Molecularly imprinted polymers as the epitome of excellence in multiple fields

Han, Yonghong; Tao, Juan; Ali, Nisar; Khan, Adnan; Malik, Sumeet; Khan, Hamayun; Yu, Chun-Hao; Yang, Yong; Bilal, Muhammad; Mohamed, Ahmed A.

doi:10.1016/j.eurpolymj.2022.111582

Cited by 29 publications

(15 citation statements)

References 649 publications

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“…Meanwhile the pore volume and pore diameter for Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @NIP were 0.272 cc g −1 , 3.85 nm and 0.076 cc g −1 , 3.82 nm, respectively. The surface area of Fe 3 O 4 @SiO 2 @MIP was higher than Fe 3 O 4 @SiO 2 @NIP due to the imprinting effect of DHA onto MIP surface 19,30,37–39 . Based on pore diameter size, the obtained materials owned mesoporous structure.…”

Section: Resultsmentioning

confidence: 96%

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Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Fauzia¹,

Andreas²,

Muzdalifah³

et al. 2023

Polymers for Advanced Techs

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Dihydroartemisinin (DHA) is an artemisinin derivative compounds that employs as malaria drug. Extraction and purification artemisinin derivatives by liquid extraction utilize organic solvent and results in mixtures of compounds requiring further purification process. In this study, core-shell magnetic molecular imprinted polymer (Fe 3 O 4 @SiO 2 @MIP) has been synthesized for DHA isolation. Methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) were employed as monomer and cross-linker, respectively. Fe 3 O 4 was modified by tetraethyl orthosilicate (TEOS) to enhance stability and prevent aggregation. Nonimprinted polymer (Fe 3 O 4 @SiO 2 @NIP) was also prepared as a comparison. The Fourier transform infrared (FTIR) represented O O stretching of O O C bond (1,2,4-trioxane ring) at 825 cm À1 denoting that DHA has been successfully attached to MIP. Meanwhile, the morphology of Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @NIP revealed uniform spherical-like form particle due to core-shell magnetic modification. The Brunaeur-Emmett-Teller (BET) revealed S BET of Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @-NIP was 70.16 and 19.56 m 2 g À1 , respectively. The prepared materials owned a superparamagentic behavior as indicated by narrow loop and low remanence and coercivity.The binding study indicated that Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @NIP were achieved optimum condition at pH 4, contact time 90 min and initial concentration 8 mg L À1 with adsorption capacity (q exp ) 1.026 mg g À1 for Fe 3 O 4 @SiO 2 @MIP and 0.806 for Fe 3 O 4 @SiO 2 @NIP. The selectivity of Fe 3 O 4 @SiO 2 @MIP was more than 60% in all over the ratio. The prepared MIP exhibited good selectivity toward DHA with imprinting factor (IF) 2.14 and selectivity coefficient (α) 3.43. The percent adsorption of Fe 3 O 4 @-SiO 2 @MIP did not changed after three times adsorption-desorption cycles. The result exhibited that Fe 3 O 4 @SiO 2 @MIP could effectively be used for DHA separation.

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Section: Resultsmentioning

confidence: 96%

“…The surface area of Fe 3 O 4 @SiO 2 @MIP was higher than Fe 3 O 4 @SiO 2 @NIP due to the imprinting effect of DHA onto MIP surface. 19,30,[37][38][39] Based on pore diameter size, the obtained materials owned mesoporous structure. capacity of Fe 3 O 4 @SiO 2 @MIP and Fe 3 O 4 @SiO 2 @NIP decreased as pH increased from 4 to 10.…”

Section: Resultsmentioning

confidence: 99%

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Fauzia¹,

Andreas²,

Muzdalifah³

et al. 2023

Polymers for Advanced Techs

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“…The results are tabulated in Table 3 . In such a way, the green sensing technology usage might help in the identification of these analyte(s) in many environmental samples and production procedures without any interference [ 55 , 56 , 57 , 58 , 59 ]. The comparison of current work with the already reported literature is shown in Table 4 .…”

Section: Resultsmentioning

confidence: 99%

Biomimetic Electrochemical Sensors Based on Core-Shell Imprinted Polymers for Targeted Sunset Yellow Estimation in Environmental Samples

Malik

Khan

et al. 2023

Biosensors

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Magnetic molecularly imprinted polymers (MMIPs) contain the predesigned specialized recognition capability that can be chosen to build credible functional materials, that are easy to handle and have a good degree of specificity. Hence, the given piece of work is intended to design a novel electrochemical sensor incorporating magnetite-based molecularly imprinted polymers. The building materials consisted of a cross-linker (EGDMA), reaction-initiator (AIBN), monomer (methylene succinic acid-MSA), and template molecule (Sunset Yellow-SY dye). MMIPs exhibited a diameter of 57 nm with an irregular shape due to the presence of cavities based on SEM analysis. XRD patterns exhibited crystallinity, as well as amorphous peaks that are attributed to polymeric and non-polymeric frameworks of MMIPs. The crystallite size of the MMIPs from XRD analysis was found to be 16.28 nm based on the Debye-Scherrer’s equation. Meanwhile, the FTIR bands showed the synthesis of MMIPs using monomer and methylene succinic acid. The sorption data at the optimized operating conditions (pH 2, sorbent dosage 3 mg, time 18 min) showed the highest sorption capacity of 40 mg/g. The obtained data best fitted to the Langmuir sorption isotherm and followed the pseudo-second-order kinetics. The magneto-sensors were applied for ultrasensitive, rapid, and simple sensing of SY dye. The electrochemical experiments were run at the operating condition range of (scan rate 10–50 mV/s, tads 0–120 s, pH 5–9, potential range 1–1.5 V for CV and 1–1.3 V for SWAdASV). The linear range of detection was set to 1.51 × 10−6 M to 1.51 × 10−6 M posing LOD and LOQ values of 8.6242 × 10−5 M and 0.0002874 M, respectively. The regression analysis value for the calibration was found to be 0.950. Additionally, high adsorption efficiency, selectivity, reusability, and strong structural stability of the magneto-sensors showed potential use for SY detection in real samples. These characteristics make MMIPs a viable electrochemical substrate for the detection of chemical contaminants in the environment and in health-related products.

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“…Functional monomers interact with the target molecule in the solution, establishing a network of the desired complex through covalent, noncovalent, and semicovalent interactions (Figure ). This synthesis method is categorized into three main segments based on the interactions during the rearrangement process between the target molecule and its functional monomer …”

Section: Synthesis Process Of Mipsmentioning

confidence: 99%

Molecularly Imprinted Polymer Technology for the Advancement of Its Health Surveillances and Environmental Monitoring

Sengar,

Kumari,

Sengar

et al. 2024

ACS Appl. Polym. Mater.

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Molecularly imprinted polymer (MIP) technology and its prospective used in the surveillance of the environment are the focus of this review article, which aims to give an in-depth understanding of the field. The approach of generating highly cross-linked polymeric structures with effective binding sites that precisely match the analyte of interest by templating with it is covered in the study as a means of producing biomimetic ligands. It also highlights the stability and robustness of MIPs, making them ideal for challenging environmental conditions. The originality of this paper lies in its exploration of various physical forms and synthesis techniques of MIPs, as well as the development of specialized MIPs to address specific challenges. It emphasizes the diverse applications of MIPs in environmental monitoring, including sample pretreatment, solid-phase extraction, microextraction, sensors, and chromatographic separations with the discussion on integration of MIPs with advanced analytical tools, highlighting the potential for enhancing the accuracy and reliability of environmental monitoring. Furthermore, the integration of MIPs with advanced analytical instruments opens up new possibilities for qualitative and quantitative evaluation of detection systems. Capillary electrochromatography and thin-layer chromatography are mentioned as the examples of analytical techniques that can be seamlessly integrated with MIPs. This integration enables improved accuracy and reliability in environmental monitoring, enhancing our understanding and protection of the environment. It not only explores the fundamentals of MIP technology but also delves into the synthesis methods, specialized MIPs, and integration with advanced analytical instruments. By providing this holistic view, the paper offers a valuable resource for researchers and practitioners interested in utilizing MIPs for environmental monitoring applications.

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Molecularly imprinted polymers as the epitome of excellence in multiple fields

Cited by 29 publications

References 649 publications

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Biomimetic Electrochemical Sensors Based on Core-Shell Imprinted Polymers for Targeted Sunset Yellow Estimation in Environmental Samples

Molecularly Imprinted Polymer Technology for the Advancement of Its Health Surveillances and Environmental Monitoring

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Molecularly imprinted polymers as the epitome of excellence in multiple fields

Cited by 29 publications

References 649 publications

Core–shell magnetic‐modified molecular imprinted polymer (Fe3O4@SiO2@MIP) for dihydroartemisinin recognition and separation

Core–shell magnetic‐modified molecular imprinted polymer (Fe3O4@SiO2@MIP) for dihydroartemisinin recognition and separation

Biomimetic Electrochemical Sensors Based on Core-Shell Imprinted Polymers for Targeted Sunset Yellow Estimation in Environmental Samples

Molecularly Imprinted Polymer Technology for the Advancement of Its Health Surveillances and Environmental Monitoring

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Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation

Core–shell magnetic‐modified molecular imprinted polymer (Fe₃O₄@SiO₂@MIP) for dihydroartemisinin recognition and separation