Successful Treatment of Morbihan Disease with Long-term Minocycline and its Association with Mast Cell Infiltration

Fujimoto, Noriki; Mitsuru, Mariko; Tanaka, Toshihiro

doi:10.2340/00015555-1954

Cited by 25 publications

(29 citation statements)

References 12 publications

(23 reference statements)

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“…Pitting edema remained in the previous case probably due to the delay of the initiation of minocycline treatment; however, the present case achieved a significant improvement without leaving pitting edema. Although further investigation is needed, the present case is compatible with our speculation that the long‐term use of tetracycline is effective in cases with increased mast cell infiltration …”

supporting

confidence: 90%

“…We previously reported a case of Morbihan disease with massive mast cell infiltration treated successfully with long‐term use of minocycline (100 mg/day for 4 months), in which we hypothesized that the treatment response was associated with the degree of mast cell infiltration . Although increased mast cell infiltration is one of the histological features, it is not found in all cases .…”

mentioning

confidence: 99%

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Successful treatment with long‐term use of minocycline for Morbihan disease showing mast cell infiltration: A second case report

Kabuto

Fujimoto

Honda

et al. 2015

The Journal of Dermatology

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supporting

confidence: 90%

mentioning

confidence: 99%

Successful treatment with long‐term use of minocycline for Morbihan disease showing mast cell infiltration: A second case report

Kabuto

Fujimoto

Honda

et al. 2015

The Journal of Dermatology

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“…Mast cell infiltration is another common histological feature, which was also observed in our case. Fujimoto et al stated that this finding may be associated with the disease stage and biopsy technique (Fujimoto, Mitsuru, & Tanaka, ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of long-term intralesional triamcinolone in Morbihan's disease and its possible association with mast cell infiltration

Tsiogka

Koller

2018

Dermatologic Therapy

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Morbihan's disease is characterized by chronic persistent facial edema of the upper half of the face, absence of typical diagnostic findings, and refractoriness to treatment. A 44‐year‐old man was diagnosed with Morbihan's disease based on clinical signs and histopathology, which showed dermal edema in upper dermis, discrete lymphocytic infiltrate without granulomatous reaction, and mast cell infiltration. After long‐term therapy with intralesional triamcinolone a remarkable objective and subjective clinical response was observed. Reported cases of Morbihan's disease are reviewed, with respect to their treatment and histopathological findings. Mast cell infiltration has been observed on histopathology in most patients who responded to intralesional triamcinolone, suggesting a possible marker of response. The long‐lasting response seen in our case indicates the efficacy of intralesional triamcinolone in this rare condition.

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“…There is no guideline for its management. However, reported therapy includes long-term systemic corticosteroids and/or oral antibiotics such as doxycycline and isotretinoin [24]. …”

Section: Resultsmentioning

confidence: 99%

How Not to Be Misled by Disorders Mimicking Angioedema: A Review of Pseudoangioedema

Andersen¹,

Longhurst

Rasmussen

et al. 2016

Int Arch Allergy Immunol

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Background: Angioedema is a vascular reaction involving the lower dermis, subcutis and/or submucosal tissue and causing a temporary localized swelling in any part of the body. For many health care professionals, the diagnosis presents an ongoing challenge; several disorders may manifest with subcutaneous or submucosal swelling and falsely be assumed to be angioedema. The clinicians at the emergency department and in the immunology/allergy clinics must be skilled at recognizing the features of angioedema and its differential diagnosis. Methods: The review is based on a literature search with specific indexing terms in PubMed, a review of bibliographies and the authors' clinical experience. Results: The most essential diseases that mimic angioedema, the so-called pseudoangioedemas, will each be discussed and illustrated by clinical photos, pointing out key features that help clarify the diagnoses and differentiate these from classic angioedema. Conclusions: A variety of dermatologic conditions can cause swelling that resembles angioedema, some with a potentially fatal outcome if misdiagnosed. Knowledge of pseudoangioedema is fundamental in the emergency setting when handling patients with edema and should be kept in mind when assessing an atypical angioedema case.

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Successful Treatment of Morbihan Disease with Long-term Minocycline and its Association with Mast Cell Infiltration

Cited by 25 publications

References 12 publications

Successful treatment with long‐term use of minocycline for Morbihan disease showing mast cell infiltration: A second case report

Successful treatment with long‐term use of minocycline for Morbihan disease showing mast cell infiltration: A second case report

Efficacy of long-term intralesional triamcinolone in Morbihan's disease and its possible association with mast cell infiltration

How Not to Be Misled by Disorders Mimicking Angioedema: A Review of Pseudoangioedema

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