Molecularly imprinted sensor based on o-aminophenol for the selective determination of norepinephrine in pharmaceutical and biological samples

Rosy, .; Chasta, Himanshu; Goyal, Rajendra N.

doi:10.1016/j.talanta.2014.02.038

Cited by 36 publications

(22 citation statements)

References 39 publications

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“…This might be due to the merits of the electrochemical means of MIPs preparation such as (i) controllable film thickness, (ii) preparation of a compact film that adheres properly onto the signal transducer, and (iii) easier film preparation on the electrode surface compared to drop‐casting or composite formation. [ 68 ] Apart from these merits, it is equally a fact that this method of polymerization has helped in cutting the cost of MIP preparation through the formation of the desired MIPs film without the use of a cross‐linker and an initiator commonly used in traditional MIPs preparation. For instance, Rosy et al.…”

Section: Polymerization In Mips Based Sensors For Catecholamines Detectionmentioning

confidence: 99%

Molecularly imprinted polymers (MIPs) based electrochemical sensors for the determination of catecholamine neurotransmitters – Review

Elugoke

Adekunle

Fayemi

et al. 2020

Electrochemical Science Adv

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Molecularly imprinted polymers (MIPs) have been widely used for the modification of electrodes because of their native specificity for the intrinsic template molecules. The importance of catecholamines in the neurological and general well-being of every individual cannot be overemphasized. Disorders associated with the imbalance in catecholamine levels can be diagnosed with electrochemical sensors capable of their determination in the presence of other biological interferents in extracellular fluids. MIPs based sensors have been designed for selective and simultaneous determination of these catecholamines in the past decade. Efforts in this regard and details on the components and preparation of these MIPs were presented in this review.

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Section: Polymerization In Mips Based Sensors For Catecholamines Detectionmentioning

confidence: 99%

Molecularly imprinted polymers (MIPs) based electrochemical sensors for the determination of catecholamine neurotransmitters – Review

Elugoke

Adekunle

Fayemi

et al. 2020

Electrochemical Science Adv

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“…In addition, 2-hydroxyaniline, a derivative of aniline, contains hydroxyl and amino groups in its structural unit, and can be polymerized. The hydroxyl and amino groups in poly (2-hydroxyaniline) (PHA) can be oxidized and reduced electrochemically, and have been utilized in the fabrication of sensors [19].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Electrocatalytic Behaviour of Poy(aniline-co-2-hydroxyaniline) Coated Electrodes for Hydrogen Peroxide Electrooxidation

2019

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Polymer-coated electrodes are widely used for the detection and oxidation of hydrogen peroxide (H 2 O 2 ). Conducting polyaniline (PANI), poly (2-hydroxyanilne) (PHA), and their copolymer poly(aniline-co-2-hydroxyaniline) (PACHA) were electrochemically synthesized on a gold substrate for H 2 O 2 detection and analysis. Cyclic voltammetry (CV), square wave voltammetry (SWV), and differential pulse voltammetry (DPV) techniques were used for electroanalysis. Both PACHA and PANI greatly reduced the gold overpotential for H 2 O 2 oxidation with enhanced current densities. The PACHA-and PANI-coated electrodes showed oxidative peaks at 0.30 and 0.50 V, respectively, in the presence of 1.4 × 10 −6 M H 2 O 2 , while PHA-coated electrodes exhibited no response. The fabricated electrodes displayed a linear response towards H 2 O 2 in range of 2 × 10 −7 to 1.4 × 10 −6 M, with very low detection limits (LODs) of 1 × 10 −7 M (for PACHA) and 1.15 × 10 −7 M (for PANI) evaluated from CV data. In case of SWV and DPV, the LODs were found to be 1.78 × 10 −7 M (for PACHA) and 1 × 10 −7 M (for PANI), respectively. The materials exhibit high sensitivity of 650 A/Mcm 2 and show good stability. The PACHA-coated electrode shows better capacitance (1.84 × 10 −3 F) than PHA-(2.52 × 10 −4 F) and PANI-coated (1.17 × 10 −3 F) electrodes.

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“…Electrochemical methods are inexpensive and fast compared to chromatographic measurements, but applications are limited due to poor selectivity and interference of other metabolites present in biological samples. To enhance the selectivity, Molecularly Imprinted Polymers (MIPs) have been used [23]. MIPs, referred to as plastic antibodies, possess high affinity for their template molecules but have superior stability and are inexpensive compared to natural antibodies [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Electropolymerization has the advantages over preparation of monoliths that instead of particles an imprinted film is formed on the electrode, but the main drawback is that a conductive monomer is required [36]. Rosy et al [23] synthesized an imprinted polymer film with o-aminophenol and evaluated noradrenaline binding by determining the increase in peak current. By implementing the MIP into the sensor platform, the selectivity was enhanced compared to traditional noradrenaline electrochemical sensors.…”

Section: Introductionmentioning

confidence: 99%

Development of a novel flexible polymer-based biosensor platform for the thermal detection of noradrenaline in aqueous solutions

Casadio

Lowdon

Betlem

et al. 2017

Chemical Engineering Journal

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Molecularly Imprinted Polymers (MIPs) are synthesized for the neurotransmitter noradrenaline with the optimal composition and binding conditions being determined via optical batch rebinding experiments. Next, the obtained MIP polymer particles are mixed within screen-printed inks to produce mass-producible bulk modified MIPs screen-printed electrodes (MIP-SPEs). In this contribution, the supporting surface which the MIP-SPEs are screen-printed upon are explored to deviate from conventional polyester, to polyvinylchloride, tracing paper and household-printing paper. The performance of the MIP-SPEs are measured using the Heat-Transfer Method (HTM), a straightforward and low-cost detection technique based on thermal resistance. At first, the noise on the signal is minimized by adjusting the settings of the temperature feedback loop. Second, the response of the MIP-SPEs to noradrenaline is measured and compared for the different substrate materials. Sensors printed onto paper are considered in further experiments as their response to noradrenaline is the highest and advantageous material properties, including sustainability and flexibility of the material. Subsequently, dose-response curves are determined by simultaneously measuring HTM and Thermal Wave Transport Analysis (TWTA). The latter is a new thermal detection method that relies on the use of thermal waves and has the advantage of a short measurement time (2 min). With these thermal methods, it is possible to specifically detect noradrenaline in aqueous solutions and quantify it at relevant concentrations. In summary, by combining synthetic receptors with thermal measurement techniques it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules. Through exploring novel SPE substrates, a system is designed that is flexible and holds potential for the use in commercial biomedical devices and complex sensor architectures.

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Molecularly imprinted sensor based on o-aminophenol for the selective determination of norepinephrine in pharmaceutical and biological samples

Cited by 36 publications

References 39 publications

Molecularly imprinted polymers (MIPs) based electrochemical sensors for the determination of catecholamine neurotransmitters – Review

Molecularly imprinted polymers (MIPs) based electrochemical sensors for the determination of catecholamine neurotransmitters – Review

Enhanced Electrocatalytic Behaviour of Poy(aniline-co-2-hydroxyaniline) Coated Electrodes for Hydrogen Peroxide Electrooxidation

Development of a novel flexible polymer-based biosensor platform for the thermal detection of noradrenaline in aqueous solutions

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