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Background & objetives: Laparoscopic procedures are usually followed by postoperative pain of variable intensity. The pain occurs due to streching of the visceral organs and peritoneum. We compared the antinociceptive effect of intraperitoneal instillation of bupivacaine with a combination of bupivacaine and dexmedetomidine in laparoscopic surgery. We assessed the quality of analgesia, time to the first request of rescue analgesia and total analgesics required in the first 24 h. Methodology: After institutional ethical committee approval a total of 162 patients were selected, out of which 81 patients were allocated into two groups using table of randomization. Group B received 0.25 % bupivacaine 50 ml with 5 ml normal saline and Group BD received 0.25 % bupivacaine 50 ml plus dexmedetomidine 1 µg/kg diluted in 5 ml of normal saline intraperitoneally. Results: We found a significant difference between mean VAS scores of the two groups in all time points (p < 0.05). There was significant difference between mean time to the first request for analgesia and the mean total dose for analgesic required (p < 0.05) in between both groups. Conclusion: We conclude that intraperitoneal instillation of dexmedetomidine 1 µg kg in combination with bupivacaine 0.25% in elective laparoscopic cholecystectomy significantly reduces the postoperative pain and analgesic requirement in postoperative period when compared to bupivacaine 0.25% alone. Abbreviations: VAS – Visual analog scale; NS - Normal saline; PACU - post‑anesthesia care unit; HR – Heart rate; Key words: Anesthetics, Local / administration & dosage; Bupivacaine / administration & dosage; Cholecystectomy, Laparoscopic / adverse effects; Dexmedetomidine, Intraperitoneal; Bupivacaine; Visual analogue scale; Pain Measurement; Pain, Postoperative / diagnosis; Pain, Postoperative / etiology; Pain, Postoperative / prevention & control Citation: Shankar S, Gupta BK, Singh MK, Pandey AR, Dwivedi V, Sachan S. Intraperitoneal bupivacaine alone or with dexmedetomidine for post-operative analgesia following laparoscopic cholecystectomy: A prospective randomized comparative study. Anaesth. pain intensive care 2022;26(3):347-351. DOI: 10.35975/apic.v26i3.1909 Received: August 09, 2021; Reviewed: November 19, 2021; Accepted: December 09, 2021

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This is to certify that the thesis entitled, "Physiological studies on moisture stress tolerance in chickpea (Cicer arietinum L.) genotypes" submitted for the degree of Master of Science in the subject of Botany (Minor subject: Biochemistry) of the Punjab Agricultural University, Ludhiana, is a bonafide research work carried out by Vaishali Sharma (L-2014-BS-271-M) under my supervision and that no part of this thesis has been submitted for any other degree. The assistance and help received during the course of investigation have been fully acknowledged.

The data were recorded on five random selected plants for 12 quantitative characters and statistical analyzed. The analysis of variance for all the twelve characters is showed the mean square due to genotypes was highly significant. The mean values of various characters like days to 50 per cent flowering were recorded maximum for genotype IC560719 and Pusa Karishma (84.00 days)with mean 69.08 days The maximum days to 75% maturity were observed in IC-560700 genotype (142.00 days) with a mean of 135.07 days. The plant height highest recorded in the genotype IC-560696 (217.60 cm) with mean of 188.14 cm. The maximum number of primary branches per plant (16.47) was recorded in the genotype NPJ-113 with mean of 10.13. The genotype NPJ-113 produced maximum number of secondary branches per plant (35.47) with mean of 19.78. The maximum length of siliqua was recorded for Kranti (7.03) with mean of 5.24cm. The maximum number of seeds per siliqua was recorded in Kranti genotype (19.13) with mean value 14.91. The maximum 1000-seed weight recorded 5.57g for Pusa Jai Kisan with mean wt. 3.96 g. Pusa Mustard-21 produced highest biological yield (191.13g) with mean 79.00g. The genotype Pusa Jagannath had maximum harvest index (30.98%) with mean value 23.87%. The oil content in mustard maximum in 42.00 % were recorded in Pusa Agrani with mean oil content was 39.16 percent. The genotype Pusa Mustard-21 showed highest seed yield per plant (47.00g) with a mean seed yield of 18.58. The higher heritability estimates in broad sense for biological yield per plant (99.6%), number of primary branches per plant (91.4%), number of secondary branches per plant (98.4) plant height (99.2%), 1000-seed weight (99.4%) and days to 50 per cent flowering (98.5). Expected genetic advance at 5% selection intensity was recorded higher for biological yield per plant (71.60) and number secondary branches per plant (10.87).