Molecular mechanisms of polysaccharides from Ziziphus jujuba Mill var. spinosa seeds regulating the bioavailability of spinosin and preventing colitis

Liu, Ying; Zhao, Xiaotong; Lin, Tingting; Wang, Qing; Zhang, Yanqing; Xie, Junbo

doi:10.1016/j.ijbiomac.2020.07.229

Cited by 15 publications

(6 citation statements)

References 58 publications

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“…polysaccharides significantly increased Firmicutes abundance and decreased Bacteroidetes abundance [40]. Hericium erinaceus polysaccharides can significantly increase microbial diversity in the gut of UC rats, with Verrucomicrobia, Firmicutes, Bacteroidetes, and Proteobacteria richness being close to levels in healthy rats [41]. In addition, Glycyrrhiza polysaccharides can regulate intestinal microbiota composition, with Enterorhabdus spp., Odoribacter spp., Ruminococcaceae_UCG_014, and Ruminiclostridium 5 as the potential targets [42].…”

Section: Nps Impact On Intestinal Microbiotamentioning

confidence: 94%

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

et al. 2022

Foods

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The incidence of inflammatory bowel disease (IBD) has increased in recent years. Considering the potential side effects of conventional drugs, safe and efficient treatment methods for IBD are required urgently. Natural polysaccharides (NPs) have attracted considerable attention as potential therapeutic agents for IBD owing to their high efficiency, low toxicity, and wide range of biological activities. Intestinal microbiota and their fermentative products, mainly short-chain fatty acids (SCFAs), are thought to mediate the effect of NPs in IBDs. This review explores the beneficial effects of NPs on IBD, with a special focus on the role of intestinal microbes. Intestinal microbiota exert alleviation effects via various mechanisms, such as increasing the intestinal immunity, anti-inflammatory activities, and intestinal barrier protection via microbiota-dependent and microbiota-independent strategies. The aim of this paper was to document evidence of NP–intestinal microbiota-associated IBD prevention, which would be helpful for guidance in the treatment and management of IBD.

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Section: Nps Impact On Intestinal Microbiotamentioning

confidence: 94%

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

et al. 2022

Foods

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“…Spinosin exists widely in Ziziphi Spinosae semen (ZSSP), which has the effects of anti-inflammation and antioxidant stress, and has a favorable curative effect on colitis, anxiety and sleep disorder ( 93 , 94 ). The water-soluble polyphenols extracted from ZSSP have significant anti-colorectal tumor activity, including inhibiting cell proliferation and promoting cell apoptosis ( 95 ).…”

Section: Molecular Targets Of Polyphenol For Cra: Preclinical Studiesmentioning

confidence: 99%

Therapeutic effects of natural polyphenols on colorectal adenomas: Focus on preclinical studies (Review)

Lin

et al. 2023

Oncol Rep

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Colorectal adenoma (CRA) is a premalignant lesion of colorectal cancer. The current treatment is surgical resection, but CRA is prone to recurrence, and there is no safe and effective drug to prevent adenoma recurrence and canceration. Recent studies have shown that natural compounds in plants have favorable antitumor effects. According to preclinical studies, natural polyphenols can regulate different signal pathways and targets to play a role in the treatment of CRA, which is closely related to its inhibition of proliferation, induction of apoptosis, inhibition of inflammation and oxidative stress, and regulation of intestinal flora. Natural polyphenols are potential candidates for CRA therapy due to their remarkable efficacy and safety. In the present review, attention was paid to the experimental research progress of natural polyphenols extracted from numerous plants in the treatment of CRA in the last 10 years. The present review provided new guidance for the study of CRA, clarified the therapeutic role of polyphenols in CRA, and evaluated for the first time, to the best of our knowledge, the therapeutic potential of natural polyphenols to treat CRA by targeting multiple genes and signal pathways and epigenetic modification. Contents 1. Introduction 2. Current treatment and management of CRA 3. Classification of polyphenols and their transformation in the intestine 4. Molecular targets of polyphenol for CRA: Preclinical studies 5. Discussion 6. Conclusion and prospects

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“…11 Histopathological analysis revealed that ZSS polysaccharides can alleviate 2,4,6-trinitrobenzene sulfonic acid (TNBS)induced colitis and reduced inflammatory cell infiltration in mice. 102 3.8. Antihypertension Effect.…”

Section: Biological Activities and Possible Healthmentioning

confidence: 99%

“…Furthermore, they can protect against IBD by enabling enhanced intestinal barrier function involving the activation of AMP-activated protein kinase (AMPK) . Histopathological analysis revealed that ZSS polysaccharides can alleviate 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis and reduced inflammatory cell infiltration in mice …”

Section: Biological Activities and Possible Health Benefitsmentioning

confidence: 99%

Wild Jujube (Ziziphus jujuba var. spinosa): A Review of Its Phytonutrients, Health Benefits, Metabolism, and Applications

Yang

Guo

et al. 2022

J. Agric. Food Chem.

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Wild jujube, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou, as a food and health supplement worldwide, has rich nutritional value. It contains nutrients such as nucleosides, amino acids, polysaccharides, and fatty oils. The fruits, seeds, and leaves of wild jujube can all be used for food, medicine, or health care purposes. Among these, the fruits play many roles, such as antioxidant, antibacterial, and anti-inflammatory functions, and can be used as a natural nutritional supplement to prevent aging. Simultaneously, the mature seed of wild jujube exhibits beneficial effects on central nervous system diseases and is often used for the treatment of insomnia and as a functional food for improving sleep quality and enhancing learning and memory. This review presents an overview of research progress relevant to the phytonutrients, biological functions, metabolism of bioactive compounds, and applications of wild jujube and aims to provide a scientific reference for the development and utilization of this plant.

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Molecular mechanisms of polysaccharides from Ziziphus jujuba Mill var. spinosa seeds regulating the bioavailability of spinosin and preventing colitis

Cited by 15 publications

References 58 publications

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Therapeutic effects of natural polyphenols on colorectal adenomas: Focus on preclinical studies (Review)

Wild Jujube (Ziziphus jujuba var. spinosa): A Review of Its Phytonutrients, Health Benefits, Metabolism, and Applications

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