Monocyte to High-Density Lipoprotein Ratio Predicts Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome

Abstract

Contrast-induced nephropathy (CIN) is associated with worse prognosis in patients with acute coronary syndrome (ACS). Early identification and intervention for patients with a high risk of CIN are very important to improve clinical outcomes. Inflammation plays important role in the development of CIN in the setting of ACS. The monocyte to high-density lipoprotein ratio (MHR) is a novel inflammatory marker. Bleeding is also associated with worse prognosis in such patients. We aimed to investigate whether the preprocedural MHR had a predictive role for CIN development in such patients. In addition, using the thrombolysis in myocardial infarction classification, we aimed to assess whether there was any relationship between bleeding and CIN. A total of 647 patients (496 males; age: 63.3 ± 12.7 years) with ACS who underwent percutaneous coronary intervention (PCI) were included in the study. Seventy patients (10.8%) had developed CIN. Age, diabetes mellitus, contrast volume, estimated glomerular filtration rate, and MHR were independent predictors for CIN. Preprocedural MHR may be used as a simple marker of CIN. It may help with the early identification of patients with ACS who underwent PCI who are at high risk of CIN thus allowing the planning of protective measures.

Comparing the Prognostic Value of Hematological Indices in Patients With ST Segment Elevation Myocardial Infarction: “A Head to Head” Analysis

“…Each marker, on its own, has been shown to be associated with in-hospital and/or long-term mortality (LTM) in patients with STEMI. 9 –14 Although some reviews and meta-analyses focused on their effects on the prognosis in patients with CAD, little is known about their comparative predictive value. Therefore, in this study, we aimed to investigate which hematological indices have the most discriminatory capability for prediction of in-hospital and LTM in a large STEMI cohort.…”

Serum Osmolarity and Contrast-Induced Nephropathy

“…10 Many available biomarkers such as homocysteine, procalcitonin, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, red cell distribution width, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, monocyte to highdensity lipoprotein ratio, and fibrinogen to albumin ratio (FAR) have been shown to predict CIN development. [11][12][13][14][15][16][17][18][19] In the study by Yildiz et al, 1 serum osmolarity, hemoglobin, contrast media volume, creatinine on admission, basal SYNergy between PCI with TAXus and cardiac surgery II score, and left ventricular ejection fraction were found to be independent predictors of CIN. However, serum osmolarity only had a modest predictive accuracy for CIN in this analysis.…”

“…10 Many available biomarkers such as homocysteine, procalcitonin, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, red cell distribution width, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, monocyte to high-density lipoprotein ratio, and fibrinogen to albumin ratio (FAR) have been shown to predict CIN development. 11 –19…”

Comparison Of Monocyte / HDL Ratio In Routine Hemodialysis And Peritoneal Dialysis Patients

“…The clinical trials conducted in recent years have shown that monocyte/HDL ratio (MHR) might be a new marker of inflammation 10,11 . Previous studies that claimed that, MHR may be related with the risk of contrast nephropathy development and monocyte and HDL cholesterol levels of patients with CKD may be used to predict their cardiovascular events 12,13 . This cross-sectional study aims to compare MHR levels of patients who have HD and PD as renal replacement therapy.…”