Molecularly Imprinted Polymer Technology for the Advancement of Its Health Surveillances and Environmental Monitoring

Abstract

Molecularly imprinted polymer (MIP) technology and its prospective used in the surveillance of the environment are the focus of this review article, which aims to give an in-depth understanding of the field. The approach of generating highly cross-linked polymeric structures with effective binding sites that precisely match the analyte of interest by templating with it is covered in the study as a means of producing biomimetic ligands. It also highlights the stability and robustness of MIPs, making them ideal for challenging environmental conditions. The originality of this paper lies in its exploration of various physical forms and synthesis techniques of MIPs, as well as the development of specialized MIPs to address specific challenges. It emphasizes the diverse applications of MIPs in environmental monitoring, including sample pretreatment, solid-phase extraction, microextraction, sensors, and chromatographic separations with the discussion on integration of MIPs with advanced analytical tools, highlighting the potential for enhancing the accuracy and reliability of environmental monitoring. Furthermore, the integration of MIPs with advanced analytical instruments opens up new possibilities for qualitative and quantitative evaluation of detection systems. Capillary electrochromatography and thin-layer chromatography are mentioned as the examples of analytical techniques that can be seamlessly integrated with MIPs. This integration enables improved accuracy and reliability in environmental monitoring, enhancing our understanding and protection of the environment. It not only explores the fundamentals of MIP technology but also delves into the synthesis methods, specialized MIPs, and integration with advanced analytical instruments. By providing this holistic view, the paper offers a valuable resource for researchers and practitioners interested in utilizing MIPs for environmental monitoring applications.

Target-Imprinted Polyaniline/Nb2O5 Nanoparticles as Electrochemical Interfaces for Monitoring Kidney Function

“…Herein, we report the application of Cre-PAni/Nb 2 O 5 nanoparticles for sensitive, selective, and noninvasive monitoring of Cre in human saliva. The objective and hypothesis of this research are to utilize the highly active Lewis acid function of Nb­(V) cations in Nb 2 O 5 nanoparticles , coupled with the principles of molecular recognition. , Nb 2 O 5 nanoparticles have excellent oxidizing capabilities and play a crucial role in charge transport . Molecular imprinting, on the other hand, is a straightforward way to produce target-selective polymers, i.e., using an antibody-mimicking function of the target-imprinted semiflexible organic-semiconductor (Cre-PAni), for the selective recognition and quantification of Cre in solution and complex mixtures.…”

4-Ethylphenyl Sulfate Detection by an Electrochemical Sensor Based on a MoS2 Nanosheet-Modified Molecularly Imprinted Biopolymer

“…Analytes, when removed via physical or chemical methods, leave behind a memorial site in the matrix of polymer specific to a particular analyte. MIPs have some specific advantages such as low cost of preparation, high affinity to the template, robustness, and long-term stability. − Since a few decades, neurotransmitters, such as dopamine (DA), serotonin, norepinephrine, etc., have made these biopolymers accessible for the synthesis of molecularly imprinted biopolymers (MIBPs). − Our group has previously worked on the fabrication of a polydopamine-MIP (PDA-MIP)-based electrochemical sensor for the detection of 4-EPS . However, the incorporation of nanomaterials, in this case MoS 2 nanosheets, in MIP-based electrochemical sensors showed enhanced sensitivity, a broader range of detection, and improved stability of the fabricated electrodes.…”