other cases (1,2). The difference may depend on the stage of the disease and the way skin biopsies were taken.…”
Section: Successful Treatment Of Morbihan Disease With Long-term Minocontrasting
confidence: 70%
“…The pathogenesis of Morbihan disease is still unclear; it is either considered as a rare latestage complication of rosacea/acne or as a distinct entity (2,4). There was no previous history of rosacea in our case.…”
Section: Discussionmentioning
confidence: 49%
“…The term Morbihan disease was derived from the French region where the first patient was observed (2,3). Clinical features include nonpitting oedema and erythema particularly on the forehead, gla bella, eyelids, nose, and cheeks (4).…”
“…Marked infiltration of mast cells was observed in our case and in some previously reported cases (7,13), but not in other cases (1,2). The difference may depend on the stage of the disease and the way skin biopsies were taken.…”
Section: Successful Treatment Of Morbihan Disease With Long-term Minocontrasting
confidence: 70%
“…The pathogenesis of Morbihan disease is still unclear; it is either considered as a rare latestage complication of rosacea/acne or as a distinct entity (2,4). There was no previous history of rosacea in our case.…”
Section: Discussionmentioning
confidence: 49%
“…The term Morbihan disease was derived from the French region where the first patient was observed (2,3). Clinical features include nonpitting oedema and erythema particularly on the forehead, gla bella, eyelids, nose, and cheeks (4).…”
“…The edema worsens gradually over months to years with a solid consistency. The patient has no other symptomatic complaints and neither specific laboratory nor histopathologic findings have been observed [23]. The chronic nature of the skin condition, together with the restricted location, should differentiate this from angioedema.…”
Background: Angioedema is a vascular reaction involving the lower dermis, subcutis and/or submucosal tissue and causing a temporary localized swelling in any part of the body. For many health care professionals, the diagnosis presents an ongoing challenge; several disorders may manifest with subcutaneous or submucosal swelling and falsely be assumed to be angioedema. The clinicians at the emergency department and in the immunology/allergy clinics must be skilled at recognizing the features of angioedema and its differential diagnosis. Methods: The review is based on a literature search with specific indexing terms in PubMed, a review of bibliographies and the authors' clinical experience. Results: The most essential diseases that mimic angioedema, the so-called pseudoangioedemas, will each be discussed and illustrated by clinical photos, pointing out key features that help clarify the diagnoses and differentiate these from classic angioedema. Conclusions: A variety of dermatologic conditions can cause swelling that resembles angioedema, some with a potentially fatal outcome if misdiagnosed. Knowledge of pseudoangioedema is fundamental in the emergency setting when handling patients with edema and should be kept in mind when assessing an atypical angioedema case.
“…Reported therapies include systemic corticosteroids, tetracyclines, isotretinoin, clofazimine and ketotifen. Excision of redundant edematous tissue is a surgical alternative treatment [21].…”
Angioedema is a rapid, localized and temporary subcutaneous edema, which targets the lips, eyelids, gastrointestinal and respiratory mucosa resulting in abdominal pain, asthma and even serious life-threatening conditions like airway obstruction. There are several other disorders such as allergic contact dermatitis, drug rash with eosinophilia and systemic symptoms (DRESS), superior vena cava syndrome (SVCS), orofacial granulomatosis and so on, which manifest with subcutaneous swelling and masquerade as angioedema and are known as 'pseudoangioedema' in the literature. Knowledge of pseudoangioedema for healthcare professionals is crucial to avoid potentially serious results of misdiagnosis such as further investigations, unnecessary applications and delayed diagnosis. We aim to discuss differential diagnosis of angioedema and help physicians recognize the typical features of angioedema and its differential diagnosis in this chapter.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.