Molecular mediators and trauma: effects of accidental trauma on the production of plasma elastase, IL-6, sICAM-1, and sE-selectin

Giannoudis, Peter V.; Smith, Riannon; Ramsden, C. H.; Sharples, D.; Dickson, R. A.; Guillou, P. J.

doi:10.1016/0020-1383(96)86864-1

Cited by 17 publications

(9 citation statements)

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“…Severity assessment in trauma is classically based on anatomical scores, namely, the ISS [ 16 ], combined or not with physiological variables and age. However, anatomical damage seems to be associated with more marked systemic inflammation and endotheliitis, as shown by the association between IL-6 levels at admission and ISS in our study and other studies [ 17 , 18 ]. Finally, systemic inflammation is a driver of organ dysfunction and worse outcome.…”

Section: Discussionsupporting

confidence: 85%

“…Our study also confirms its association with outcome, suggested by others [ 22 ], as IL-10 levels at 72 hours were correlated with MODS development (AUC = 0,700 for a cut-off level > 4,93 pg/mL) and especially with death (AUC = 0,871 for a cut-off level > 8,24 pg/mL). ICAM-1, as IL-6, is a marker of endothelial inflammation and dysregulation and its levels have also been shown, in previous studies, to be correlated with the severity of the lesions and with MODS [ 17 , 23 ]. In our study, ICAM-1 levels at 24, 48, and 72 hours were associated with MODS development but not with death and the association was much weaker than that for IL-6 and IL-10 at 72 hours.…”

Section: Discussionmentioning

confidence: 99%

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Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome

Sousa

Raposo²,

Fonseca³

et al. 2015

Disease Markers

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Introduction. Severity and outcome assessments are crucial in trauma. Our aim was to describe the role of a group of cytokines (TNFα, IL-6, IL-10, and HMGB-1) and ICAM-1 as severity and outcome assessment tools and their kinetics in the first 72 h after severe trauma. Materials and Methods. Authors designed a prospective cohort study of severe polytrauma patients (ISS > 15) in a level 1 Trauma Centre. Cytokines and ICAM-1 levels and Th1/Th2 ratios were assessed at admission, 24, 48, and 72 h. SIRS, SIRS with hypoperfusion, and shock were identified. Outcomes considered were ICU admission, ARDS, MODS, and death. Results. Ninety-nine patients were enrolled (median ISS: 29 and age 31). There was an early release of pro- and anti-inflammatory mediators with higher values at admission (except for ICAM-1). On admission, IL-6 was associated with ISS, IL-10 with SIRS with hypoperfusion, and HMGB-1 with shock. Several cytokines were associated with outcomes, especially IL-6 and IL-10 at 72 h with MODS and death. Low TNFα/IL-10 and IL-6/IL-10 ratios at 24 and 72 h were associated with MODS and death. Conclusions. Pro- and anti-inflammatory responses occur simultaneously and earlier after injury. Cytokines may be useful for outcome assessment, especially IL-6 and IL-10. Low Th1/Th2 ratio at 24 to 72 h is associated with MODS and death.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome

Sousa

Raposo²,

Fonseca³

et al. 2015

Disease Markers

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“…15 However, levels of soluble Eselectin and soluble ICAM-1 were found to be significantly raised in the plasma by the third day after injury, the magnitude of the increase being related to the degree of injury. 18 Law et al 112 reported a significant correlation between the elevated levels of soluble ICAM-1 and the later occurrence and severity of MODS. Post-traumatic MODS has also been associated with an increased number of CD11b/CD18 receptors on the leucocytes and an upregulation of the oxidative burst.…”

Section: Markers Of Mediator Activitymentioning

confidence: 99%

“…17 Numerous studies have shown that stimulation of a variety of inflammatory mediators takes place immediately after trauma. 18,19 This response initially corresponds to the first-hit phenomenon. Several investigators have also highlighted the issue of secondary surgical procedures acting as additional inflammatory insults or second-hit phenomena.…”

Section: The Journal Of Bone and Joint Surgerymentioning

confidence: 99%

Inflammatory serum markers in patients with multiple trauma

Giannoudis

Hildebrand

Pape

2004

The Journal of Bone and Joint Surgery. British volume

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140

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“…Following trauma, patients are subjected to dynamic alterations in the haemodynamic, metabolic, and immune responses that are largely orchestrated by endogenous mediators referred to as cytokines [ 3 ]. Numerous studies have shown that stimulation of a variety of inflammatory mediators takes place immediately after trauma [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluating Nuclear Factor NF-κB Activation following Bone Trauma: A Pilot Study in a Wistar Rats Model

Salles¹,

Gehrke²,

Shibli³

et al. 2015

PLoS ONE

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The present study investigated the moment of peak NF-kB activation and its dissipation in the cortical bone in the femur of Wistar rat stimulated by surgical trauma. Sixty-five Wistar rats were divided into 13 groups (n = 5 per group): eight experimental groups (expG 1–8) divided based on the euthanasia time point (zero, 1 h, 2 h, 4 h, 6 h, 8 h, 12 h and 24 h) and five sham control groups (conG 1–5) killed at zero, 1 h, 2 h, 4 h and 6 h, respectively. A 1.8-mm-diameter defect was generated 0.5 mm from the femur proximal joint using a round bur to induce the surgical trauma. Overall, the activation peak of NF-κB in the cortical bone was 6 h (expG5 group) independent of the evaluated position; this peak was significantly different compared to those in the other groups (p < 0.05). The surgical trauma resulted in a spread of immune markings throughout the cortical bone with an accentuation in the knee region. The present study provides the first evidence that the NF-κB activation peak was established after 6 hours in the cortical bone of Wistar rats. The signs from a surgical trauma can span the entire cortical bone and are not limited to the damaged region.

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Molecular mediators and trauma: effects of accidental trauma on the production of plasma elastase, IL-6, sICAM-1, and sE-selectin

Cited by 17 publications

References 0 publications

Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome

Measurement of Cytokines and Adhesion Molecules in the First 72 Hours after Severe Trauma: Association with Severity and Outcome

Inflammatory serum markers in patients with multiple trauma

Evaluating Nuclear Factor NF-κB Activation following Bone Trauma: A Pilot Study in a Wistar Rats Model

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