Molecularly imprinted polymer beads for nicotine recognition prepared by RAFT precipitation polymerization: a step forward towards multi-functionalities

Zhou, Tongchang; Jørgensen, Lars; Mattebjerg, Maria Ahlm; Chronakis, Ioannis S.; Ye, Lei

doi:10.1039/c4ra04741a

Cited by 56 publications

(51 citation statements)

References 36 publications

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“…Nevertheless, the "living" characteristic of CRP is useful for continuous grafting of polymer on a MIP surface, and offers a convenient means for modifying a MIP surface to minimize nonspecific binding under different solvent conditions [23]. The terminal functional groups derived from the CRP reagents can also be used directly to conjugate MIPs with other functional materials without involving an additional polymer layer [24].…”

Section: Classical Versus Controlled Radical Polymerization Chemistrymentioning

confidence: 99%

Synthetic Strategies in Molecular Imprinting

2015

Molecularly Imprinted Polymers in Biotechnology

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This chapter introduces the basic principle and the synthetic aspects of molecular imprinting. First, the use of a molecular template to guide the location of functional groups inside molecularly imprinted cavities is explained. Three different mechanisms that ensure a molecular template associates with functional monomers or the imprinted polymers, that is, through reversible covalent, noncovalent, and sacrificial covalent bonds, are then described. The main focus is put on noncovalent molecular imprinting using free radical polymerization. The merits of using classical radical polymerization and more sophisticated, controlled radical polymerization are analyzed. After these synthetic chemistry aspects, the chapter continues to discuss the different polymerization processes that can be used to prepare well-defined polymer monoliths, microspheres, and nanoparticles. New top-down processing techniques that produce micro- and nanopatterns of imprinted polymers are also reviewed. The chapter finishes with a brief introduction to using imprinted polymers as building blocks to construct new functional materials and devices, which we consider as one important direction for further development.

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Section: Classical Versus Controlled Radical Polymerization Chemistrymentioning

confidence: 99%

Synthetic Strategies in Molecular Imprinting

2015

Molecularly Imprinted Polymers in Biotechnology

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“…Molecular imprinting polymers [17] can be prepared by various methods such as bulk polymerization [18], electropolymerization [19], suspension polymerization [20], emulsion polymerization, two-step polymerization [21], and precipitation polymerization [22]. Zhou et al [23] mentioned that the controlled/living radical polymerization (CRP) is used to prepare MIP microspheres as it permits more precise control over the molecular weight, composition, and end group functionality of the obtained polymers [24–27]. MIPs show excellent thermal and chemical stability and can be used in aggressive media [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Molecular Imprinting Polymer Microspheres of Piperine: Extraction of Piperine from Spiked Urine

Roland

Bhawani

2016

Journal of Analytical Methods in Chemistry

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Molecularly imprinted polymer (MIP) microspheres for Piperine were synthesized by precipitation polymerization with a noncovalent approach. In this research Piperine was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and 2,2′-azobisisobutyronitrile (AIBN) as an initiator and acetonitrile as a solvent. The imprinted and nonimprinted polymer particles were characterized by using Fourier transform infrared spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). The synthesized polymer particles were further evaluated for their rebinding efficiency by batch binding assay. The highly selected imprinted polymer for Piperine was MIP 3 with a composition (molar ratio) of 0.5 : 3 : 8, template : monomer : cross-linker, respectively. The MIP 3 exhibits highest binding capacity (84.94%) as compared to other imprinted and nonimprinted polymers. The extraction efficiency of highly selected imprinted polymer of Piperine from spiked urine was above 80%.

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“…The introduction of reversible addition-fragmentation chain transfer (RAFT) polymerization techniques into the molecular imprinting strategy has attracted signicant interest, which can solve the above problem. [10][11][12][13][14] For examples, Pan et al described an approach to obtain water-compatible MIPs by the facile surface-graing of functional polymer brushes via RAFT polymerization. 10 Titirici et al prepared thin lm MIPs around mesoporous silica beads by adopting covalent immobilization of azo initiators and RAFT-mediated living radical polymerization.…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of magnetic molecularly imprinted microspheres by RAFT precipitation polymerization for the fast and selective removal of 17β-estradiol

Dong

Wang

et al. 2015

RSC Adv.

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A facile strategy was developed to prepare magnetic molecularly imprinted microspheres (MMIMs) for the selective recognition and effective removal of 17-beta-estradiol (17b-E2) by reversible additionfragmentation chain transfer precipitation polymerization. One-pot synthesis was employed, which could simplify the imprinting process and shorten the experimental period. The resultant MMIMs displayed fast kinetics and high binding capacity, and the adsorption processes followed LangmuirFreundlich isotherm and pseudo-second-order kinetic models. Excellent recognition selectivity toward 17b-E2 was attained over other phenolic estrogens such as 17-alpha-E2, estriol and estrone. The magnetic property of MMIMs provided fast and simple separation, and the recycling process for magnetic solid phase extraction (MSPE) was sustainable at least five times without obvious efficiency decrease. Furthermore, the MMIMs-MSPE presented satisfactory recoveries within 71.7-108.3% with the precisions of 1.1-6.0% for spiked 17b-E2 in water, soil and food samples. The developed MMIMs-based method proved to be a convenient and practical way in sample pretreatment and targeted pollutants removal.

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Molecularly imprinted polymer beads for nicotine recognition prepared by RAFT precipitation polymerization: a step forward towards multi-functionalities

Abstract: Molecularly imprinted polymer beads synthesized by RAFT precipitation polymerization enable versatile surface functionalization and new applications.

Cited by 56 publications

References 36 publications

Synthetic Strategies in Molecular Imprinting

Synthetic Strategies in Molecular Imprinting

Synthesis and Characterization of Molecular Imprinting Polymer Microspheres of Piperine: Extraction of Piperine from Spiked Urine

One-pot synthesis of magnetic molecularly imprinted microspheres by RAFT precipitation polymerization for the fast and selective removal of 17β-estradiol

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