Therapeutic effects of natural polyphenols on colorectal adenomas: Focus on preclinical studies (Review)

Abstract

Colorectal adenoma (CRA) is a premalignant lesion of colorectal cancer. The current treatment is surgical resection, but CRA is prone to recurrence, and there is no safe and effective drug to prevent adenoma recurrence and canceration. Recent studies have shown that natural compounds in plants have favorable antitumor effects. According to preclinical studies, natural polyphenols can regulate different signal pathways and targets to play a role in the treatment of CRA, which is closely related to its inhibition of proliferation, induction of apoptosis, inhibition of inflammation and oxidative stress, and regulation of intestinal flora. Natural polyphenols are potential candidates for CRA therapy due to their remarkable efficacy and safety. In the present review, attention was paid to the experimental research progress of natural polyphenols extracted from numerous plants in the treatment of CRA in the last 10 years. The present review provided new guidance for the study of CRA, clarified the therapeutic role of polyphenols in CRA, and evaluated for the first time, to the best of our knowledge, the therapeutic potential of natural polyphenols to treat CRA by targeting multiple genes and signal pathways and epigenetic modification. Contents 1. Introduction 2. Current treatment and management of CRA 3. Classification of polyphenols and their transformation in the intestine 4. Molecular targets of polyphenol for CRA: Preclinical studies 5. Discussion 6. Conclusion and prospects

Rowanberry—A Source of Bioactive Compounds and Their Biopharmaceutical Properties

“…Cancer cells arise due to genetic mutations in suppressor genes or oncogenes [ 108 ]. Polyphenols, by annihilating free radicals, protect the genetic material of the cell from carcinogenesis or other damage [ 101 ].…”

Recent Advances in Nanotechnology-Based Targeted Delivery Systems of Active Constituents in Natural Medicines for Cancer Treatment

“…The results showed the evidence that CUR-loaded polymeric nanocapsules inhibit tumor growth (p < 0.00001) and decrease tumor weight (p = 0.0006) in rodents was established. Natural polyphenols, such as apigenin and kaempferol, had therapeutic effects on colorectal adenoma by regulating different signaling pathways and targets [214]. These natural products are all effective and promis-ing candidates for the treatment of cancer and are expected to be introduced into medical practice in the future.…”

Natural polyphenols: A protective approach to reduce colorectal cancer

“…Similarly, it has been shown that other significant polyphenols, such resveratrol and curcumin, are active in treating a variety of illnesses. Polyphenols have a variety of physiological functions, including antibacterial, antioxidant, anti-inflammatory, antimalarial, antiviral, antitumor, and immunomodulatory properties [13] , 14 . They may be able to also lessen the oxidative damage of enzymes and DNA in cells and tissues.…”

“…Polyphenols are thought to be a significant source of natural medications for management of many diseases because of their exceptional efficacy and safety [ [15] , [16] , [17] ], as evidenced by the various studies that have demonstrated their impact of inhibition on CRC [ 6 , 13 , 14 ]. Nevertheless, there are a number of restrictions on the therapeutic uses of phenolic chemicals.…”