Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: Implications for specific immunotherapy

Phleum pratense molecular pattern across Italy

“…On the contrary, the pollen quantity significantly varied with a gradient from North to South with the exception of Liguria, where very low values were observed. The present molecular outcomes are substantially consistent with previous surveys conducted in Italy, that showed the preeminence of IgE reactivity to Phl p 1 and Phl p 5 (11)(12)(13). In particular, Phl p 1 appears as the most important species-specific Phl p allergen.…”

Molecular Allergology between Precision Medicine and the Choosing Wisely initiative

“…A growing spectrum of molecules, representing single allergens of clinical relevance have been identified, characterized and produced for commercial in vitro assays. This 'component resolved diagnosis' (CRD) thus allows a detailed molecular profiling of the polyclonal IgE repertoire of the allergic patient [8].…”

Molecular diagnosis and precision medicine in allergy management

“…It remains firm that molecular allergy diagnosis, especially with multiplexed instruments, remains a third-line approach, to be used only in patients with a complex polysensitization profile, and when the standard diagnostics are insufficient to choose the appropriate allergen(s) for AIT [12]. On the other hand, a "tailored" AIT, using only the genuine sensitizers seems difficult to realize, since there are too many different sensitization profiles [39][40][41], and so far, commercial extracts (that are less expensive) perform as well as purified/recombinant molecules for AIT [42,43]. Allergen specific immunotherapy (AIT) is a well-documented effective treatment for respiratory and hymenoptera venom allergy [44][45][46][47][48][49].…”