Molecularly imprinted polymer catalysis of a Diels-Alder reaction

Kirsch, Nicole; Hedin-Dahlström, Jimmy; Henschel, H.; Whitcombe, Michael J.; Wikman, Susanne; Nicholls, Ian A.

doi:10.1016/j.molcatb.2008.12.002

Cited by 79 publications

(50 citation statements)

References 51 publications

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“…45 Further developments in catalytic receptors based on MIPs will depend largely on the successful preparation of MIP-based catalysts which can react with water-soluble and practically important analytes. 46,47 In relation to protein detection, the integration of MIPs with acoustic, surface plasmon resonance or surface enhanced Raman sensors might seem to be the most promising platforms. 48,49 These sensors do not require the use of enzyme or fluorescent labels and could be used for the direct measurement of analyte concentrations.…”

Section: Detection Of Bindingmentioning

confidence: 99%

The rational development of molecularly imprinted polymer-based sensors for protein detection

et al. 2011

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The detection of specific proteins, as biomarkers of disease, health status, environmental monitoring, food quality, control of fermenters and civil defence purposes means that biosensors for these targets will become increasing more important. Among the technologies used for building specific recognition properties, molecularly imprinted polymers, molecularly imprinted polymers (MIPs) are attracting much attention. In this critical review we describe many of methods used for imprinting recognition for protein targets in polymers and their incorporation with a number of transducer platforms with the aim of identifying the most promising approaches for the preparation of MIP-based protein sensors.2

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Section: Detection Of Bindingmentioning

confidence: 99%

The rational development of molecularly imprinted polymer-based sensors for protein detection

et al. 2011

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“…Applications of molecularly imprinted materials have grown to include areas such as separation sciences and purification as extraction and chromatographic sorbents [3,4], chemical sensors [5], catalysis [6], drug delivery [7] and biological antibodies and receptors system [8]. Among the polymeric materials developed, MIPs are also one of the most attractive materials for bioanalytical and biomedical applications [9].…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymers for Pharmaceutical Compounds: Synthetic Procedures and Analytical Applications

Madikizela¹,

Tavengwa²,

Pakade³

2018

Recent Research in Polymerization

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In this chapter, the synthetic procedures for molecularly imprinted polymers (MIPs) for pharmaceutical compounds are discussed. Regardless of its limitations, such as production of irregular particles and loss of sample during processing (crushing and sieving), bulk polymerization has been widely used compared to say precipitation and suspension polymerization partly due to its simplicity in synthesis and robustness. A comparison of indomethacin removal from aqueous solution by MIP particles prepared using bulk polymerization to those obtained from suspension polymerization showed that the particles from the former exhibited higher adsorption capacity. Furthermore, the chapter explores the strengths and limitations relating the use of pharmaceutical compounds as uni-templates, multi-templates and dummy templates. Also, the analytical applications of MIPs are discussed in more details with particular focus on molecularly imprinted solid-phase extraction (MISPE) of pharmaceuticals from environmental samples. This application (MISPE) is currently the most exploited in literature as more pharmaceutical drugs find their way into environmental water bodies.

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“…Kirsch et al [49] presented a MIP able to catalyze Diels-Alder reactions. This is a cycloaddition reaction that is very useful in synthetic organic chemistry as a method for forming 6-membered systems with good control over regio-and stereochemical properties.…”

Section: Polymers With Unusual Reactivitymentioning

confidence: 99%

Molecularly Imprinted Polymers for Catalysis and Synthesis

Mirata

Resmini

2015

Molecularly Imprinted Polymers in Biotechnology

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The area of biomimetic catalysis based on molecular imprinted polymers has progressed considerably over the last two decades, with research efforts focused on developing catalysts for challenging reactions and on understanding the key factors in template structure and polymer morphology that influence efficiency and selectivity. Recent advances and significant achievements in the field presented in this chapter are organized according to four topics: hydrolytic reactions of challenging substrates, oxidase mimics, metallo-enzyme mimics, and polymers that display unusual reactivity, such as in the case of reactions for which enzymes don't exist, such as Diels-Alder and Kemp elimination. For each theme, significant examples for recent literature are presented and discussed.

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Molecularly imprinted polymer catalysis of a Diels-Alder reaction

Cited by 79 publications

References 51 publications

The rational development of molecularly imprinted polymer-based sensors for protein detection

The rational development of molecularly imprinted polymer-based sensors for protein detection

Molecularly Imprinted Polymers for Pharmaceutical Compounds: Synthetic Procedures and Analytical Applications

Molecularly Imprinted Polymers for Catalysis and Synthesis

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