Molecular Profiles of Endometrial Hyperplasia and Endometrial Intraepithelial Neoplasia

Levakov, S A; Шешукова, Н. А.; Кедрова, А. Г.; Fedotova, A.S.; Obukhova, Obukhova E.A.

doi:10.17650/1994-4098-2018-14-2-76-81

Cited by 8 publications

(11 citation statements)

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“…The results of our work contradict the data that in normal endometrium the synthesis of VEGF is stimulated by the influence of estradiol, in neoplasia this effect worsens or disappears. Although researchers have studied a highly significant negative relationship between VEGF and progesterone receptor concentrations in endometrial hyperplasia, there is no correlation between VEGF and progesterone receptor expression [2,3,9]. However, it should be borne in mind that the etiopathogenetic mechanisms of development of endometrial tissue malignancy are not definitively established, the influence of hormonal factors exists, but it is not always associated with cancer risks, because in our work were more active processes in the postmenopausal period.…”

Section: Fig 2 Expression Of Vegf In Endometrial Cells In Different Pathological Conditions In Different Age Categories (Ru)mentioning

confidence: 74%

“…A clear tendency to increase the prevalence of hormone-dependent diseases related to preproliferative processes and endometrial cancer are observed against the background of increasing their incidence and rejuvenation of the age of manifestation [1,3,13]. Unspecified information about the etiopathogenesis of hyperplastic processes limits the possibilities of therapeutic treatment and obtaining positive results.…”

Section: Introductionmentioning

confidence: 99%

“…Unspecified information about the etiopathogenesis of hyperplastic processes limits the possibilities of therapeutic treatment and obtaining positive results. The lack of evidence base, the increased list of contraindications to hormone therapy cause the ineffectiveness of therapeutic measures and the growth of malignancy [3,4,15,18].…”

Section: Introductionmentioning

confidence: 99%

“…Microcirculatory-tissue theory, as a new paradigm of carcinogenesis, currently occupies one of the leading places in clinical and scientific research [1,3,4,6]. It has a certain role in molecular mechanisms of oxygen homeostasis regulation control.…”

Section: Introductionmentioning

confidence: 99%

“…The level of VEGF expression progressively decreases after birth, and is at low levels in most tissues except the places with active angiogenesis: ovaries, uterus, skin [2,3]. Simple disorders of cell respiration do not lead to malignancy, it is necessary that the disorders were irreversible and passed on generation of cells, but did not cause their death [1,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Expression of the VEGF marker in endometrial cells in hyperplastic processes

Chumak¹

2020

J Educ Health Sport

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Hormone-dependent diseases related to preproliferative processes and endometrial cancer have a clear tendency to increase and rejuvenate. The purpose: to study the expression of VEGF marker in endometrial cells under physiological, hyperplastic, atypical conditions in women's different age periods. 2196 pathomorphological findings of endometrial tissue samples in women with clinical manifestations requiring surgical treatment have been analyzed. VEGF expression was performed in endometrial tissue samples of 458 women of late reproductive, perimenopausal and postmenopausal age. Each age category is characterized by its morphofunctional features of the endometrial tissue. Results. The frequency of detection of hyperplastic processes, atypical hyperplasia and adenocarcinoma indicates that starting from the period after 40 y.o. the mechanisms of initiation and development of factors in the system of self-sufficiency in mitogenic stimuli, constant proliferation and insensitivity to antimytogenic signals", loss of "Hayflick's limit", reduced ability to apoptosis, propensity to immortalization take place. Conclusion: The expression of VEGF concentration in endometrial tissue as an inducer of angiogenesis is increased in hyperplastic processes. Significant growth is observed in the processes of atypical hyperplasia, especially in the postmenopausal period. Determination of VEGF concentration in endometrial proliferative processes can be a promising marker for diagnosing the risk of atypical conditions and their prognosis. Research in this direction is quite relevant.

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Section: Fig 2 Expression Of Vegf In Endometrial Cells In Different Pathological Conditions In Different Age Categories (Ru)mentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Expression of the VEGF marker in endometrial cells in hyperplastic processes

Chumak¹

2020

J Educ Health Sport

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Стан Клітинного Імунітету В Жінок Пре- Та Менопаузального Віку З Гіперпластичними Процесами Ендометрія

Slyva¹,

Selskyy²,

Kuziv³

et al. 2020

BMBR

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Мета роботи. Вивчити стан клітинного імунітету в пацієнтів із гіперпластичними процесами ендометрія. Матеріали і методи. Вивчено біопсійний матеріал та проаналізовано показники клітинного імунітету в 33 жінок пре- та менопаузального віку, яких поділили на три групи: першу групу складали 11 жінок із простою гіперплазією ендометрія без атипії; другу – 2 жінки з простою атиповою гіперплазією ендометрія; третю групу – 20 жінок із комплексною гіперплазією ендометрія без атипії. Контрольну групу складали 12 жінок без ознак захворювань ендометрія. Проведено дослідження низки параметрів: визначення відносної та абсолютної кількості різних субпопуляцій лімфоцитів крові, циркулюючих імунних комплексів, показників функціональної та проліферативної активності імунних клітин у сироватці венозної крові. Результати й обговорення. У жінок з гіперпластичними процесами ендометрія виявлено виражені порушення імунологічного гомеостазу, які проявлялися Т-лімфоцитопенією, дисбалансом субпопуляцій Т-клітин, здебільшого за рахунок зниження циркулюючих Т-хелперів/індукторів, що супроводжувалось зниженням коефіцієнта CD4/CD8 та свідчило про формування вторинного імунодефіциту. Індивідуальний аналіз імунограм хворих із гіперпластичними процесами показав наявність імунодефіциту в усіх обстежуваних пацієнток, проте у жінок із простою гіперплазією без атипії він проявляється гіпосупресією, у хворих з простою атиповою гіперплазією ендометрія більш вираженим супресорним варіантом, а у жінок із комплексною гіперплазією ендометрія мало місце пропорційне зниження індексу CD4/CD8. Порушення функції імунітету виявлялося в різкому зниженні фагоцитарного індексу нейтрофілів у всіх жінок із гіперпластичними процесами ендометрія та зниженні проліферативної активності лімфоцитів у жінок із простою гіперплазією ендометрія без атипії й тенденцією до її підвищення у хворих із простою атиповою гіперплазією ендометрія. Висновки. В усіх пацієнток із різними видами гіперплазії ендометрія виявлено зростання дрібних циркулюючих імунних комплексів та збільшення концентрації середніх циркулюючих імунних комплексів у хворих із простою гіперплазією без атипії та комплексною гіперплазією ендометрія.

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Age-related relationship between the development of hyperplastic processes and VEGF expression in endometrial cells

Chumak

Shapoval

Artyomenko

2020

J Educ Health Sport

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The existence of a clear tendency to increase the prevalence of hormone-dependent diseases and endometrial cancer against the background of increasing the frequency of their occurrence and rejuvenation of the age of manifestation leads to the search for new possible markers of diagnosis and prognosis of the development of pathological process. Angiogenesis is one of the forms that lead to the formation of new blood vessels, with an increased metabolic need for perfusion of existing vessels. The vascular endothelial growth factor family (VEGF) is a protein that is the major inducer of angiogenesis. The objective: To study the expression of VEGF in endometrial cells in proliferative, hyperplastic, atrophic states at women's different ages. Materials and methods. A retrospective analysis of medical records of the pathohistological bureau for the period 2014-2016 was conducted. 2196 pathomorphological findings of endometrial tissue specimens have been examined. Estimation of VEGF expression was performed in 417 endometrial specimens, in the cohorts of the study: in the reproductive, perimenopausal, postmenopausal periods, respectively, in groups with physiological endometrial proliferation phase, hyperplastic, atypical, atrophic endometrium. The results were statistically processed. Results and discussion. Analyzing the data presented, higher VEGF expression was detected in atypical hyperplasia in all age categories, but it was likely that higher rates were established in the postmenopausal period, 210 with atypical endometrial hyperplasia, suggesting physicians' alertness to the process in this category.Probably low were indexes found at atrophic endometrium in this age category, which confirms the endometrial preservation of its growth factors, and in the presence of processes that stimulate the proliferation of the organ, they can trigger at the molecular-genetic level, neoplastic mechanisms. The data of the retrospective analysis confirm the growth of atypical form of hyperplastic processes and their maximum detection in the age categories 41 -45 and 46 -50 years old, and the beginning of detection of endometrial malignancy from the age of 46 -50 years old, with a gradual increase with age. Conclusions. Expression of VEGF level in endometrial tissue cells as an inducer of angiogenesis can be a promising marker for the diagnosis of the risk of proliferative conditions and their prognosis, especially in relation to other markers characterizing immunohistochemical and molecular genetic cellular parameters.

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Molecular Profiles of Endometrial Hyperplasia and Endometrial Intraepithelial Neoplasia

Cited by 8 publications

References 0 publications

Expression of the VEGF marker in endometrial cells in hyperplastic processes

Expression of the VEGF marker in endometrial cells in hyperplastic processes

Стан Клітинного Імунітету В Жінок Пре- Та Менопаузального Віку З Гіперпластичними Процесами Ендометрія

Age-related relationship between the development of hyperplastic processes and VEGF expression in endometrial cells

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