Monitoring Coagulation Proteins During Progression of Liver Disease

Hessien, Mohamed; Ayad, Mohamad M.; Ibrahim, Wafaa; ulArab, Batoul Izz

doi:10.1007/s12291-014-0429-1

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…Therefore, patients with cirrhosis and compromised liver function may generally have less plasma fibrinogen levels than healthy counterparts. 25 , 29 However, our WMD analyses showed that the pretreatment plasma fibrinogen levels in HCC cases were not significantly elevated when compared with that in healthy subjects (WMD = 0.50, 95% CI = [−0.82, 1.82], P = 0.457) or patients with cirrhosis (WMD = −0.62, 95% CI = [−1.56, 0.33], P = 0.200). Therefore, plasma fibrinogen level is not usable as a diagnostic marker for HCC detection.…”

Section: Discussionmentioning

confidence: 73%

“…In this meta-analysis, we identified eight studies 20 – 23 , 25 , 29 – 31 that examined the pretreatment plasma fibrinogen levels in HCC, cirrhotic, and/or healthy subjects. We observed that patients with cirrhosis had significantly lower plasma fibrinogen levels compared to healthy controls (WMD = −0.44, 95% CI = [−0.86, −0.01], P = 0.043).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies reported that HCC patients showed higher levels of pretreatment plasma fibrinogen compared to healthy controls or cirrhotic patients. 20 – 22 However, Basili et al 23 and Liu et al 24 found no significant difference in the plasma fibrinogen levels between HCC and control or cirrhotic groups, and Hessien et al 25 indicated lower levels of fibrinogen in HCC patients compared to that in control and cirrhotic patients. Therefore, our present study aims to summarize the currently available studies to examine 1) whether the pretreatment plasma fibrinogen levels were significantly different among HCC, cirrhotic, and healthy subjects; 2) the association between elevated plasma fibrinogen and prognosis in patients with HCC; and 3) the association between elevated fibrinogen levels and tumor progression in patients with HCC.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Huang¹,

Jiang²,

Lin³

et al. 2018

CMAR

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BackgroundElevated plasma fibrinogen levels have been associated with tumor progression in several malignancies. Our study aims to characterize the clinical significance of elevated plasma fibrinogen levels in patients with hepatocellular carcinoma (HCC).Materials and methodsRelevant published articles were systematically searched in electronic databases including PubMed, Embase, and Web of Science. The pooled differences in plasma fibrinogen levels among HCC, cirrhotic, and control groups were expressed as weighted mean differences (WMDs) and their corresponding 95% CIs. The associations between elevated fibrinogen and overall survival (OS) and disease-free survival (DFS)/recurrence-free survival (RFS) were expressed as HRs and their 95% CIs, whereas the associations between elevated fibrinogen and various types of clinical characteristic of patients with HCC were expressed as ORs and their corresponding 95% CIs.ResultsResults showed that the plasma fibrinogen levels in patients with HCC were not significantly different than that in healthy controls (WMD = 0.50, 95% CI = [−0.82, 1.82], P = 0.457) or patients with cirrhosis (WMD = −0.62, 95% CI = [−1.56, 0.33], P = 0.200). However, our results showed that compared to those with normal levels, patients with HCC and elevated plasma fibrinogen levels showed poorer OS (HR = 2.08, 95% CI = [1.67, 2.59], P < 0.0001) and DFS/RFS (HR = 1.90, 95% CI = [1.52, 2.37], P < 0.0001). Results of trial sequential analysis of the OS indicated that currently available studies were sufficient to validate the negative prognostic value of elevated plasma fibrinogen in patients with HCC. Clinicopathological analyses showed that high plasma fibrinogen levels were associated with tumor progression as indicated by advanced tumor stage, larger tumor size, increased tumor number, and the presence of vascular invasion.ConclusionElevated plasma fibrinogen levels are associated with poor prognosis and advanced tumor progression. Plasma fibrinogen may serve as a negative prognostic biomarker in patients with HCC.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Huang¹,

Jiang²,

Lin³

et al. 2018

CMAR

View full text Add to dashboard Cite

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“…< 37 U/mL ≥ 37 U/mL hemostatic proteins and protein inhibitor complexes from the circulation, so that patients can experience severe bleeding or even thrombotic complications ( 14,15). However, few researchers analyzed coagulopathy in ICC patients.…”

Section: Discussionmentioning

confidence: 99%

Coagulopathy associated with poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection

Wang

Liu

Tian

et al. 2017

BST

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“…71 Reduced fibrinogen levels can be a result of either reduced synthesis, increased destruction, or a combination of these two. 72 The elevated levels of FDPs in cirrhotic patients demonstrate the accelerated fibrinogen consumption and/or decreased hepatic clearance rate of FDPs. The FDPs contribute to the prolongation of PT by intervening with fibrin polymerization.…”

Section: Fibrinogenmentioning

confidence: 99%

A Review on Clinical, Pathophysiological, and Diagnostic Hematological Features in Children With Liver Cirrhosis

Shahramian

Tabrizian

Delaramnasab

et al. 2019

Int J Basic Sci Med

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Appropriate diagnostic and therapeutic measures for liver cirrhosis is critical, particularly in children. In the present review, a comprehensive approach was provided toward hematological parameters in pediatric liver cirrhosis. The literature search included MeSH terms "liver cirrhosis" and "hepatic cirrhosis" and databases such as PubMed, Web of Science, Scopus, and Google Scholar were searched up until December 2017. Hematologic changes in the liver cirrhosis mainly encompassed anemia and coagulopathies. In addition, bleeding diathesis was considered as the most clinical complication in these patients. In addition to reduced coagulation factors, hyperfibrinolysis is a common feature in childhood cirrhosis and may be an important contributor to the risk of bleeding. Based on the results, children with liver cirrhosis also demonstrated a procoagulant state at laboratory and clinical levels. This may be partly due to a reduction in coagulation inhibitors such as anti-thrombin, C1 inhibitor, and α1-antitrypsin in children with cirrhosis. The portal vein thrombosis and portal hypertension are considered as the most clinical presentations of the hypercoagulable state. Further, children with liver cirrhosis complicated with portal hypertension usually show leukopenia, anemia, and thrombocytopenia due to hypersplenism. Although the etiology of childhood and adult cirrhosis may be different, their hematological compilations and clinicopathological features are somehow similar.

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Monitoring Coagulation Proteins During Progression of Liver Disease

Cited by 8 publications

References 32 publications

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Coagulopathy associated with poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection

A Review on Clinical, Pathophysiological, and Diagnostic Hematological Features in Children With Liver Cirrhosis

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