Monitoring aminoglycoside use in patients with severely impaired renal function.

Hydrophilic interaction chromatography combined with tandem mass spectrometry method for the quantification of tobramycin in human plasma and its application in a pharmacokinetic study

“…It has a narrow therapeutic range and monitoring of the drug is required to reduce serious side effects such as nephro and ototoxicity [1][2][3][4]. Dosage alterations based on the results of drug monitoring have been found to improve efficacy and minimize toxicity [5].…”