Monocryl® suture, a new ultra-pliable absorbable monofilament suture

Bezwada, Rao S.; Jamiolkowski, Dennis D.; Lee, In-Young; Agarwal, Vishvaroop; Persivale, Joseph; Trenka-Benthin, Susan; Erneta, Modesto; Suryadevara, Jogendra; Yang, Alan Hao; Liu, Sylvia

doi:10.1016/0142-9612(95)93577-z

Cited by 364 publications

(262 citation statements)

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“…The 7 th postoperative day was chosen because it is around this period of time that occur most enterocutaneous fistulas. In 14 days high collagen rates happen almost similar to the ones in pre-operative period, and also in this period all complications that might exist, occur 10,13,14,15,17,21,33 .…”

Section: Discussionmentioning

confidence: 74%

“…It is animal in origin, characterized by large inflammatory response during absorption, which is highly Poliglecaprone 25 is a synthetic, absorbable monofilament which is proposed to have lower absorption time 10,13,17,18,21,24,[28][29][30][31][32] .…”

Section: Discussionmentioning

confidence: 99%

“…They had the advantages of predictable absorption time with a mild inflammatory reaction. Afterwards, was produced a monofilament poliglecaprone 25 with advantages of absorption time be predictable and relatively short [13][14][15][16][17][18][19][20] . Other absorbable monofilament threads, as polydioxanone and poligliconate, require medium or long time for its absorption 12,21,22 .…”

Section: Introductionmentioning

confidence: 99%

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Cecorraphy in single layer using polypropylene and poliglecaprone 25 threads: comparative study in rats

Tabushi¹,

Nomura²,

Malafaia

et al. 2012

Acta Cir. Bras.

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PURPOSE:To compare sutures with polypropylene and poliglecaprone 25 after partial cecotomy in rats. METHODS:Thirty six rats divided into two groups, A and B, of 18 animals; each group was also divided into three subgroups of six animals sacrificed at 4 th , 7 th and 14 th days after surgery. Were studied the mortality, morbidity, complications attributable to sutures, macroscopy, optical microscopy and measurement of hydroxyproline at the level of the suture. RESULTS:There were no deaths or wound complications such as hematoma, seroma, abscess, evisceration or eventration. On microscopic evaluation reepithelization, coaptation and inflammation in both groups did not differ significantly. The average rate of tissue hydroxyproline found in the samples on the 4 th day after surgery, was 21.38 mg/g tissue for group A and 16.68 mg/g for group B; on day 7 after surgery, the average was 15.64 mg/g tissue for group A and 26.53 mg/g for group B; on day 14, the average was 8.09 mg/g tissue for group A and 25.07 mg/g for group B.CONCLUSION: There were no differences on clinical evolution, macroscopic aspect, microscopic data and hydroxyproline concentration on both sutures.Key words: Suture Techniques. Anastomosis, Surgical. Cecum. Polypropylenes. Rats. RESUMO OBJETIVO:Comparar a sutura com fio de polipropileno e poliglecaprone 25 após cecotomia parcial em ratos. MÉTODOS:Trinta e seis ratos foram distribuídos em dois grupos A e B de 18 animais, e cada grupo foi dividido em três subgrupos de seis, sacrificados no 4º, 7º e 14º dias do pós-operatório. Estudou-se a mortalidade, morbidade, complicações atribuíveis às suturas, macroscopia, microscopia ótica e dosagem de hidroxiprolina no nível da sutura. RESULTADOS:Não houve mortalidade ou complicações da ferida operatória como hematoma, seroma, abscesso, evisceração ou eventração.Na avaliação microscópica os critérios de re-epitelização, coaptação e processo inflamatório ambos os grupos não apresentaram diferença significativa. A taxa tecidual média da hidroxiprolina encontrada nas amostras no 4º dia de pós-operatório foi de 21,38 mg/g de tecido para o grupo A e 16,68 mg/g para o grupo B; no 7º dia a média foi de 15,64 mg/g de tecido para o grupo A e 26,53 mg/g para o grupo B; no 14º dia ela foi de 8,09 mg/g de tecido para o grupo A e 25,07 mg/g para o grupo B.CONCLUSÃO: Não houve diferença estatística entre a evolução clínica, avaliação macroscópica, microscopia e dosagem de hidroxiprolina entre as suturas realizadas com os fios estudados.Descritores: Técnicas de Sutura. Anastomose Cirúrgica. Ceco. Polipropilenos. Ratos.Tabushi FI et al.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cecorraphy in single layer using polypropylene and poliglecaprone 25 threads: comparative study in rats

Tabushi¹,

Nomura²,

Malafaia

et al. 2012

Acta Cir. Bras.

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“…It degrades through hydrolytic scission and has resistance to rapid hydrolysis. Because of its biocompatibility properties, degradation rate and mechanical strength, it has been investigated as a biomaterial for medical drug delivery devices (20)(21)(22)(23)(24)(25), and load-bearing bone tissue engineering applications (26,27). PCL is characterized by a resorption time slower than other polyesters (28,29), and a negligible weight loss (below 2% in 30 days) (30,31).…”

Section: Introductionmentioning

confidence: 99%

Porous alginate/poly(ε-caprolactone) scaffolds: preparation, characterization and in vitro biological activity

Grandi

Liddo

Paganin³

et al. 2011

Int J Mol Med

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Abstract. In bone tissue engineering, scaffolds with controlled porosity are required to allow cell ingrowth, nutrient diffusion and sufficient formation of vascular networks. The physical properties of synthetic scaffolds are known to be dependent on the biomaterial type and its processing technique. In this study, we demonstrate that the separation phase technique is a useful method to process poly(Â-caprolactone) (PCL) into a desired shape and size. Moreover, using poly(ethylene glycol), sucrose, fructose and Ca 2+ alginate as porogen agents, we obtained PCL scaffolds with three-dimensional porous structures characterized by different pore size and geometry. Scanning electron microscopy and porosity analysis indicated that PCL scaffolds prepared with Ca 2+ alginate threads resemble the porosity and the homogeneous pore size distribution of native bone. In parallel, MicroCT analysis confirmed the presence of interconnected void spaces suitable to guarantee a biological environment for cellular growth, as demonstrated by a biocompatibility test with MC3T3-E1 murine preosteoblastic cells. In particular, scaffolds prepared with Ca 2+ alginate threads increased adhesion and proliferation of MC3T3-E1 cells under basal culture conditions, and upon stimulation with a specific differentiation culture medium they enhanced the early and later differentiated cell functions, including alkaline phosphatase activity and mineralized extracellular matrix production. These results suggest that PCL scaffolds, obtained by separation phase technique and prepared with alginate threads, could be considered as candidates for bone tissue engineering applications, possessing the required physical and biological properties.

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“…The biodegradability of this compound is based on the susceptibility of its aliphatic ester linkage to hydrolysis and its products of degradation are either metabolised by being included in the tricarboxylic acid cycle or eliminated by renal secretion (Kweon et al, 2003). This polymer has been used in several medical applications already approved by the US Food and Drug Administration (Bezwada et al, 1995;Darney et al, 1989). Nowadays, PCL is being applied not only in the development of drug delivery systems (Giavaresi et al, 2004), and resorbable sutures (Tomihata et al, 1998), but also as a material for tissue regeneration (Sarasam and Madihally, 2005).…”

Section: Introductionmentioning

confidence: 99%

Development of a new photocrosslinkable biodegradable bioadhesive

Ferreira

Coelho

Gil

2008

International Journal of Pharmaceutics

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Adhesives provide a needle-free method of wound closure and do not require local anaesthetics. Polymeric adhesives have been used for about 3 decades for joining several tissues of the organism. Also, they can accomplish other tasks, such as haemostasis and the ability to seal air leakages and have the potential to serve as delivery systems.PCL was modified with 2-isocyanatoethylmethacrylate to form a macromer that was crosslinked via UV irradiation using Irgacure 2959 by CIBA ® as the photoinitiating agent. The characterization of the materials was accomplished by: attenuated total reflectance-Fourier transform infrared (ATR-FTIR), swelling capacity determination, evaluation of adhesive capacity (by reaction with aminated substrates) and determination of surface energy by contact angle measurement. Thermal characterization of the adhesive was performed by dynamical mechanical thermal analysis (DMTA) and thermogravimetric analysis (TGA). The morphology of PCL networks was observed using scanning electron microscopy (SEM) both after crosslinking process and following biodegradation in human plasma.The haemocompatibility of the membranes was also evaluated by thrombosis and haemolysis tests.

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Monocryl® suture, a new ultra-pliable absorbable monofilament suture

Cited by 364 publications

References 1 publication

Cecorraphy in single layer using polypropylene and poliglecaprone 25 threads: comparative study in rats

Cecorraphy in single layer using polypropylene and poliglecaprone 25 threads: comparative study in rats

Porous alginate/poly(ε-caprolactone) scaffolds: preparation, characterization and in vitro biological activity

Development of a new photocrosslinkable biodegradable bioadhesive

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