Molecular Mechanisms of Urolithiasis

Green, William; Ratan, Hari L.

doi:10.1016/j.urology.2012.12.039

Cited by 13 publications

(12 citation statements)

References 24 publications

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“…These plaques originate adjacent to the thin limbs of loops of Henle as spherical particles, which could be related to the high local ion concentrations at this site, and can extended to the interstitium. [14][15][16] Recent studies have investigated the role of oxalate-degrading bacteria. These form apatite structures that serve as a crystallization center for the formation of stones and could be a pharmacological target to avoid the nucleation process.…”

Section: Formation Of Renal Stonesmentioning

confidence: 99%

Effectiveness of Herbal Medicine in Renal Lithiasis: a Review

González

Pieters

Hernández

2020

Smj

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The renal lithiasis is a frequent disease that affect between 4-15% of worldwide population with a high percentage of recurrences. The composition of the stone is variated, but, more than 80% of uroliths are of calcium oxalate. The mechanisms involved in the formation of calcific stones are not fully understood and the available treatment not permit the prevention and destruction of the stones at same time. For these reasons, many studies have been focused to understand the mechanism involved in the renal lithiasis and in the development the new drugs for the treatment and prevention of this pathology and its recurrences. In this paper, it is shown a review about formation of calcific stones, their treatment and the effectiveness of the herbal medicine as alternative treatment. Also, a list of antilithiatic remedies of cuban herbal medicine is showed.

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Section: Formation Of Renal Stonesmentioning

confidence: 99%

Effectiveness of Herbal Medicine in Renal Lithiasis: a Review

González

Pieters

Hernández

2020

Smj

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“…These apatite deposits termed as Randall's plaques, on being constantly exposed to calyceal urine due to the loss of urothelium then attract organic substances like lipids, glycosaminoglycans and urinary proteins such as osteopontin and TammHorsfall protein that form a matrix on which accumulate apatite crystals that again get coated with a layer of urinary proteins and other organic substances and so on, forming a multilayered sandwich of apatite and organic matrix. These multiple layers then form an attachment site for calcium oxalate crystals where they eventually grow and form stones [7,[9][10][11][12][13] .…”

Section: Fixed Particle Theorymentioning

confidence: 99%

Urolithiasis: An Update on Diagnostic Modalities and Treatment Protocols

Bawari¹,

Sah²,

Tewari³

2017

Journal of Pharmaceutical Sciences

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Sweta, et al.: Diagnosis and Treatment of UrolithiasisUrolithiasis or urinary stone disease is a ubiquitous affliction that spares no geographical region or demographic. Plenty of research is being carried out in quest for mitigating this disease condition. However, any detailed information that could impart knowledge on all the major aspects of the subject in an unfractionated form is still deficient. This review is an attempt to revive the existing knowledge on urolithiasis, basically focused on its diagnosis and treatment and to provide a comprehensive data and up-to-date information on the subject matter. This article also focuses on synthetic drugs and formulations available for the treatment of urolithiasis in the global market and provides a section pertaining to risk factors and dietary preventive measures for urolithiasis.

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“…Type I lesions were tiny calcified plaques located in the interstitial tissue below the surface epithelium of the renal papillae which progressively became exposed to the urine by the erosion of the epithelium overlying the plaque. Type II lesions contained of calcific masses found in the terminal parts of the ducts of Bellini [19].…”

Section: Randall's Plaque Theorymentioning

confidence: 99%

Nephrolithiasis - An updated Review in Relation to Diagnosis, Prevention and Treatment

Kapoor¹,

Rb²,

Dadarwal³

2017

OAJTMR

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Nephrolithiasis or urinary stone disease is a common problem across the world. Ample of research is going on in expedition for extenuating this disease condition. The procedure of preparing stones in the kidney, bladder or urethra is called as Nephrolithiasis. Stones form twice as often in men as women. The characteristic of stones that impede the renal pelvis is unbearable, blinking pain that goes from the flank to the groin or to the genital area and inner thigh. Control diet, use of prescribed medicines, and proper nutrient use can assist in thwart the development of kidney stones. Obe¬sity surge the threat of kidney stones. However, diminish in weight could deterrence of kidney stones if taken with a high ani¬mal protein intake. A vigilant medical and dietary history, stone analysis, serologic tests, and urine analysis comprise the preliminary screening in patients who have been identified with stones. Computed tomography and multi detector computed tomography played vital role in exploration of choice for the characterization of urinary stone disease. The appearance of dual-energy CT has further armoured the pre-eminence of this modality over other imaging techniques in the management of nephrolithiasis. This review is an effort to revitalize the previous data available for nephrolithiasis, basically work on its diagnosis and healing and endow with comprehensive and up-to-date information on area under discussion. This article also put light on synthetic drugs and medicines accessible for the mitigation of nephrolithiasis in the internationally and also discuss a part mentioning risk factors and management of nephrolithiasis.

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Molecular Mechanisms of Urolithiasis

Cited by 13 publications

References 24 publications

Effectiveness of Herbal Medicine in Renal Lithiasis: a Review

Effectiveness of Herbal Medicine in Renal Lithiasis: a Review

Urolithiasis: An Update on Diagnostic Modalities and Treatment Protocols

Nephrolithiasis - An updated Review in Relation to Diagnosis, Prevention and Treatment

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