Molecularly imprinted beads by surface imprinting

Abstract

Molecular imprinting is a state-of-the-art technique for imparting molecular recognition properties to a synthetic polymeric matrix. Conventionally, the technique is easily carried out using bulk imprinting, where molecularly imprinted polymers (MIPs) are prepared in large chunks and post-treatment processes like grinding and sieving are then required. However, this strategy tends to produce sharp-edged, irregular MIP bits with a limited scope of direct application. In addition, due to the creation of binding sites within the polymeric bulk, the issue of the hindrance of adsorbate diffusion (especially in the case of macromolecules) during template rebinding makes the MIPs prepared through this approach unsuitable for practical applications. Thus over the years, many efforts to address the limitations of conventional molecular imprinting techniques have resulted in new imprinting methodologies. Systems like suspension and precipitation polymerization, where MIPs with tunable morphologies can be prepared, have been developed. Additionally, strategies like surface imprinting have also been employed. Ultimately, both of these approaches have been combined to prepare regularly shaped surface-imprinted MIP beads. Such an approach incorporates the advantages of both methodologies at the same time. Given their desirable physical morphologies and favorable adsorption kinetics, MIPs prepared in this manner show significant promise for industrial applications. Therefore, they will be the main focus of this review.

The study of core–shell molecularly imprinted polymers of 17β-estradiol on the surface of silica nanoparticles

“…However, traditional MIPs have many drawbacks (Ki et al, 2002;Carter and Rimmer, 2004), such as incomplete template removal, small binding capacity and slow mass transfer. Recently, a molecular imprinting technique on the surface of nanomaterials has emerged, which can overcome above disadvantages effectively (Hayden et al, 2006;Tatemichi et al, 2007;Tan and Tong, 2007).…”

Biosensing Applications of Molecularly Imprinted Nanomaterials

“…This is especially important in sensor application, where a high sensitivity and a short response time are desired [87]. Accordingly, the controlled deposition of MIP nanostructures for sensor applications has also been investigated.…”

“…Many efforts have been made to prepare MIPs in an optimizing form that controls templates to be situated at the surface or in the proximity of the material's surface [75][76][77][78][79][80][81][82][83][84][85][86][87] so as to solve the problems of limited mass transfer and template removal often associated with the traditional technique of molecular imprinting. Surface imprinting has been widely studied as an effective approach.…”

Flow injection chemiluminescence sensor using core-shell molecularly imprinted polymers as recognition element for determination of dapsone

“…Therefore, they exhibit some disadvantages including incomplete template removal, small binding capacity, slow mass transfer, and irregular materials shape. However, the surface molecular imprinting technique has developed dramatically these years for the purpose of overcoming the drawbacks stated above effectively [18][19][20][21][22][23][24][25]. A thin film of imprinted polymer grafted onto the surfaces of beads can be obtained by the surface imprinting technique.…”