Coagulopathy associated with poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection

Wang, Han; Liu, Weiren; Tian, Min; Tang, Zheng; Jiang, Xi‐Fei; Zhou, Pei‐Yun; Ding, Zhen–Bin; Peng, Yuan‐Fei; Dai, Zhi; Qiu, Shuang–Jian; Zhou, Ji; Fan, Jia; Shi, Ying‐Hong

doi:10.5582/bst.2017.01080

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…Previously, Wang et al showed that a prolonged PT was related to a high recurrence rate and poor prognosis for patients with ICC following curative resection [29]. A retrospective and in vitro study with a relatively small sample size (n = 115) conducted by Shu et al showed the clinical significance of elevated preoperative FBG in GBC patients after surgical resection [24].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of coagulation indices for predicting survival in patients with biliary tract cancer

Bao

You

et al. 2021

BMC Cancer

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Background Abnormal activation of the coagulation system has been reported in patients with malignancies, but its prognostic significance in biliary tract cancer (BTC) remains unclear. This study aims to analyze and compare the prognostic value of coagulation indices in patients with BTC. Methods The medical records of 450 patients with BTC who underwent surgical resection at our hospital between 2003 and 2017 were retrospectively analyzed. Time-dependent receiver operating characteristic curves were plotted to compare the predictive accuracy of coagulation indices. A predictive nomogram for overall survival (OS) was established based on the Cox regression analysis and validated in both the training and validation cohorts. A novel stratification model was created according to the total points of the nomogram. Results Fibrinogen and international normalized ratio (INR) had the best predictive accuracy among the coagulation indices considered and were also the independent prognostic factors for OS. The nomogram and the novel stratification model had satisfactory performance and outperformed TNM staging. Conclusions The study demonstrated that coagulation indices are valuable in predicting OS in BTC, with fibrinogen and INR having the best predictive ability. The nomogram and the novel stratification model could be applied to predict survival for patients with BTC.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of coagulation indices for predicting survival in patients with biliary tract cancer

Bao

You

et al. 2021

BMC Cancer

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“…It exhibits high heterogeneity, malignancy, and complexity in signaling pathways, leading to poor prognosis and a propensity for metastasis [ 1 , 2 ]. Due to the inconspicuous early symptoms, lack of specific molecular markers, and suitable early diagnostic methods, the majority of CCA patients are diagnosed at advanced stages, resulting in a less than 10% 5-year survival rate [ 3 , 4 ]. Consequently, there is an urgent need for new biomarkers and therapeutic targets to enhance early detection and patient prognosis.…”

Section: Introductionmentioning

confidence: 99%

Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells

Zhou,

Kong,

et al. 2024

J Nanobiotechnol

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Background Exosomes assume a pivotal role as essential mediators of intercellular communication within tumor microenvironments. Within this context, long noncoding RNAs (LncRNAs) have been observed to be preferentially sorted into exosomes, thus exerting regulatory control over the initiation and progression of cancer through diverse mechanisms. Results Exosomes were successfully isolated from cholangiocarcinoma (CCA) CTCs organoid and healthy human serum. Notably, the LncRNA titin-antisense RNA1 (TTN-AS1) exhibited a conspicuous up-regulation within CCA CTCs organoid derived exosomes. Furthermore, a significant elevation of TTN-AS1 expression was observed in tumor tissues, as well as in blood and serum exosomes from patients afflicted with CCA. Importantly, this hightened TTN-AS1 expression in serum exosomes of CCA patients manifested a strong correlation with both lymph node metastasis and TNM staging. Remarkably, both CCA CTCs organoid-derived exosomes and CCA cells-derived exosomes featuring pronounced TTN-AS1 expression demonstrated the capability to the proliferation and migratory potential of CCA cells. Validation of these outcomes was conducted in vivo experiments. Conclusions In conclusion, our study elucidating that CCA CTCs-derived exosomes possess the capacity to bolster the metastasis tendencies of CCA cells by transporting TTN-AS1. These observations underscore the potential of TTN-AS1 within CTCs-derived exosomes to serve as a promising biomarker for the diagnosis and therapeutic management of CCA.

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Immunohistochemical characterization of cancer-associated fibroblasts at the primary sites and in the metastatic lymph nodes of human intrahepatic cholangiocarcinoma

et al. 2019

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Coagulopathy associated with poor prognosis in intrahepatic cholangiocarcinoma patients after curative resection

Cited by 4 publications

References 24 publications

Comprehensive analysis of coagulation indices for predicting survival in patients with biliary tract cancer

Comprehensive analysis of coagulation indices for predicting survival in patients with biliary tract cancer

Circulating tumor cell-derived exosome–transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells

Immunohistochemical characterization of cancer-associated fibroblasts at the primary sites and in the metastatic lymph nodes of human intrahepatic cholangiocarcinoma

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