Inflammatory serum markers in patients with multiple trauma

Giannoudis, Peter V.; Hildebrand, Frank; Pape, Hans-Christian

doi:10.1302/0301-620x.86b3.15035

Cited by 140 publications

(115 citation statements)

References 133 publications

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“…Another, larger study found the opposite, with the median CRP concentration 24 hours postoperatively being higher in dogs undergoing ovariohysterectomy than in dogs undergoing orthopaedic procedures 9 . In human studies, no correlation has been found between serum CRP concentration and severity of injury or survival 15 . In other words CRP appears to be a sensitive indicator of trauma but cannot be used as a reliable quantitative measure of trauma.…”

Section: Discussionmentioning

confidence: 94%

“…The synthesis of positive APPs is stimulated by various proinflammatory cytokines in response to tissue injury or infection. The main stimulatory cytokines are interleukin-1, interleukin-6 and tumour necrosis factor alpha 10,15,24,29 . The exact functions of the APPs are not completely understood, but it is known that they regulate and coordinate the body's response to tissue injury.…”

Section: Introductionmentioning

confidence: 99%

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An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

Nevill¹,

Leisewitz²,

Goddard³

et al. 2010

J. S. Afr. Vet. Assoc.

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The extent of trauma in a patient can be difficult for a clinician to quantify. A prospective study was performed on 2 groups of dogs undergoing either ovariohysterectomy or hemilaminectomy. The serum activity of creatine kinase and serum concentration of C-reactive protein were evaluated preoperatively and then at 4, 6, 8, 12, 24 and 48 hours postoperatively in both groups. The results were compared statistically both within and between the 2 groups. A wide range of results was found at each time point for both analytes although there were no significant differences for either analyte between the 2 surgical groups preoperatively. Thereafter there were significant differences in creatine kinase activity levels between the 2 groups. C-reactive protein concentration results were very similar in the 2 groups with no statistical difference at any time point. The results of this study suggest that the evaluation of CK and CRP at any one time point in a traumatised animal is of limited value. However, the evaluation of the trend of these 2 analytes, even over a relatively short time period, may allow for useful prognostication in clinical cases

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

Nevill¹,

Leisewitz²,

Goddard³

et al. 2010

J. S. Afr. Vet. Assoc.

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show abstract

“…The current end points used to guide resuscitation, such as blood pressure, urine output, heart rate, base deficit, and serum lactate levels, are global markers that may underestimate occult tissue hypoperfusion. In the future, more sensitive measures of tissue oxygenation involving polarographic or near-infrared technologies 65 and markers of inflammation and coagulation 66,67 that better reveal the physiologic condition of a patient are likely to replace simple temporal distinctions. They will provide more accurate criteria with which to determine when a patient is ''ready'' for definitive internal fixation of a femoral shaft fracture or other major orthopaedic injuries.…”

Section: Discussionmentioning

confidence: 99%

Delayed Internal Fixation of Femoral Shaft Fracture Reduces Mortality Among Patients with Multisystem Trauma

Morshed

Miclau

Bembom

et al. 2009

The Journal of Bone and Joint Surgery-American Volume

126

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“…First, injury severity may explain the results. Proinflammatory cytokine concentrations relate to the degree of tissue injury [44,100]. Although the injury may have been insufficient to stimulate specific cytokines detectably, the cumulative effect of cytokines may underlie detectable CRP production.…”

Section: Elevation Of Crp But Not Primary Pro-inflammatory Cytokinesmentioning

confidence: 99%

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Klyne

Barbe

Hodges

2017

Brain, Behavior, and Immunity

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Please cite this article as: Klyne, D.M., Barbe, M.F., Hodges, P.W., Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain, Brain, Behavior, and Immunity (2016), doi: http://dx.doi.org/10. 1016/j.bbi.2016.10.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and control participants, and in a separate analysis, for those with "high-pain" (VAS≥4) and "low-pain" (VAS<4). The relationships between biomarkers and all other variables, including other cytokines/CRP were assessed. CRP was higher in LBP than controls and in those with high-than low-pain (p<0.01). IL-6 was higher in those with high-than low-pain (p<0.05), but not controls. Various pain and non-pain factors were associated with each biomarker differently. These findings suggest systemic CRP and IL-6 are important contributors to inflammation in the early post-onset phase of LBP and that various factors can shape these responses.3

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Inflammatory serum markers in patients with multiple trauma

Cited by 140 publications

References 133 publications

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

Delayed Internal Fixation of Femoral Shaft Fracture Reduces Mortality Among Patients with Multisystem Trauma

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

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