Monoamine levels after pilocarpine-induced status epilepticus in hippocampus and frontal cortex of Wistar rats

Freitas, Rivelilson Mendes de; Vasconcelos, Silvânia Maria Mendes; Souza, Francisca C. F.; Viana, Glauce Socorro Barros; Fonteles, M.M.F.

doi:10.1016/j.neulet.2004.08.024

Cited by 28 publications

(13 citation statements)

References 28 publications

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“…The results of the present study showed that the levels of neurotransmitters DA, DOPAC and 5-HT were depleted significantly by Cd treatment in the forebrain (cerebral part containing hippocampus and striatum) tissue of the Cd-exposed mice. There is evidence of an inhibitory role of DA mediated receptor (D 2 type) in depressing the hyperexcitability of hippocampal and striatal neurons [56,57]. A number of 5-HT receptor subtypes have been reported for having different roles in the functions of serotonergic neurotransmission, including the functions connected with learning and memory processes [58].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Curcumin on Anxiety, Learning Behavior, Neuromuscular Activities, Brain Neurotransmitters and Oxidative Stress Enzymes in Cadmium Intoxicated Mice

Abu-Taweel¹,

Ajarem²,

Ahmad

2013

JBBS

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Cadmium (Cd) exposure can induce acute lethal health-related threats to humans since it has an exceptional ability to accumulate in living organisms and cause toxicological effects. Curcumin (Cur) on the other hand has a wide variety of biological activities and several animal studies have suggested for a potential therapeutic or preventive effects against several ailments and infections. To study the effect of Cur on the toxicity of Cd, sixty Swiss-Webster strain male mice were divided into 6 groups of ten each at random. Group-1 served as the na?ve control and received no treatment. Group-2, 3 and 4 were the experimental controls and were administered once a day with a single oral dose of 50% dimethyl sulphoxide (DMSO), Cur (300 mg/kg) or Cd (100 mg/kg) respectively, for 2 weeks. Group-5 and 6 received Cur and Cd in combination once a day orally for 2 weeks except that Cur in a dose of 150 and 300 mg/kg to group 5 and 6 respectively, was administered one hour before Cd (100 mg/kg) administration to both groups. After treatment period, the animals were subjected to behavioral tests and thereafter, the animals were sacrificed for the estimation of neurotransmitters like serotonin (5-HT), dopamine (DA) and it’s metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) as well as oxidative stress enzymes like lipid peroxides in the form of thiobarbituric acid–reactive substances (TBARS) and total glutathione (GSH) in the forebrain tissue. Cd reduced significantly the body weight gain, the locomotor activity, anxiety behavior in the plus maze and the learning capability (cognitive effect) in the shuttle-box test. Biochemical analysis further revealed that Cd exposure significantly altered the brain neurotransmitters and the oxidative stress enzymes. However, administration of Cur along with Cd had an ameliorating effect on all the behavioral and biochemical parameters studied herein and reduced the toxicity of Cd significantly and dose-dependently. Thus, Cur may be beneficial for anxiety, neuromuscular, and cognitive problems and protect from Cd intoxication.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Curcumin on Anxiety, Learning Behavior, Neuromuscular Activities, Brain Neurotransmitters and Oxidative Stress Enzymes in Cadmium Intoxicated Mice

Abu-Taweel¹,

Ajarem²,

Ahmad

2013

JBBS

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“…Extensive toxicological and biochemical experiments have been performed to explain the central nervous system (CNS) effects observed under therapeutic conditions (Akahane et al, 1993;De Sarro et al, 1999;De Sarro and De Sarro, 2001). Seizure activity is associated with a wide range of local biochemical changes, affecting various neurotransmitters (monoamines, amino acids) (Freitas et al, 2004;Cavalheiro et al, 2006). Green and Halliwell (1997) contributed the excitatory action of ciprofloxacin to its selective antagonistic effect on GABA (A) receptors and proconvulsion activity (Dodd et al, 1988;Kawakami et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective role of Nigella sativa extract on ciprofloxacin and pentylenetetrazole treated rats

Abdel-Rahman¹

2013

Afr. J. Pharm. Pharmacol.

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This study aimed to investigate the Nigella sativa seed (NS) neuroprotective effect on ciprofloxacin (CFX) antibiotic with suggesting neurotoxic effect in rats through the determination of monoamines levels and acetylcholinesterase (AChE) activity in different brain areas. We used valporic acid as a reference antiepileptic drug and pentylenetetrazole (PTZ), a drug used for induction of epileptic model in rats. The present data revealed that the daily oral administration of NS (350 mg/kg b.wt.) for 14 days caused significant increase in the monoamines contents with no statistical difference in AChE as compare to control values. While the administration of CFX (500 mg/kg b.wt.) and/or PTZ (60 mg/kg b.wt.) was found to produce significant decrease in the concentration of monoamines and the activity of AChE in cerebral cortex, cerebellum, striatum and hippocampus after 7 and 14 days. Moreover, the preand post-treatment with NS in CFX and/or PTZ treated rats was found to ameliorate most of the side effects induced by these drugs. It could be concluded that the treatment with the therapeutic dose of CFX 14 days could lead to the development of seizures through the reduction of monoamines level and decreasing the activity of AChE in the tested brain areas. The administration of N. sativa pre-and the post treatment to CFX and/or PTZ treated rats were found to ameliorate their side effects. Suggesting that N. sativa seeds with antiepileptic activity and its administration could alleviate ciprofloxacin neurotoxicity.

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“…Other researches suggest permanent changes in the concentration of the brain neurotransmitters during seizures and status epilepticus (SE) induced by pilocarpine 4-9 . An increase in dopamine level, a decrease in serotonin (5-HT) content, and also an excessive increase in concentration of 3,4-hydroxyphenylacetic acid (DOPAC) may occur in hippocampus and frontal cortex of adult rats during SE induced by pilocarpine 10 .…”

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confidence: 99%

Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures

Santos

Campêlo

Freitas³

et al. 2011

Arq. Neuro-Psiquiatr.

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Pilocarpine-induced seizures can be mediated by increases in oxidative stress and by cerebral amino acid changes. The present research suggests that antioxidant compounds may afford some level of neuroprotection against the neurotoxicity of seizures in cellular level. The objective of the present study was to evaluate the lipoic acid (LA) effects in glutamate and taurine contents in rat hippocampus after pilocarpine-induced seizures. Wistar rats were treated intraperitoneally (i.p.) with 0.9% saline (Control), pilocarpine (400 mg/kg, Pilocarpine), LA (10 mg/kg, LA), and the association of LA (10 mg/kg) plus pilocarpine (400 mg/kg), that was injected 30 min before of administration of LA (LA plus pilocarpine). Animals were observed during 24 h. The amino acid concentrations were measured using high-performance liquid chromatograph (HPLC). In pilocarpine group, it was observed a significant increase in glutamate content (37%) and a decrease in taurine level (18%) in rat hippocampus, when compared to control group. Antioxidant pretreatment significantly reduced the glutamate level (28%) and augmented taurine content (32%) in rat hippocampus, when compared to pilocarpine group. Our findings strongly support amino acid changes in hippocampus during seizures induced by pilocarpine, and suggest that glutamate-induced brain damage plays a crucial role in pathogenic consequences of seizures, and imply that strong protective effect could be achieved using lipoic acid through the release or decrease in metabolization rate of taurine amino acid during seizures. Key words: seizures, pilocarpine, amino acids, hippocampus, glutamate, taurine.Efeitos do ácido lipóico nas concentrações de glutamato e taurina no hipocampo de ratos após convulsões induzidas por pilocarpina RESUMO As convulsões induzidas pela pilocarpina podem ser mediadas através do aumento do estresse oxidativo cerebral e das alterações na concentração dos aminoácidos. O presente estudo sugere que compostos antioxidantes podem produzir neuroproteção contra a neurotoxicidade em nível celular causada pelas convulsões. O objetivo deste estudo foi avaliar os efeitos do ácido lipóico (AL) no conteúdo de glutamato e taurina no hipocampo de ratos durante convulsões induzidas por pilocarpina. Ratos Wistar foram tratados por via intraperitoneal com solução salina 0,9% (controle), pilocarpina (400 mg/kg, pilocarpina), AL (10 mg/kg) e com a associação de AL (10 mg/kg); 30 min após com pilocarpina (400 mg/kg), que foi injetada 30 min após a administração de AL (AL + pilocarpina). Os animais foram observados durante 24 horas. As concentrações de aminoácidos foram

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Monoamine levels after pilocarpine-induced status epilepticus in hippocampus and frontal cortex of Wistar rats

Cited by 28 publications

References 28 publications

Protective Effect of Curcumin on Anxiety, Learning Behavior, Neuromuscular Activities, Brain Neurotransmitters and Oxidative Stress Enzymes in Cadmium Intoxicated Mice

Protective Effect of Curcumin on Anxiety, Learning Behavior, Neuromuscular Activities, Brain Neurotransmitters and Oxidative Stress Enzymes in Cadmium Intoxicated Mice

The neuroprotective role of Nigella sativa extract on ciprofloxacin and pentylenetetrazole treated rats

Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures

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