Sweta, et al.: Diagnosis and Treatment of UrolithiasisUrolithiasis or urinary stone disease is a ubiquitous affliction that spares no geographical region or demographic. Plenty of research is being carried out in quest for mitigating this disease condition. However, any detailed information that could impart knowledge on all the major aspects of the subject in an unfractionated form is still deficient. This review is an attempt to revive the existing knowledge on urolithiasis, basically focused on its diagnosis and treatment and to provide a comprehensive data and up-to-date information on the subject matter. This article also focuses on synthetic drugs and formulations available for the treatment of urolithiasis in the global market and provides a section pertaining to risk factors and dietary preventive measures for urolithiasis.

Genotypic variations were observed among 6 variants and an indigenous one as a control. An efficient genotype OCD(L) of Ocimum sanctum had the greatest content of chlorophylls [2.15 g kg −1 (FM)], Chl a/b ratio of 1.86, net photosynthetic rate of 0.72 mg(CO 2 ) m −2 s −1 , and 1.56 % oil formation. Methyl chavicol formed 50.31 % of total oil in OSP-6 genotype, which had also maximum peroxidase activity [ΔOD 2.4 mg −1 (protein)] and maximum production of eugenol (30.44 % of total oil). We found an oxido-reducible reaction of peroxidase and high bands of peroxidase isoenzymes in this OSP-6 genotype for the formation of monoterpene essential oil(s) and possibly the major constituents of eugenol through the high production of photosynthates.

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Two experiments are conducted to find out the effect of rice bran crude lecithin on rumen ecology, milk fat quality, metabolic indices, and leptin (LEP) gene expression.In first experiment, 12 crossbred calves are randomly divided into two groups, that is, RBCL-0 and RBCL-6, and they are fed wheat straw based diet with concentrate mixture containing 0% RBCL (CM1) and 6% RBCL (CM2), respectively, for 120 d for rumen fermentation study. Ruminal ammonia-N and short chain fatty acids and rumen microbes are nonsignificantly affected in RBCL calves. In second experiment, 12 lactating cows are randomly divided into RBCL-0 and RBCL-6 groups and fed CM1 and CM2 concentrate along with napier grass as roughage. In milk fatty acid profile, C16:1 fatty acid is significantly lower while cis-C18:1 is significantly higher in the RBCL supplemented cows. The atherogenic index and thrombogenic index are 16 and 19% lower while health promoting index, polyunsaturated saturated fatty acids, and hypocholesterolaemic/hypercholesterolaemic are 16, 10, and 16, respectively, higher in RBCL-6 cows. The mean nonesterified fatty acid and β-hydroxy butyric acid value is lower while LEP gene expression is higher in RBCL supplemented cows than control cows. The milk income is higher in RBCL cows. Finally, it can be concluded that RBCL at 6% in concentrate mixture of dairy ration do not adversely affect the rumen ecology. Although RBCL has capacity to enhance health properties of milk fat along with profitability, still more studies are warranted.Practical applications: Cow milk has always been an important component of the human diet in the world. The milk composition, especially fat, is directly influenced by feeding regime in dairy animals. In the milk fat, the unsaturated fatty acids (mainly polyunsaturated fatty acids) help in improving the health condition of consumers along with the keeping quality of milk. In this series, rice bran crude lecithin was used in the dairy ration and found that it altered certain metabolic parameters and gene expression, which may be beneficial for animal health without altering rumen fermentation.Although RBCL substantially modify the milk fatty acid profile and improves the fat indices which will enhance the human health by protecting them from cardiovascular diseases.

The present study was conducted to evaluate the effect of rice bran crude lecithin (RBCL) on nutrient digestion and balance, performance, methanogenesis, blood and rumen profile. Eighteen crossbred calves were randomly divided into three groups; RBCL-0, RBCL-8 and RBCL-12 and fed wheat straw based diet with concentrate mixture containing 0, 8 and 12 % RBCL respectively. The dry matter, organic matter and crude protein intake were comparable but tended to decrease with the RBCL levels. The digestibility of dry matter, organic matter, total carbohydrate and gross energy tended to decrease while crude protein and ether extract digestibility tended to increase were with RBCL levels. The fibre fractions (NDF and ADF) digestibility was significantly (P < 0.01) lower in RBCL supplemented groups in comparison to control group. The body weight gain and average daily gain tended to decrease with increasing the level of rice bran crude lecithin. The percent of nitrogen and calcium retention tended to decrease, while phosphorus retention was significantly (P < 0.01) lower with inclusion level of RBCL. The methane production (L/d, L/kgW0.75) were significantly (P < 0.05) lower in RBCL-12 followed by RBCL-8 as compared to RBCL-0 group. Serum biochemical did not show significant difference among dietary treatment groups. The cholesterol and blood urea concentration was significantly (P < 0.01) higher in RBCL-12 group as compared to control group. The rumen metabolites and microbiota showed reduction in RBCL-8 group as compare to RBCL-0 group without reach to significant (P < 0.05) level. It can be concluded, that detrimental effect of present levels (8 and 12%) of RBCL was seen in the performance of crossbred calves, which was associated with decreased fibre digestibility and fermentation in rumen. Beside this, RBCL is helpful in methane mitigation for cleaner production and can be a cheap source of energy in place of corn for ruminant. Further studies in large number of livestock are warranted to explore the potential of RBCL in the ruminant ration.