Mononuclear indolyldithiocarbamates of SnCl4 and R2SnCl2: Spectroscopic, thermal characterizations and cytotoxicity assays in vitro

Khan, Shabnam; Nami, Shahab A.A.; Siddiqi, K. S.

doi:10.1016/j.jorganchem.2007.12.026

Cited by 39 publications

(14 citation statements)

References 45 publications

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“…Even though for each complex with the same coordination number, some wide range of δ ( 119 Sn) values ore observed depending on the different organic and dithiocarboxylate groups attached to the Sn atom, there is an approximate linear relationship between the 119 Sn values and the coordination number of the complexes. According to Holecek and coworkers, for the range of +200 to −60, −90 to −190, −210 to −400, −440 to −540 ppm, the coordinate number of the tin is four, five, six and seven, respectively . The appearance of a single peak in the 119 Sn NMR spectra of all the studied complexes signified the formation of single species .…”

Section: Resultsmentioning

confidence: 85%

New mononuclear diorganotin(IV) dithiocarboxylates: synthesis, characterization and study of their cytotoxic activities

Yousefi

Safari

Torbati

et al. 2012

Applied Organom Chemis

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Since organotin complexes have been reported to show fewer side effects relative to other heavy metal anticancer compounds, in the present study we report for the first time four novel organotin(IV) derivatives with the general formula R 2 SnL 2 , where R = methyl (1), n-butyl (2), phenyl (3), benzyl (4) and L = morpholine-1-carbodithioate (MCDT). The newly synthesized ligand was monodentate or bidentate, coordinating through a sulfur atom. The complexes were synthesized by directly mixing, refluxing and stirring the ligand, with diorganotin(IV) dichlorides in a suitable solvent. The complexes were found to be pure and their solid and solution phase structural configuration was investigated by FT-IR, multinuclear NMR ( 1 H, 13 C, 119 Sn) and mass spectrometry. Complex 2 was also studied for its thermal decomposition by thermogravimetry and differential thermal analysis. The results obtained on the basis of these techniques are in full concurrence with the proposed 1:2 (Sn:L) stoichiometry. The cytotoxic activity of the MCDT and diorganotin(IV) complexes (1-4) was tested against tumor cell lineshuman cervix carcinoma HeLa and human myelogenous leukemia K562and normal immunocompetent cells: peripheral blood mononuclear cells PBMC. Results of bioassay demonstrated that organotin derivatives were in general more active than the anticancer drug cisplatin.

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Section: Resultsmentioning

confidence: 85%

New mononuclear diorganotin(IV) dithiocarboxylates: synthesis, characterization and study of their cytotoxic activities

Yousefi

Safari

Torbati

et al. 2012

Applied Organom Chemis

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“…Their complexes are finding newer applications in many areas of chemistry, biology and industry [4]. For instance, (CH3)2NCSS¯ is used for the separation of various metal ions as their metal chelates [5] while its As-Complex / Sn-complex found to possess strong anti-cancer properties [6]. Metal complexes with potentially tridentate and tetradentate ligands have evoked much interest in coordination chemistry [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Spectral Studies and Antimicrobial Study on Mixed Ligand Complexes of Chloro-arsenic(III) Derived from β-Ketiminates & Piperidine Dithiocarbamate Ligand Moity

Sharma¹,

Sharma²,

Sharma³

2019

AJOCS

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A series of Chloro-arsenic(III) complexes with N, O donor β-ketiminate ligand (L 1 ) and S, S donor piperidine dithiocarbamate ligand (L 2 ) have been synthesized by the reactions of AsCl 3 with both ligands in equimolar ratio by stirring at room temperature in benzene solution. All these synthesized compounds have been characterized by Elemental Analysis, IR, ( 1 H and 13 C) NMR Spectral and ESI-Mass Studies. Both Ligands and their corresponding Chloro-arsenic (III) complexes have been screened for antimicrobial activity against the various bacterial (E. coli, B. subtalis and P. aeruginosa) and fungal (T. resei, P. funiculosum and Fusarium) strains and results obtained.

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“…This bond plays one of the major roles in the activity of the whole compound [3]. Organotin derivatives have gotten a lot of attention in the previous decades due to its numerous biological activities ranging from antibacterial and antifungal properties [4][5][6][7][8] to antiproliferative and anticancer properties [9][10][11][12][13][14] as well as larvicidal properties [15]. Most organotin(IV) compounds are found to be very toxic, even at low concentrations [1].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Novel Diorganotin(IV) Complexes Derived from N-Methyl-phenethyl Dithiocarbamate and Bis(2-ethoxyethyl) Dithiocarbamate

Pim

Awang²,

Mohamad

et al. 2018

Asian J. Chem.

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Mononuclear indolyldithiocarbamates of SnCl4 and R2SnCl2: Spectroscopic, thermal characterizations and cytotoxicity assays in vitro

Cited by 39 publications

References 45 publications

New mononuclear diorganotin(IV) dithiocarboxylates: synthesis, characterization and study of their cytotoxic activities

New mononuclear diorganotin(IV) dithiocarboxylates: synthesis, characterization and study of their cytotoxic activities

Synthesis, Characterization, Spectral Studies and Antimicrobial Study on Mixed Ligand Complexes of Chloro-arsenic(III) Derived from β-Ketiminates & Piperidine Dithiocarbamate Ligand Moity

Synthesis and Characterization of Novel Diorganotin(IV) Complexes Derived from N-Methyl-phenethyl Dithiocarbamate and Bis(2-ethoxyethyl) Dithiocarbamate

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